Numerical study of hydrodynamic flow of a Casson nanomaterial past an inclined sheet under porous medium

The main aim of the current paper is to investigate the mass and heat transportation of a Casson nanomaterial generated by the inclination of the surface. The magnetic field effect along with suction or injection are considered. The working nanomaterial is taken into consideration based on the concept of the Buongiorno nanofluid theory, which explores the thermal efficiencies of liquid flows under movement of Brownian and thermophoretic phenomena. The emergent system of differential expressions is converted to dimensionless form with the help of the appropriate transformations. This system is numerically executed by the implementation of Keller–Box and Newton's schemes. A good agreement of results can be found with the previous data in a limiting approach. The behavior of the physical quantities under concern, including energy exchange, Sherwood number, and wall shear stress are portrayed through graphs and in tabular form. The Nusselt number and Sherwood number are found to diminish against the altered magnitudes of Brownian motion and the inclination parameter. Moreover, the velocity profile decreases with the growth of the inclination effect. In the same vein, the buoyancy force and solutal buoyancy effects show a direct relation with the velocity field. The outcomes have promising technological uses in liquid‐based systems related to stretchable constituents.     

Effects of Electrospinning Parameters on Gelatin/Poly(ϵ‐Caprolactone) Nanofiber Diameter

An electrospinning procedure was carried out to fabricate gelatin/poly(?‐caprolactone) (Gt/PCL) nanofibers. Response surface methodology based on a three‐level, four‐variable Box‐Behnken design technique was used to model the resultant diameter of the as‐spun nanofibers. A second‐order model was obtained to describe the relationship between the fiber diameter and the electrospinning parameters, namely Gt concentration, PCL concentration, content of acetic acid in the overall solvent, and content of Gt solution in the blend solution. The individual and the interactive effects of these parameters on the fiber diameter were determined. Validation experiments verified the accuracy of the model which provided a simple and effective method for fabricating nanofibers with a controllable and predictable fiber diameter.     

On the analysis of fracture mechanisms and mechanical behavior of AA5083-based tri-modal composites reinforced with 5 wt.%B4C and toughened by AA5083 and AA2024 coarse grain phases

In this article, the influence of AA2024 and AA5083 coarse grains on mechanical properties and failure mechanisms of AA5083-5wt. %B₄C tri-modal composite has been discussed. AA2024 and AA5083 powders (<100 µm) were added to mechanically milled AA5083-5 wt.%B₄C powders in 25 and 50 wt.% and the mixtures were consolidated using the hot press and hot extrusion techniques. Results indicated that by adding AA2024 and AA5083 powders as coarse grains, hardness and tensile strength of AA5083-5 wt.%B₄C composite decreased but ductility increased. Moreover, by adding AA2024 powders as coarse grains, fracture mode changed and cracks tended to grow through along AA2024/AA5083-5 wt.%B₄C interface rather than being arrested or deflected. It seemed that dislocation mobility and the interface between coarse grains and ultra-fine grains had the main role in determining the mechanical properties and failure mechanisms in tri-modal AA5083-B₄C composites.     

Formulation,optimization, hemocompatibility and pharmacokinetic evaluation of PLGA nanoparticles containing paclitaxel

Objective: Paclitaxel (PTX)-loaded polymer (Poly(lactic-co-glycolic acid), PLGA)-based nanoformulation was developed with the objective of formulating cremophor EL-free nanoformulation intended for intravenous use.

Significance: The polymeric PTX nanoparticles free from the cremophor EL will help in eliminating the shortcomings of the existing delivery system as cremophor EL causes serious allergic reactions to the subjects after intravenous use.

Methods and results: Paclitaxel-loaded nanoparticles were formulated by nanoprecipitation method. The diminutive nanoparticles (143.2?nm) with uniform size throughout (polydispersity index, 0.115) and high entrapment efficiency (95.34%) were obtained by employing the Box–Behnken design for the optimization of the formulation with the aid of desirability approach-based numerical optimization technique. Optimized levels for each factor viz. polymer concentration (X1), amount of organic solvent (X2), and surfactant concentration (X3) were 0.23%, 5?ml %, and 1.13%, respectively. The results of the hemocompatibility studies confirmed the safety of PLGA-based nanoparticles for intravenous administration. Pharmacokinetic evaluations confirmed the longer retention of PTX in systemic circulation.

Conclusion: In a nutshell, the developed polymeric nanoparticle formulation of PTX precludes the inadequacy of existing PTX formulation and can be considered as superior alternative carrier system of the same.     

Influence of radiation and viscous dissipation on MHD heat transfer Casson nanofluid flow along a nonlinear stretching surface with chemical reaction

The present article investigates the influence of Joule heating and chemical reaction on magneto Casson nanofluid phenomena in the occurrence of thermal radiation through a porous inclined stretching sheet. Consideration is extended to heat absorption/generation and viscous dissipation. The governing partial differential equations were transformed into nonlinear ordinary differential equations and numerically solved using the Implicit Finite Difference technique. The article analyses the effect of various physical flow parameters on velocity, heat, and mass transfer distributions. For the various involved parameters, the graphical and numerical outcomes are established. The analysis reveals that the enhancement of the radiation parameter increases the temperature and the chemical reaction parameter decreases the concentration profile. The empirical data presented were compared with previously published findings.     

起重机箱形梁贯穿裂纹尖端前沿形状简化研究

以36t集装箱门式起重机箱形梁为研究对象,针对结构的疲劳裂纹,利用有限元分析软件Abaqus建立了起重机箱形梁的整体有限元模型和裂纹子模型,采用相互作用积分法分别求解了下盖板和腹板上实际斜裂纹以及相应简化等长裂纹的应力强度因子K_I,研究了起重机箱形梁贯穿裂纹尖端前沿形状简化的合理性。通过对比分析计算结果,发现简化等长裂纹尖端的最大应力强度因子K_I,总是大于实际斜裂纹尖端的应力强度因子值,说明将实际斜裂纹简化成等长裂纹是有效可行的。为起重机箱形梁结构进行断裂分析提供了依据。     

Boundary layer flow over a finite flat plate with a constant slip velocity

Two-dimensional incompressible laminar flow induced by a constant slip velocity on the surface of a finite flat plate is studied both analytically and numerically for large Reynolds numbers. It turned out that the thickness of the thin layer downstream of the trailing edge increases in square root of the distance from the trailing edge. Numerical integration of the boundary layer equations for the whole flow field confirmed two asymptotic natures of the flow field; near the trailing edge the analytic result is approached, and far downstream of the plate the jet flow solution is attained.     

Preparation and optimization of a novel microbead formulation to improve solubility and stability of curcumin

Curcumin is an active ingredient which is poorly water-soluble, leading to a low oral bioavailability. The aim of this research was to prepare a novel microbead formulation, and to solubilize, solidify, and improve storage stability of curcumin. Firstly, curcumin was solubilized with Kolliphor^TM RH40 and then microencapsulated by cross linking of sodium alginate with calcium chloride. A three-factor, three-level Box–Behnken design was employed to acquire the optimum microbead formulation, namely the best entrapment efficiency and in vitro curcumin release. The independent variables were sodium alginate concentration, calcium chloride concentration, and the weight of curcumin solution, while the dependent variables were entrapment efficiency and in vitro curcumin release. The optimized microbead formulation was 2.06% sodium alginate, 24.33% calcium chloride, and 1.28 g curcumin solution (containing curcumin and RH40 with a ratio of 1:22, g/g). Results showed that high concentrations of sodium alginate and calcium chloride could increase the entrapment efficiency. In vitro curcumin release decreased with increasing of sodium alginate as well as decreasing of calcium chloride. In conclusion, the optimum microbead formulation increased the solubility of curcumin and enhanced its stability, and achieved a high entrapment efficiency and in vitro curcumin release.     

Prediction and optimization of nanoclusters-based thermal conductivity of nanofluids: Application of Box–Behnken design (BBD)

The existing models to predict the thermal conductivity of nanofluids are based on single particle diameter, whereas, in actual solutions, nanoparticles mostly exist in a cluster form. Experiments are carried out to observe the effects of various surfactants on stability, nanocluster formation, and thermal conductivity of Al₂O₃–H₂O nanofluid, which is found to be improved considerably with SDS surfactant. The prolonged sonication was not adequate to break the clusters of Al₂O₃ nanoparticles, into an average size of less than 163 nm, indicating the tendency of Al₂O₃ nanoparticles to remain in the form of clusters instead of individual nanoparticles of primary size of 20 nm. Response surface methodology has been employed to design and optimize the experimental strategy by taking volumetric concentration, temperature, and surfactant amount as the contributing factors. The developed model has been validated against the experimental data and the existing models with an accuracy level of ± 8% in the former case. Analysis reveals about the formation of nanoclusters and enhancement in thermal conductivity. The results confirmed that the model can predict thermal conductivity enhancement with an accuracy level of R square value of the order of 0.9766.     

Splines over regular triangulations in numerical simulation

We investigate the use of smooth spline spaces over regular triangulations as a tool in (isogeometric) Galerkin methods. In particular, we focus on box splines over three-directional meshes. Box splines are multivariate generalizations of univariate cardinal B-splines sharing the same properties. Tensor-product B-splines with uniform knots are a special case of box splines. The use of box splines over three-directional meshes has several advantages compared with tensor-product B-splines, including enhanced flexibility in the treatment of the geometry and stiffness matrices with stronger sparsity. Boundary conditions are imposed in a weak form to avoid the construction of special boundary functions. We illustrate the effectiveness of the approach by means of a selection of numerical examples.