全文获取类型
收费全文 | 14334篇 |
免费 | 908篇 |
国内免费 | 310篇 |
专业分类
电工技术 | 464篇 |
技术理论 | 5篇 |
综合类 | 1392篇 |
化学工业 | 3002篇 |
金属工艺 | 291篇 |
机械仪表 | 573篇 |
建筑科学 | 1525篇 |
矿业工程 | 146篇 |
能源动力 | 354篇 |
轻工业 | 1071篇 |
水利工程 | 158篇 |
石油天然气 | 180篇 |
武器工业 | 125篇 |
无线电 | 1001篇 |
一般工业技术 | 2858篇 |
冶金工业 | 237篇 |
原子能技术 | 158篇 |
自动化技术 | 2012篇 |
出版年
2024年 | 76篇 |
2023年 | 272篇 |
2022年 | 624篇 |
2021年 | 627篇 |
2020年 | 386篇 |
2019年 | 364篇 |
2018年 | 327篇 |
2017年 | 408篇 |
2016年 | 457篇 |
2015年 | 477篇 |
2014年 | 919篇 |
2013年 | 1157篇 |
2012年 | 1167篇 |
2011年 | 828篇 |
2010年 | 724篇 |
2009年 | 825篇 |
2008年 | 697篇 |
2007年 | 584篇 |
2006年 | 490篇 |
2005年 | 423篇 |
2004年 | 331篇 |
2003年 | 280篇 |
2002年 | 242篇 |
2001年 | 200篇 |
2000年 | 149篇 |
1999年 | 136篇 |
1998年 | 109篇 |
1997年 | 60篇 |
1996年 | 1070篇 |
1995年 | 487篇 |
1994年 | 344篇 |
1993年 | 24篇 |
1992年 | 25篇 |
1991年 | 25篇 |
1990年 | 18篇 |
1989年 | 17篇 |
1988年 | 23篇 |
1987年 | 15篇 |
1986年 | 15篇 |
1985年 | 32篇 |
1984年 | 38篇 |
1983年 | 17篇 |
1982年 | 15篇 |
1981年 | 12篇 |
1980年 | 9篇 |
1979年 | 2篇 |
1978年 | 9篇 |
1977年 | 6篇 |
1976年 | 5篇 |
1973年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Chun-Yuan Cheng Lassina Barro Shang-Ting Tsai Tai-Wei Feng Xiao-Yu Wu Che-Wei Chao Ruei-Siang Yu Ting-Yu Chin Ming Fa Hsieh 《International journal of molecular sciences》2021,22(6)
Microglia-mediated neuroinflammation is recognized to mainly contribute to the progression of neurodegenerative diseases. Epigallocatechin-3-gallate (EGCG), known as a natural antioxidant in green tea, can inhibit microglia-mediated inflammation and protect neurons but has disadvantages such as high instability and low bioavailability. We developed an EGCG liposomal formulation to improve its bioavailability and evaluated the neuroprotective activity in in vitro and in vivo neuroinflammation models. EGCG-loaded liposomes have been prepared from phosphatidylcholine (PC) or phosphatidylserine (PS) coated with or without vitamin E (VE) by hydration and membrane extrusion method. The anti-inflammatory effect has been evaluated against lipopolysaccharide (LPS)-induced BV-2 microglial cells activation and the inflammation in the substantia nigra of Sprague Dawley rats. In the cellular inflammation model, murine BV-2 microglial cells changed their morphology from normal spheroid to activated spindle shape after 24 h of induction of LPS. In the in vitro free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, EGCG scavenged 80% of DPPH within 3 min. EGCG-loaded liposomes could be phagocytized by BV-2 cells after 1 h of cell culture from cell uptake experiments. EGCG-loaded liposomes improved the production of BV-2 microglia-derived nitric oxide and TNF-α following LPS. In the in vivo Parkinsonian syndrome rat model, simultaneous intra-nigral injection of EGCG-loaded liposomes attenuated LPS-induced pro-inflammatory cytokines and restored motor impairment. We demonstrated that EGCG-loaded liposomes exert a neuroprotective effect by modulating microglia activation. EGCG extracted from green tea and loaded liposomes could be a valuable candidate for disease-modifying therapy for Parkinson’s disease (PD). 相似文献
102.
Kvin Nay William J. Smiles Jacqueline Kaiser Luke M. McAloon Kim Loh Sandra Galic Jonathan S. Oakhill Andrew L. Gundlach John W. Scott 《International journal of molecular sciences》2021,22(8)
As life expectancy has increased, particularly in developed countries, due to medical advances and increased prosperity, age-related neurological diseases and mental health disorders have become more prevalent health issues, reducing the well-being and quality of life of sufferers and their families. In recent decades, due to reduced work-related levels of physical activity, and key research insights, prescribing adequate exercise has become an innovative strategy to prevent or delay the onset of these pathologies and has been demonstrated to have therapeutic benefits when used as a sole or combination treatment. Recent evidence suggests that the beneficial effects of exercise on the brain are related to several underlying mechanisms related to muscle–brain, liver–brain and gut–brain crosstalk. Therefore, this review aims to summarize the most relevant current knowledge of the impact of exercise on mood disorders and neurodegenerative diseases, and to highlight the established and potential underlying mechanisms involved in exercise–brain communication and their benefits for physiology and brain function. 相似文献
103.
Lorena Cuenca-Bermejo Elisa Pizzichini Valeria C. Gonalves María Guilln-Díaz Elena Aguilar-Moino Consuelo Snchez-Rodrigo Ana-María Gonzlez-Cuello Emiliano Fernndez-Villalba María Trinidad Herrero 《International journal of molecular sciences》2021,22(9)
The diurnal rodent Octodon degus (O. degus) is considered an attractive natural model for Alzheimer’s disease and other human age-related features. However, it has not been explored so far if the O. degus could be used as a model to study Parkinson’s disease. To test this idea, 10 adult male O. degus were divided into control group and MPTP-intoxicated animals. Motor condition and cognition were examined. Dopaminergic degeneration was studied in the ventral mesencephalon and in the striatum. Neuroinflammation was also evaluated in the ventral mesencephalon, in the striatum and in the dorsal hippocampus. MPTP animals showed significant alterations in motor activity and in visuospatial memory. Postmortem analysis revealed a significant decrease in the number of dopaminergic neurons in the ventral mesencephalon of MPTP animals, although no differences were found in their striatal terminals. We observed a significant increase in neuroinflammatory responses in the mesencephalon, in the striatum and in the hippocampus of MPTP-intoxicated animals. Additionally, changes in the subcellular expression of the calcium-binding protein S100β were found in the astrocytes in the nigrostriatal pathway. These findings prove for the first time that O. degus are sensitive to MPTP intoxication and, therefore, is a suitable model for experimental Parkinsonism in the context of aging. 相似文献
104.
Tsuyoshi Nakai Kiyofumi Yamada Hiroyuki Mizoguchi 《International journal of molecular sciences》2021,22(11)
Alzheimer’s disease (AD) is an age-related and progressive neurodegenerative disorder. It is widely accepted that AD is mainly caused by the accumulation of extracellular amyloid β (Aβ) and intracellular neurofibrillary tau tangles. Aβ begins to accumulate years before the onset of cognitive impairment, suggesting that the benefit of currently available interventions would be greater if they were initiated in the early phases of AD. To understand the mechanisms of AD pathogenesis, various transgenic mouse models with an accelerated accumulation of Aβ and tau tangles have been developed. However, none of these models exhibit all pathologies present in human AD. To overcome these undesirable phenotypes, APP knock-in mice, which were presented with touchscreen-based tasks, were developed to better evaluate the efficacy of candidate therapeutics in mouse models of early-stage AD. This review assesses several AD mouse models from the aspect of biomarkers and cognitive impairment and discusses their potential as tools to provide novel AD therapeutic approaches. 相似文献
105.
Mootaz M. Salman Zaid Al-Obaidi Philip Kitchen Andrea Loreto Roslyn M. Bill Richard Wade-Martins 《International journal of molecular sciences》2021,22(9)
Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. In this review, we provide an introduction to CADD and examine the progress in applying CADD and other molecular docking studies to NDs. We provide an updated overview of potential therapeutic targets for various NDs and discuss some of the advantages and disadvantages of these tools. 相似文献
106.
Ewa ya Katarzyna Dziendzikowska Dariusz Kamola Jacek Wilczak Rafa Sapierzyski Joanna Harasym Joanna Gromadzka-Ostrowska 《International journal of molecular sciences》2021,22(9)
Background: The incidence of Crohn’s disease (CD) is increasing worldwide, and it has currently become a serious public health issue in society. The treatment of CD continues throughout a patient’s lifetime, and therefore, it is necessary to develop new, effective treatment methods, including dietotherapy. The present study aimed to determine the effects of consumption of oat beta-glucans with different molar mass on colon inflammation (colitis) in the early stages of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced CD in an animal model. Methods: Sprague–Dawley rats (control and TNBS-induced CD) were divided into three dietary groups and fed for 3 days (reflecting acute inflammation) or 7 days (reflecting remission) with a feed containing 1% low (βGl) or high (βGh) molar mass oat beta-glucan or a feed without this polysaccharide. The level of colon inflammatory markers and the expression of cytokines and their receptor genes were measured by ELISA and RT-PCR methods, respectively. Results: Acute inflammation or remission (3 or 7 days after TNBS administration, respectively) stages of experimentally induced CD were characterized by an increase in the level of inflammatory markers (IL-1, IL-6, IL-10, IL-12, TNF-α, CRP, MPO, COX, and PGE2) and the disruption of some cytokine signaling pathways as well as macro- and microscopic changes of colon tissue. The consumption of oat beta-glucans reduced the level of inflammatory markers and recovered the signaling pathways and histological changes, with stronger effects of βGl after 7 days of colitis. Conclusions: Dietary oat beta-glucans can reduce colitis at the molecular and organ level and accelerate CD remission. 相似文献
107.
在含B4C中性盐浴渗硼的高温反应研究的基础上,对该盐浴存在的工艺问题进行了分析研究。指出了渗硼能力均匀性,工件表面腐蚀斑与玻璃体的关系,分析了老化盐致使工件清洗困难的成因。 相似文献
108.
Effect of cold spray deposition of a titanium coating on fatigue behavior of a titanium alloy 总被引:1,自引:0,他引:1
The deposition of titanium on a titanium alloy substrate is being examined for potential use as a surface treatment for medical
prostheses. A Ti6Al4V alloy was coated with pure titanium by cold gas dynamic spraying. Coatings were deposited onto samples
with two different surface preparation methods (as-received and grit-blasted). The fatigue life of the as-received and grit-blasted
materials, both before and after coating, was measured with a rotating-bend fatigue rig. A 15% reduction in fatigue endurance
limit was observed after application of the coating to the as-received substrate, but no significant reduction was observed
on its application to the grit-blasted substrate. The reduction in fatigue endurance limit has been related to the substrate-coating
interface properties, the elastic modulus, and the residual stress states.
This article was originally published inBuilding on 100 Years of Success, Proceedings of the 2006 International Thermal Spray Conference, (Seattle, WA), May 15–18, 2006, B.R. Marple, M.M. Hyland, Y.-Ch. Lau, R.S. Lima, and J. Voyer, Ed., ASM International, Materials
Park, 2006. 相似文献
109.
四异丁氧基镍酞菁的合成及其溶剂效应 总被引:2,自引:0,他引:2
4 异丁氧基邻苯二腈与氯化镍在强有机碱 1 ,8 二氮杂双环 (5 ,4,0 )十一碳烯 7催化下反应 ,合成了四异丁氧基镍酞菁 ,产物经FT -IR、元素分析、UV -Vis吸收光谱和1 H NMR表征了结构 ;并研究了其溶剂效应 ,结果表明 :最大吸收峰波数ν与函数 f(n ,ε)存在一定的线性关系 ,线性相关系数为 0 940 2 ,而Bayliss函数项 (n2 - 1 ) /(2n2 +1 )决定了最大吸收波长 (λmax)的位移变化 ;化合物的λmax在不同溶剂中随聚集程度增加 ,发生一定程度的蓝移 相似文献
110.