With increasing competition in international marine logistics service industry, the voice of improving marine logistics service for reducing operation cost and improving service quality is much higher. Aiming at the marine logistics services between Weihai and Korea, this paper makes a case study to design a BIRIS-based public platform for this service. Firstly, current business scenarios of Sino-Korea marine logistics services are briefly analyzed and some business issues that need to be solved urgently are listed, e.g., lack of effective communication channel between cargo owners and various service providers, low coordination efficiency between different service providers etc. Aiming at these problems, a BIRIS based marine logistics service platform is designed. TO-BE business scenario, SOA techniques for developing such platform, and some examples of identifying services, designing service interfaces and designing portal for each service provider, are elaborately shown. 相似文献
To successfully manage today’s complex production systems it is essential to study operators’ perception of the system. The paper presents perceived production complexity assessed at seven manufacturing companies with the CompleXity Index (CXI) method. While other methods have measured product variants, layout, work content, tools and information items, CXI combines them into three areas. These three complexity areas (Station design, Work variance and Disturbance handling) help to create an understanding of the complex system by visualising how they contribute to complexity, and show the need to support the operators’ ability to handle the varying work. 相似文献
Context: The conventional liquid ophthalmic delivery systems exhibit short pre-corneal residence time and the relative impermeability to the cornea which leads to poor ocular bioavailability.
Objective: The aim of this study was to apply quality by design (QbD) for development of dexamethasone sodium phosphate (DSP) and tobramycin sulfate (TS)-loaded thermoresponsive ophthalmic in situ gel containing Poloxamer 407 and hydroxyl propyl methyl cellulose (HPMC) K4M for prolonging the pre-corneal residence time, ocular bioavability and decreases the frequency of administration of dosage form. The material attributes and the critical quality attributes (CQA) of the in situ gel were identified. Central composite design (CCD) was adopted to optimize the formulation.
Materials and methods: The ophthalmic in situ forming gels were prepared by cold method. Materials attributes were the amount of Poloxamer 407 and HPMC and CQA identified were Gel strength, mucoadhesive index, gelation temperature and % of drug release of both drug.
Results and discussion: Optimized batch (F*) containing 16.75% poloxamer 407 and 0.54% HPMC K4M were exhibited all results in acceptable limits. Compared with the marketed formulation, optimized in situ gel showed delayed Tmax, improved Cmax and AUC in rabbit aqueous humor, suggesting the sustained drug release and better corneal penetration and absorption.
Conclusion: According to the study, it could be concluded that DSP and TS would be successfully formulated as in situ gelling mucoadhesive system for the treatment of steroid responsive eye infections with the properties of sustained drug release, prolonged ocular retention and improved corneal penetration. 相似文献
Well-founded criticisms of the Consumer Reports (CR; 1995) study of psychotherapy include possible bias of the CR sample; limitations of self-report; and the limitations of cross-sectional, retrospective data. Poorly founded criticisms concern "consumer satisfaction" and the claim that the remarkably good effects of long-term therapy resulted from spontaneous remission, that psychotherapy effects were small, and that nondoctoral providers did as well as doctoral-level providers. Both the experimental method (efficacy) and the observational method with causal modeling (effectiveness) answer complementary questions, and they both do so by eliminating alternative possible causes. Efficacy studies, however, cannot test long-term psychotherapy because long-term manuals cannot be written and patients cannot be randomized into two-year-long placebo controls, so the "empirical validation" of long-term therapy will likely come from effectiveness studies. Such studies of long-term therapy, of qualifications of providers, and of clinical judgment versus case management are urgently needed as practice confronts managed care. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献