摆线轮齿形的组合修正方式及其优化设计

针对齿形已经确定的摆线轮,在修正方式及修正量未知的情况下,利用改进的复合形法对摆线轮齿形修正方式及修正量进行了优化分析．同时,采用工艺过程简单的“等距＋ 移距” 修正方式代替工艺过程较复杂的转角修正方式,使用该方法计算等距和移距修正量速度快,与传统的计算方法相比较,工作效率明显提高．计算结果表明：在摆线轮齿形的各种修正方式中,“正等距＋ 负移距”修正方式是较理想的摆线轮齿形修正方式．这种修正方式具有理想齿形,加工工艺简单,在设计与制造中有一定的推广使用价值     

加劲压力钢管结构优化设计

提出了改进加劲压力钢管设计的新思想,建立了加劲压力钢管结构优化设计的数学模型,介绍了约束非线性混合离散变量最优化方法的基本原理及其工程应用,研制了加劲压力钢管结构优化设计通用程序（ＯＳＤＰＲ）。结合工程实例,对加劲压力钢管进行优化设计,经济效益显著。     

6063铝合金挤压型材质量影响因素及解决方法

挤压铸锭的质量对铝型材的质量有着举足轻重的影响，高质量的挤压铸锭是获得高质量铝型材的基础。本文分别从铝型材的化学元素成分控制、熔体质量、铸造的工艺参数、铸锭的均匀化处理等方面探讨了提高6063铝合金挤压铸锭质量的技术途径。     

用~(14)N(d,α_1)~(12)C核反应研究注入氮在纯铁和GCr15钢中的深度分布

本文描述了利用~(14)N(d,a_1)~(12)C核反应测量固体样品表面层内氮原子含量及深度分布的方法。在Si_3N_4标准样品中,所得到的表面处的深度分辨为48nm。利用该分析手段,研究了在不同注入温度条件下,氮离子注入纯铁和GCr15钢的保留量及深度分布的变化情况。     

计及数据不平衡的RUSBoost-LightGBM 短期负荷预测方法

随着人工智能技术的发展,负荷预测的准确度显著提高,但仍有一些负荷曲线预测精度较低。造成这种现象的原因 在于训练集中这类负荷曲线属于少数类,导致数据不平衡,模型无法充分学习,从而影响了预测的精度。为解决电力负荷数 据不平衡问题导致的预测精度降低的问题,提出了一种先分类后预测的解决方法。通过改进的K-Mediods 方法把具有高相 似性的历史负荷曲线进行聚类,并构造分类标签与电力负荷的特征集;然后根据预测时间的特征进行分类,通过RUSBoost 算 法很好的优化了分类过程中数据不平衡问题;最后在每类中使用LightGBM算法进行负荷预测。在公开数据集上的实验表 明,所提出方法对少数类负荷的预测效果显著,其平均绝对百分比误差(MAPE) 为2.95%,均方根误差(RMSE) 为 175.71 MW;对于常规负荷的预测,MAPE为3 .52%,RMSE为195.84 MW,相对其他方法也具有较好的预测效果。     

电动缸式钢包长水口机械手的技术改造

介绍了宝钢5号连铸机钢包长水口机械手的设备构成及技术性能,阐述设备长时间运行所存在的问题,针对问题提出了设备改进的措施。     

Research methods for profile analysis: Introduction to the special issue.

The five articles that make up the bulk of this special issue collectively illustrate new methods for examining the utility of sub-test and scale-level profile analysis. By necessity they are preliminary, but they illustrate methods that may indeed prove useful and may help resolve this divide between research and practice. This special issue grew out of a symposium conceived and organized by Cecil Reynolds at the American Psychological Association in 1998. The articles and one of the commentaries in this special issue are extensions of that symposium. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

基于“模拟电路”课程开展五环导学法的研究

模拟电路课程在理论性、实践性和工程性等方面的表现均十分突出,是高校学员学习非常吃力的一门课程,如何提高课堂效率,充分利用课前、课中、课后的时间提高学员的理论基础和综合素质,是目前高校模拟电路教学工作中亟待解决的问题。本文以模拟电路课程为依托,深入研究课程内容的特点,构思在课程中开展五环导学法的方法,设计教学活动,并给出实施的策略和方法。     

Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I2 Receptor Ligand B06

The impact of neurodegenerative diseases (ND) is becoming unbearable for humankind due to their vast prevalence and the lack of efficacious treatments. In this scenario, we focused on imidazoline I₂ receptors (I₂-IR) that are widely distributed in the brain and are altered in patients with brain disorders. We took the challenge of modulating I₂-IR by developing structurally new molecules, in particular, a family of bicyclic α-iminophosphonates, endowed with high affinity and selectivity to these receptors. Treatment of two murine models, one for age-related cognitive decline and the other for Alzheimer’s disease (AD), with representative compound B06 ameliorated their cognitive impairment and improved their behavioural condition. Furthermore, B06 revealed beneficial in vitro ADME-Tox properties. The pharmacokinetics (PK) and metabolic profile are reported to de-risk B06 for progressing in the preclinical development. To further characterize the pharmacological properties of B06, we assessed its neuroprotective properties and beneficial effect in an in vitro model of Parkinson’s disease (PD). B06 rescued the human dopaminergic cell line SH-SY5Y from death after treatment with 6-hydroxydopamine (6-OHDA) and showed a crucial anti-inflammatory effect in a cellular model of neuroinflammation. This research reveals B06 as a putative candidate for advancing in the difficult path of drug discovery and supports the modulation of I₂-IR as a fresh approach for the therapy of ND.     

SURFACE ROUGHNESS OF SPUTTERED SILICON. II. MODEL VERIFICATION

Experimental verification of the mathematical surface roughness model for sputtered silicon was performed. The beam shape and its significant level of intensity were determined first by measuring the topography of craters sputtered by focused ion beam (FIB). Then the beam function was generated for various combinations of beam parameters. The material function was developed both by theoretical and experimental analysis. These two functions were then used in the model to calculate the theoretical surface roughness. Microsurface analysis was formed by FIB sputtering of a (100) silicon wafer. The surface roughness at the bottom of the sputtered features was then measured using an atomic force microscope. The theoretical surface roughness was found to be within ±1 and ±5 nm of the measured surface roughness with the measurement uncertainty (standard deviation) of about ±0.36 and ±0.85 nm for R_a and R_t, respectively.