适用于河流治理的地面廊道污水处理系统的设计

地面廊道污水处理系统类似于人工湿地技术，其优点在于该系统应用于污染河流的治理时，对河流地形适应性非常强；另外系统四周不透水的墙体结构使整个廊道起着氧化塘的作用，并且沿坡降由好氧塘逐渐过渡到厌氧塘。本文重点介绍该处理系统的设计，主要包括廊道的选址．水生植物的选择．廊道最佳长度及运行参数的确定。     

浅谈中国焦化废水处理技术进展及其应用

介绍了目前中国焦化废水治理现状,综述了焦化废水治理技术中的生物法、化学法、生物一化学法和生物脱氮技术的原理、应用及其进展,并提出了各种方法存在的问题。     

现场预制桥梁T梁开裂分析、处理及预防

对后张法现场预制T梁的裂缝进行描述,从混凝土的原材料、配合比、施工和养护,环境条件等方面分析引起T梁开裂的原因,提出了处理办法及预防措施.对指导施工具有积极意义.     

Application of Proteomics in Pancreatic Ductal Adenocarcinoma Biomarker Investigations: A Review

Pancreatic ductal adenocarcinoma (PDAC), a highly aggressive malignancy with a poor prognosis is usually detected at the advanced stage of the disease. The only US Food and Drug Administration-approved biomarker that is available for PDAC, CA 19-9, is most useful in monitoring treatment response among PDAC patients rather than for early detection. Moreover, when CA 19-9 is solely used for diagnostic purposes, it has only a recorded sensitivity of 79% and specificity of 82% in symptomatic individuals. Therefore, there is an urgent need to identify reliable biomarkers for diagnosis (specifically for the early diagnosis), ascertain prognosis as well as to monitor treatment response and tumour recurrence of PDAC. In recent years, proteomic technologies are growing exponentially at an accelerated rate for a wide range of applications in cancer research. In this review, we discussed the current status of biomarker research for PDAC using various proteomic technologies. This review will explore the potential perspective for understanding and identifying the unique alterations in protein expressions that could prove beneficial in discovering new robust biomarkers to detect PDAC at an early stage, ascertain prognosis of patients with the disease in addition to monitoring treatment response and tumour recurrence of patients.     

Pharmacogenomics of Anti-TNF Treatment Response Marks a New Era of Tailored Rheumatoid Arthritis Therapy

Rheumatoid arthritis (RA) is the most commonly occurring chronic inflammatory arthritis, the exact mechanism of which is not fully understood. Tumor Necrosis Factor (TNF)-targeting drugs has been shown to exert high effectiveness for RA, which indicates the key importance of this cytokine in this disease. Nevertheless, the response to TNF inhibitors varies, and approximately one third of RA patients are non-responders, which is explained by the influence of genetic factors. Knowledge in the field of pharmacogenomics of anti-TNF drugs is growing, but has not been applied in the clinical practice so far. Different genome-wide association studies identified a few single nucleotide polymorphisms associated with anti-TNF treatment response, which largely map genes involved in T cell function. Studies of the gene expression profile of RA patients have also indicated specific gene signatures that may be useful to develop novel prognostic tools. In this article, we discuss the significance of TNF in RA and present the current knowledge in pharmacogenomics related to anti-TNF treatment response.     

糖渍野木瓜鲜切片加工及保鲜工艺研究

目的 优化糖渍野木瓜的制作工艺和保鲜工艺参数,并评估其货架期。方法 以糖液质量分数、超声糖渍时间、真空糖渍时间为因素,进行正交实验,筛选出糖渍野木瓜鲜切片的最佳制作工艺。在最佳糖渍工艺基础上,筛选糖渍野木瓜鲜切片的保鲜处理工艺参数。在糖液中添加纳他霉素和D-异抗坏血酸钠,真空包装后巴氏杀菌。根据筛选出的最佳工艺参数制作产品,并进行产品检验。结果 糖渍野木瓜鲜切片最佳工艺参数：超声糖渍时间为60 min,真空糖渍时间为90 min,糖液质量分数为40%,纳他霉质量浓度为60 mg/L,D-异抗坏血酸钠质量浓度为200 mg/L,杀菌条件为70℃、30 min。结论 该工艺生产出的糖渍野木瓜鲜切片相较于市售产品具有更高的安全性和更长的货架期。     

纳滤膜在微污染水处理中的应用

纳滤是近十几年来才发展起来的一种新型的介于超滤与反渗透之间的膜水处理技术,由于其具有能截留低分子有机物和多价盐,低压操作和离子选择性等优点,在水处理中被越来越多地应用和研究。本文在介绍纳滤膜的分离机理的基础上综述了纳滤膜技术在微污染水处理方面的应用研究进展,并对其处理过程中的影响因素进行了分析,最后指出了它的应用前景。     

MicroRNA Cross-Involvement in Acne Vulgaris and Hidradenitis Suppurativa: A Literature Review

Acne Vulgaris (AV) and Hidradenitis suppurativa (HS) are common chronic inflammatory skin conditions that affect the follicular units that often coexist or are involved in differential diagnoses. Inflammation in both these diseases may result from shared pathways, which may partially explain their frequent coexistence. MicroRNAs (miRNAs) are a class of endogenous, short, non-protein coding, gene-silencing or promoting RNAs that may promote various inflammatory diseases. This narrative review investigates the current knowledge regarding miRNAs and their link to AV and HS. The aim is to examine the role of these molecules in the pathogenesis of AV and HS and to identify possible common miRNAs that could explain the similar characteristics of these two diseases. Five miRNA (miR-155 miR-223-, miR-21, and miRNA-146a) levels were found to be altered in both HS and AV. These miRNAs are related to pathogenetic aspects common to both pathologies, such as the regulation of the innate immune response, regulation of the Th1/Th17 axis, and fibrosis processes that induce scar formation. This review provides a starting point for further studies aimed at investigating the role of miRNAs in AV and HS for their possible use as diagnostic-therapeutic targets.     

基质配置对潮汐流人工湿地处理稀土矿山含氨氮地表水效果的影响

人工湿地（Constructed Wetland,CW）可对稀土矿工业开采遗留的氨氮污染废水进行高效生态化处理。添加铁碳和生物炭材料构建四组潮汐流人工湿地,研究不同淹没空置比（F/D）条件下铁碳和生物炭添加方式及位置对湿地脱氮效果的影响。结果表明,控制F/D=6 h/6 h（水流淹没湿地床体6 h后排水空置6 h后下一批次进水）,进水NH4+-N为40±2.37 mg/L, CWFeC2（NO.2 Fe-C substrate Constructed Wetland）对NH4+-N有较好的脱氮效果,平均去除率86.44%±3.28%,最高去除率89.72%,CWB（Biochar based Constructed Wetland）对总氮（TN）有较好的去除效果,最高去除率51.12%。高通量测序分析结果显示,生物炭基质湿地Alpha多样性指数各指标均大于铁碳基质湿地。具有固氮作用的变形菌门在CWFeC1和CWFeC2中占比70%以上,在CWB中占比40%以上,是最主要的脱氮菌群。在CWB中发挥好氧硝化作用的硝化螺旋菌占比15%以上,酸杆菌门存在近10%,能适应酸性条件且具有一定脱氮作用。本实验的进行对稀土矿山含氨氮废水的生态化处理具有一定的参考应用价值,为相关领域填补空缺并提供一定的数据支持。     

处理污水时膜污染问题的试验研究

根据膜生物反应器中膜污染的几种类型,分析了膜污染形成机理及影响因素,并总结了几种防止和处理膜污染的方法。