蒸汽喷射泵超音速流体三维模拟研究

利用大型流体力学软件FLUENT，对不同结构尺寸和边界条件的蒸汽喷射泵喷嘴内超音速流场进行了3D模拟。探讨了流场内压力和速度的相互作用及其分布规律；讨论了热力学参数和几何参数对流场特性的影响规律；并分析了喷嘴内影响喷射器性能的激波产生的因素。基本上与Dayton和石井博的研究结果一致。     

激光诱导冲击成形的研究进展

激光冲击成形是一种利用高能短脉冲激光诱导的高幅冲击波的力效应使板料产生塑性变形的新技术。本文介绍了激光冲击成形的原理,系统阐述了成形工艺参数对成形质量的影响。在总结激光冲击成形研究现状的基础上,指出激光动高压加载驱动成形方法是激光冲击成形的发展方向。最后提出动高压加载驱动成形可以在微体积成形方面进行应用拓宽。     

金属板料激光冲孔成形技术研究

为了验证激光冲击波冲孔工艺的可行性,采用Nd玻璃高功率脉冲激光器在0.4mm厚锻铝合金板料上进行冲孔试验.推导出激光冲孔工艺中板料脱离时所需理论最小板料运动速度,分析了激光冲击波冲孔技术的机理及其特点.结果表明,激光冲击波冲孔后,孔周围材料未发生扭曲变形、孔口光滑.激光冲孔技术为孔成形工艺提供了全新的加工方法.     

平顶光束激光冲击2024铝合金诱导残余应力场的模拟与实验

对平顶光束激光冲击2024铝合金诱导的残余应力情况进行了有限元模拟与实验研究。改进了平顶光束诱导冲击波的压力分布模型,并将该模型用于残余应力场的有限元模拟。在实验室环境下获得了适合用于激光冲击的高质量平顶光束,并使用该光束进行激光冲击2024铝合金的实验,实验结果和模拟结果基本一致。研究发现平顶光束冲击2024铝合金有如下特点:存在一个阈值,当激光冲击波压力小于该阈值时,影响区内残余应力场近似均匀分布;当冲击波压力大于该阈值时会引起"残余应力洞",但该"残余应力洞"内部近似均匀分布。在深度方向上,塑性影响深度和最大残余应力深度随激光冲击波压力的增加而增加。     

基于PCB传感器的小型冲击波存储测试系统

针对冲击波超压测试存在的问题,设计了一套小型冲击波存储测试系统。系统选取了美国PCB公司的压电传感器,并针对此传感器设计了相应的电荷放大器,放大器和滤波器。系统以FPGA为核心驱动外围AD和FIFO完成数据采集。对关键时序采用Modelsim软件进行了仿真。使用该系统对某爆炸20m处的冲击波超压信号进行了检测,并给出了波形。     

约束条件对薄板激光冲击表面完整性的影响

为了研究约束条件对薄板激光冲击表面完整性的影响,对厚度为1 mm的304不锈钢薄板进行了激光冲击强化处理,分析了两端夹持和底部全约束条件下,板材表面形貌、显微硬度和微观组织的差异,并通过数值模拟和实验研究了不同厚度板材的表面残余应力分布和约束条件的影响机理.结果表明,底部全约束试样表面凹坑深度约14μm,远小于两端夹持...     

Heat Shock Alters the Proteomic Profile of Equine Mesenchymal Stem Cells

The aim of this research was to determine the impact of heat stress on cell differentiation in an equine mesenchymal stem cell model (EMSC) through the application of heat stress to primary EMSCs as they progressed through the cell specialization process. A proteomic analysis was performed using mass spectrometry to compare relative protein abundances among the proteomes of three cell types: progenitor EMSCs and differentiated osteoblasts and adipocytes, maintained at 37 °C and 42 °C during the process of cell differentiation. A cell-type and temperature-specific response to heat stress was observed, and many of the specific differentially expressed proteins were involved in cell-signaling pathways such as Notch and Wnt signaling, which are known to regulate cellular development. Furthermore, cytoskeletal proteins profilin, DSTN, SPECC1, and DAAM2 showed increased protein levels in osteoblasts differentiated at 42 °C as compared with 37 °C, and these cells, while they appeared to accumulate calcium, did not organize into a whorl agglomerate as is typically seen at physiological temperatures. This altered proteome composition observed suggests that heat stress could have long-term impacts on cellular development. We propose that this in vitro stem cell culture model of cell differentiation is useful for investigating molecular mechanisms that impact cell development in response to stressors.     

Quaternary Structure and Hetero-Oligomerization of Recombinant Human Small Heat Shock Protein HspB7 (cvHsp)

In this study, a reliable and simple method of untagged recombinant human HspB7 preparation was developed. Recombinant HspB7 is presented in two oligomeric forms with an apparent molecular weight of 36 kDa (probably dimers) and oligomers with an apparent molecular weight of more than 600 kDa. By using hydrophobic and size-exclusion chromatography, we succeeded in preparation of HspB7 dimers. Mild oxidation promoted the formation of large oligomers, whereas the modification of Cys 126 by iodoacetamide prevented it. The deletion of the first 13 residues or deletion of the polySer motif (residues 17–29) also prevented the formation of large oligomers of HspB7. Cys-mutants of HspB6 and HspB8 containing a single-Cys residue in the central part of the β7 strand in a position homologous to that of Cys137 in HspB1 can be crosslinked to the wild-type HspB7 through a disulfide bond. Immobilized on monoclonal antibodies, the wild-type HspB6 interacted with the wild-type HspB7. We suppose that formation of heterodimers of HspB7 with HspB6 and HspB8 may be important for the functional activity of these small heat shock proteins.     

复合装药威力性能试验分析

为研究复合装药威力性能,设计由高爆速理想炸药和含铝炸药组成的内外复合装药结构.在分析复合装药作用原理的基础上,采用压力传感器法研究不同装药结构的冲击波超压性能,利用靶网测速法研究不同装药结构对破片初速的影响.试验结果表明:相对于单一含铝炸药,外层高爆速炸药、内层由含铝炸药组成的复合装药结构可显著提高冲击波超压值和破片初速.     

CL-20基含铝炸药水下爆炸实验研究与数值模拟（英）

为了研究含铝粉与不含铝粉的六硝基六氮杂异伍兹烷（CL-20）基高聚物粘结炸药（PBXs）的水下爆炸过程,制备了含铝量分别为0和15%的两种炸药,设计了一个水下爆炸实验装置,得到了炸药的冲击波压力历程、气泡周期和气泡脉动图。计算了两种炸药的冲击波能量、气泡能量和水下爆炸总能量。采用AUTODYN软件模拟了水下爆炸过程。结果表明,当铝含量从0增大到15%时,水下爆炸总能量由1.4倍TNT当量增加到1.7倍TNT当量。气泡脉动过程中,时间从49.5 ms到49.8 ms时,含铝炸药气泡内产生火光。含铝炸药与非含铝炸药超压分别为15.16 MPa与15.51 MPa,气泡二次压力分别为2.25 MPa与2.35 MPa,气泡周期分别为50.20 ms与46.76 ms,气泡最大半径分别为67.87 cm与60.27 cm;仿真得到含铝炸药与非含铝炸药参数超压分别为14.90 MPa与15.14 MPa,气泡二次压力分别为2.16 MPa与2.27 MPa,气泡周期分别为49.32 ms与45.90 ms,气泡最大半径分别为66.32 cm与58.89 cm。实验与仿真结果吻合良好。