实测卫星频谱占用状态拟合与预测方法

由于在不同时间、不同空间卫星接收数据底噪是动态起伏的,传统建模固定门限的方法存在缺陷。本文在时间维度上对卫星频谱感知数据的频谱占用模型进行分析,利用自适应阈值法确定噪声门限,对卫星频谱数据进行预处理,得到卫星频谱占用长度序列。为对卫星频谱的态势进行有效的统计分析,利用泊松分布和指数分布方法对频谱占用时间长度序列的概率密度曲线进行拟合,得到了适用于卫星频谱占用时间序列的概率分布模型。基于所得的卫星频谱占用状态模型,通过两状态马尔可夫链计算出卫星信道某一频点的状态转移矩阵,从而预测出信道占用和空闲的概率。利用卫星频谱感知数据构建的数据集进行反向传播(BP)神经网络训练,预测某一频点的占用长度。通过计算BP神经网络与传统的长短期记忆(LSTM)神经网络预测法的均方根误差(RMSE),得到LSTM神经网络的RMSE为2.208 1,BP神经网络的RMSE为0.172 8。评估结果表明,BP神经网络准确度高。     

低速风洞应变天平通道极性判断方法

为提高低速风洞应变天平工作效率,提出一种直接单分量加载判断天平通道极性的方法。通过对单分量 加载结果进行估计,筛选不同通道极性组合时的天平计算结果。实验结果表明：该方法能快速、有效地判断天平通 道极性,并且不依靠经验,支持自动化程序化运行;对加载精度要求较低,容易满足实用要求。     

Hyperinsulinemic Hypoglycemia Associated with a CaV1.2 Variant with Mixed Gain- and Loss-of-Function Effects

The voltage-dependent L-type calcium channel isoform Ca_V1.2 is critically involved in many physiological processes, e.g., in cardiac action potential formation, electromechanical coupling and regulation of insulin secretion by beta cells. Gain-of-function mutations in the calcium voltage-gated channel subunit alpha 1 C (CACNA1C) gene, encoding the Ca_V1.2 α₁-subunit, cause Timothy syndrome (TS), a multisystemic disorder that includes autism spectrum disorders and long QT (LQT) syndrome. Strikingly, TS patients frequently suffer from hypoglycemia of yet unproven origin. Using next-generation sequencing, we identified a novel heterozygous CACNA1C mutation in a patient with congenital hyperinsulinism (CHI) and associated hypoglycemic episodes. We characterized the electrophysiological phenotype of the mutated channel using voltage-clamp recordings and in silico action potential modeling experiments. The identified Ca_V1.2^L566P mutation causes a mixed electrophysiological phenotype of gain- and loss-of-function effects. In silico action potential modeling supports that this mixed electrophysiological phenotype leads to a tissue-specific impact on beta cells compared to cardiomyocytes. Thus, CACNA1C variants may be associated with non-syndromic hyperinsulinemic hypoglycemia without long-QT syndrome, explained by very specific electrophysiological properties of the mutated channel. We discuss different biochemical characteristics and clinical impacts of hypoglycemia in the context of CACNA1C variants and show that these may be associated with significant morbidity for Timothy Syndrome patients. Our findings underline that the potential of hypoglycemia warrants careful attention in patients with CACNA1C variants, and such variants should be included in the differential diagnosis of non-syndromic congenital hyperinsulinism.     

基于低温直接键合的血细胞计数芯片结构制备

研究了一种新颖的微流管道血细胞计数器的结构及其工作原理,采用流体动力学对其液体分层流动特性进行了仿真分析,结合图形制备和低温直接键合工艺制作了硅基微流体管道血细胞计数器结构,并采用红外透射方法对微流体管道结构进行了检测.对封闭管道的流通性及结构的键合强度也进行了测量.研究分析表明,采用上述工艺制备的微流体芯片结构与电子器件兼容性好,具有良好的化学惰性和热稳定性,而且管道结构规则,精度高,键合界面层薄,具有较好的应用前景.     

Mechanical Load and Piezo1 Channel Regulated Myosin II Activity in Mouse Lenses

The cytoarchitecture and tensile characteristics of ocular lenses play a crucial role in maintaining their transparency and deformability, respectively, which are properties required for the light focusing function of ocular lens. Calcium-dependent myosin-II-regulated contractile characteristics and mechanosensitive ion channel activities are presumed to influence lens shape change and clarity. Here, we investigated the effects of load-induced force and the activity of Piezo channels on mouse lens myosin II activity. Expression of the Piezo1 channel was evident in the mouse lens based on immunoblot and immufluorescence analyses and with the use of a Piezo1^-tdT transgenic mouse model. Under ex vivo conditions, change in lens shape induced by the load decreased myosin light chain (MLC) phosphorylation. While the activation of Piezo1 by Yoda1 for one hour led to an increase in the levels of phosphorylated MLC, Yoda1 treatment for an extended period led to opacification in association with increased calpain activity and degradation of membrane proteins in ex vivo mouse lenses. In contrast, inhibition of Piezo1 by GsMTx4 decreased MLC phosphorylation but did not affect the lens tensile properties. This exploratory study reveals a role for the mechanical load and Piezo1 channel activity in the regulation of myosin II activity in lens, which could be relevant to lens shape change during accommodation.     

挤出机双流道筒体的设计及换热能力的计算与分析

介绍了设计双流道筒体的必要性,通过建立物理、数学模型详细论述了双流道筒体的设计原理及换热计算过程,并通过试验对比分析验证了模型的可靠性,同时对单、双流道筒体的换热能力进行对比分析,得出了可靠的结论.     

水与城市——以杭州城西水街为例,探讨商住区的河道处理

该文从空间入手,以杭州城西水街为例,研究了水与城市有机结合的方法和必要性,阐明其中所蕴含的文化沉积和历史底蕴是值得我们去感悟的。     

A multi-port D-R mutator using CCIIs with current followers

A multi-port D-R mutator with new current conveyors (CFCCIIs) as the four-port active element is proposed. Each CFCCII consists of a current follower added to a second-generation current conveyor (CCII). This proposed circuit is a simple configuration using CCIIs, CFCCIIs and grounded capacitances and is applied to higher order high-pass filters. This configuration can realize a superior transmission characteristic, inheriting the characteristic of the conventional LC filter. Since all the passive elements are grounded, the influence of parasitic elements of current conveyors can be reduced with this circuit configuration. As a result, this circuit is considered a suitable configuration for monolithic integration. Results obtained from the SPICE simulations show the realized filters have excellent performance and the circuit is effective.     

多用户MIMO双向中继信道鲁棒预编码

在多用户MIMO双向中继系统中,若使用非理想信道模型,中继处仅能获得部分下行信道状态信息,这样将导致系统性能大幅度下降。由此提出基于最小信干噪比最大化的鲁棒预编码方案。仿真表明,该方案不仅可以使最差信干噪比最大化,也有效地改善了系统的比特误码率性能。     

蛇形防护布线设计

高速电路中蛇形线可作为传统防护布线的替代方案,但其提出过程未曾考虑如何进行合理的设计。文中基于蛇形防护布线的外形特征影响耦合参数的原理,通过全波求解器建立蛇形防护布线模型,分析了其端接策略以及特征变化对应的远端串扰变化规律,得出了蛇形防护布线的合理设计方法。结果表明,短路策略作为最佳策略,且在信号边沿变化较快的情况下,应采用线宽小、高度高和长度短的蛇形线作为防护布线。