基于冲突延迟策略的约束群体自组装模型

对二维网格空间上的群体自组装问题进行了较为深入的研究,给出了确保组装结构侧面连通性的充分必要条件,并进行了严格证明,以此为基础提出了基于最大相邻侧面封闭及冲突等待策略的群体自组装模型,该模型在并行的条件下,可以组装任意二维空间上的侧面连通结构,通过仿真和实验对所提出的模型进行了验证与分析。     

特高压GIS现场安装用全封闭移动式厂房研制与应用

特高压GIS现场安装用全封闭移动式厂房是一种用于户外GIS设备安装的新型工装,能够在工程现场营造一种全封闭的安装环境,克服外部环境对GIS安装的影响,保证GIS安装质量,提高安装效率,并为安装人员提供良好的工作环境。介绍了特高压GIS现场安装用全封闭移动式厂房的研制背景、基本结构形式与应用方式、工程应用情况及社会经济效益等内容。特高压GIS现场安装用全封闭移动式厂房在皖电东送工程、浙北—福州特高压交流输变电工程中进行了试用及全线推广应用,取得了非常好的效果,目前已确定在后续全部特高压交流工程中普遍应用。     

A novel design for stable self-assembly cubosome precursor-microparticles enhancing dissolution of insoluble drugs

Cubosomes have been presented to enhance dissolution of insoluble drugs, but their applications are limited by the practical hurdles associated with both preparation and storage instability, resulting in drug delivery failure. In the present study, an innovative cubosome precursor-microparticles (CPMs) spray dried from an aqua-free precursor solution was developed to improve cubosome stability during both preparation and storage as well as to enhance the dissolution of insoluble drugs. These CPMs spontaneously self-assembled in situ forming homogeneous cubosome dispersion by hydration and disintegration after exposure to the aqueous medium. The stable cubosome dispersion was obtained from self-assembly (SA) of CPMs after administration instead of fragmentation of bulk cubic phase gel into cubosomes, which settled the preparation instability due to avoidance of high energy fragmentation (e.g. ultrasonic effect, high speed shear and high pressure homogenization). Also, the subsequent storage instability issue can be excluded as the CPMs were stored in a solid stable form. The CPMs disintegration and cubosome SA were demonstrated by the notable morphology variation and the distinct microparticle size decrease from CPMs (10–20?μm) to SA-cubosomes (150–200?nm). The cumulative release of docetaxel (DTX, model insoluble drug) incorporated in CPMs increased to 96.4% within 120?minutes compared with only 75.2% for blank CPMs and DTX physical mixture, demonstrating that CPMs significantly enhanced the dissolution extent of insoluble drug. The SA-cubosomes possessed quite high drug entrapment efficiency (>95%) and an integrated drug dissolution content, which significantly increased the drug utilization rate.     

Self-Assembled Glucose and Thermo Dual-Responsive Micelles of an Amphiphilic Graft Copolymer

Amphiphilic copolymers P(PBA)-g-P(PEG) containing poly(phenylboronic acid) (PPBA) and poly(ethylene glycol) (PEG) side chains were synthesized by copolymerization of 4-vinylphenylboronic acid (PBA) and poly(ethylene glycol) methyl ether methacrylate. The surface tension results showed that the critical micelle concentration (CMC) of P(PBA)-g-P(PEG) was 0.09 g/L. TEM revealed that these copolymers self-assembled into regular sphere micelles above CMC. The photon correlation spectroscopy suggested that they had unique performance of thermo-induced self-assembly. Above critical micelle temperature, they self-assembled into monodisperse micelles with thermosensitivity. Hydrodynamic diameters of these micelles increased dramatically in the presence of glucose. The glucose-regulated drug release behavior was observed through UV-vis spectroscopy.     

自组装技术在水处理中的应用

介绍了自组装单层及其制备方法，论述了有机硅烷系自组装单层材料可吸附水中金属离子和有机污染物，使水质得到净化，并可用于处理果汁、酒中的有害杂质。采用制备的NH2-SAMs／SiO2处理水中残留的杀虫剂simazine（4mg／L）作为探针反应，去除率达到了76．5％。进一步利用固定在基质上的自组装单层诱导生长TiO2和FeOOH纳米膜作为新型光催化水处理材料，讨论了其吸附、光催化降解水中污染物的方法和应用前景。     

Dynamic self-assembly in living systems as computation

Biochemical reactions taking place in living systems that map different inputs to specific outputs are intuitively recognized as performing information processing. Conventional wisdom distinguishes such proteins, whose primary function is to transfer and process information, from proteins that perform the vast majority of the construction, maintenance, and actuation tasks of the cell (assembling and disassembling macromolecular structures, producing movement, and synthesizing and degrading molecules). In this paper, we examine the computing capabilities of biological processes in the context of the formal model of computing known as the random access machine (RAM) [Dewdney AK (1993) The New Turing Omnibus. Computer Science Press, New York], which is equivalent to a Turing machine [Minsky ML (1967) Computation: Finite and Infinite Machines. Prentice-Hall, Englewood Cliffs, NJ]. When viewed from the RAM perspective, we observe that many of these dynamic self-assembly processes – synthesis, degradation, assembly, movement – do carry out computational operations. We also show that the same computing model is applicable at other hierarchical levels of biological systems (e.g., cellular or organism networks as well as molecular networks). We present stochastic simulations of idealized protein networks designed explicitly to carry out a numeric calculation. We explore the reliability of such computations and discuss error-correction strategies (algorithms) employed by living systems. Finally, we discuss some real examples of dynamic self-assembly processes that occur in living systems, and describe the RAM computer programs they implement. Thus, by viewing the processes of living systems from the RAM perspective, a far greater fraction of these processes can be understood as computing than has been previously recognized.     

Gold Nanoparticulate Thin Films Fabricated by the Electrostatic Self—Assembly Process

Gold colloids were prepared by citrate-induced reduction of hydrogen tetrachlorourate, and gold nanoparticles were electrostatically self-assembled with poly (diallyldimethylammonium chloride) into multilayer thin films on silicon and quartz substrates. The particulate thin films were characterized by UV-vis spectroscopy, surface enhanced Raman scattering, atomic force microscopy and resistivity measurements. Due to the interparticle coupling between individual gold particles, an obvious collective particle plasmon resonance was observed on UV-vis spectra, and the particulate thin films exhibited a strong SERS effect. For multilayer thin films with a high particle coverage on substrates, resistivity of the order of 10⁻⁴Ω·cm was yielded. Yu Hai-hu This research was financially supported by China Scholarship Council and the Natural Science Foundation of Hubei Province (Project 2000J002)     

对称性分子间氢键诱导液晶

本文以４－［（４－烷氧基苯甲酰氧基）－４’－苯乙烯基］－吡啶（７ＳＺ和１０ＳＺ）为质子受体．以脂肪族二元羧酸（ｍＤＡ）为质子给体，合成了对称性的氢键复和物。其液晶行为经ＤＳＣ和偏光显微镜研究，结果表明复合物的液晶范围较相应的质子受体的液晶范围宽．