Incorporating installation effects into the probability analysis of controlled modulus columns

This technical report presents the probabilistic analysis which integrates the Monte Carlo simulation (MCS) with random field theory to model the load–displacement behavior of Controlled Modulus Columns (CMCs) in overconsolidated Poznań clay. Presented study focuses on the practical aspects of statistical analysis of geotechnical data, numerical model development, and results evaluation. Variability and spatial distribution of geotechnical parameters are based directly on field and lab testing. The inherent variability of soil parameters obtained from geotechnical investigation at the site is similar to the values reported in worldwide datasets for clays. The extensive discussion about incorporation of installation effects into numerical modelling is made. It was found that proper incorporation of installation effects is governed by correct estimation of initial stress level and interface shear strength parameters. The Anisotropic Undrained Shear Strength (AUS) model which captures nonlinear behavior and anisotropy of soil (Krabbenhøft et al., 2019) is a good choice to model overconsolidated clay in intact and interface zones. The application of total stress approach, the AUS model, installation effects, and natural (inherent) variability of soil and interface parameters is sufficient to explain differences in CMC load – displacement behavior observed in the field.     

百万千瓦级核电站轴封型主泵整机集成试验验证优化方案研究

为确保主泵的安全性和可靠性,主泵整机在完成集成设计后需通过试验进行验证。文中介绍了主泵设计与验证的总体思路,提出了主泵工程样机需开展的整机试验项目。基于已有的试验条件,进行了主泵整机集成试验验证方案的优化和可行性分析。分析结果表明,在充分开展主泵各模块、子模块、部件和材料的试验与分析的基础上,可采用小流量试验方案进行主泵整机集成试验验证。     

溶剂法合成2-羟基-1-萘甲酸的工艺研究

以β-萘酚和氢氧化钠为原料,正辛烷为溶剂,合成了2-羟基-1-萘甲酸,纯度达98%以上。通过正交实验研究了反应压力、反应温度和反应时间对收率的影响,确定了优化的工艺条件:反应压力0.8 MPa,反应温度90℃,反应时间8 h,该条件下收率达82.83%。     

一种基于四边形面积坐标的四结点平面参变量单元

基于四边形面积坐标和广义协调原理,通过投影技术,并引入0~1区间上可连续变化的罚因子,构造了一款具有统一格式的四结点平面参变量单元AQGβ6-I。通过4组数值算例测试了单元性能,并将计算结果与许多著名单元对比表明：时,单元退化为原始格式,具有原始单元的全部优良性能;时,单元可以精确通过强分片检验,此时性能与许多著名单元基本相当,显著优于传统平面四结点等参单元(Q4);时,单元兼具较好的抗网格畸变能力和收敛速度。单元的构造方式对缓解一个有限元难题(通过常分片检验的四结点单元在弯曲问题中表现欠佳,而在弯曲问题中表现非常好的单元无法通过强分片检验)提供了有益思路。     

自密实混凝土圆环约束收缩试验研究

进行了密封与沿环外侧面干燥两种条件下的自密实混凝土圆环约束收缩试验,分别研究自密实混凝土试件在自生收缩单独作用下,以及在干燥与自生收缩共同作用下钢环应变随混凝土龄期的发展规律及开裂性能,并与普通混凝土进行比较。配合比参数包括粉煤灰掺量、粉煤灰和矿渣复掺掺量、水胶比。揭示了配合比参数在两种不同条件下对钢环应变和开裂龄期的影响规律,并提出以“标准化”的钢环应变曲线作为开裂趋势曲线,以开裂系数为0.95时的龄期为“名义开裂龄期”作为圆环试验中混凝土开裂指标的建议。研究结果还表明,同一配合比参数对干燥约束收缩与自生约束收缩的作用有可能一致,也有可能完全相反,因此有必要对两种收缩分别研究;该文提出的“开裂趋势曲线”和“名义开裂龄期”能综合混凝土开裂中“作用”和“抗力”两个方面的影响,从而对混凝土的开裂性能进行动态、定量、综合的评价。     

基于K-means聚类的风压系数快速分区方法

提出了一种基于K-means聚类的风压系数快速分区方法。K-means聚类要求事先给出聚类数目k值,在风压系数分区应用中存在局限性。采取两种措施进行改进：一是预先限制k值范围,实现所有k值下的快速聚类。二是采用有效性指标确定最佳k值。分别以平屋盖、鞍形屋盖的两种代表性来流工况为例,说明和验证了风压系数分区方法。结果表明：分区方法能很好地完成不同几何形状屋盖、不同来流工况、不同类型的风压系数分区。     

石榴酒发酵生产工艺及褐变研究

以石榴为原料,生产石榴果酒,并对石榴酒褐变进行研究和控制。采用单因素和正交实验方案对石榴果酒发酵过程中的主要影响因子进行分析,最佳发酵工艺为:果胶酶添加量为40mg/kg,发酵温度为24℃,二氧化硫添加量50mg/kg,酵母接种量为5%。其中发酵温度的影响具有显著性。石榴酒的褐变原因主要是酶促褐变和非酶促褐变,其中氧化过程是主要因素。通过减少氧化褐变底物能有效抑制褐变,最佳澄清剂为硅藻土,用量为0.10%。所得石榴果酒澄清透明,酸甜适中,香味纯正,具有石榴水果的独特风味。      

米胚油精炼工艺与精炼油理化指标分析

以米胚毛油为原料,经过脱蜡、脱胶、脱色和脱酸/脱臭得到精炼油。通过正交实验对脱胶工艺优化,确定了最优脱胶工艺:反应温度45℃,磷酸溶液加入量为0.2%,加水量为6%,反应时间40min;进而对脱色工艺中的吸附剂和溶剂筛选,确定了吸附剂和溶剂及用量:正己烷200mL,活性炭20g。精炼后米胚油,气味、色泽、理化指标均达到植物油国家卫生标准（GB2716-2005）,AV从70.9mg/g降至0.69mg/g,POV为132.52mmol/kg,IV为90.2g/100g,皂化值为162mg/g,不皂化物含量占0.82%,折射率1.4709。米胚油以油酸、亚油酸、棕榈酸为主,其中不饱和脂肪酸含量近80%,且精炼前后其脂肪酸组成无明显变化。      

Correlation between In Vitro Neutralization Assay and Serological Tests for Protective Antibodies Detection

Serological assays are useful in investigating the development of humoral immunity against SARS-CoV-2 in the context of epidemiological studies focusing on the spread of protective immunity. The plaque reduction neutralization test (PRNT) is the gold standard method to assess the titer of protective antibodies in serum samples. However, to provide a result, the PRNT requires several days, skilled operators, and biosafety level 3 laboratories. Therefore, alternative methods are being assessed to establish a relationship between their outcomes and PRNT results. In this work, four different immunoassays (Roche Elecsys^® Anti SARS-CoV-2 S, Snibe MAGLUMI^® SARS-CoV-2 S-RBD IgG, Snibe MAGLUMI^® 2019-nCoV IgG, and EUROIMMUN^® SARS-CoV-2 NeutraLISA assays, respectively) have been performed on individuals healed after SARS-CoV-2 infection. The correlation between each assay and the reference method has been explored through linear regression modeling, as well as through the calculation of Pearson’s and Spearman’s coefficients. Furthermore, the ability of serological tests to discriminate samples with high titers of neutralizing antibodies (>160) has been assessed by ROC curve analyses, Cohen’s Kappa coefficient, and positive predictive agreement. The EUROIMMUN^® NeutraLISA assay displayed the best correlation with PRNT results (Pearson and Spearman coefficients equal to 0.660 and 0.784, respectively), as well as the ROC curve with the highest accuracy, sensitivity, and specificity (0.857, 0.889, and 0.829, respectively).     

The Genotoxicity of Acrylfentanyl,Ocfentanyl and Furanylfentanyl Raises the Concern of Long-Term Consequences

Three fentanyl analogues Acrylfentanyl, Ocfentanyl and Furanylfentanyl are potent, rapid-acting synthetic analgesics that recently appeared on the illicit market of new psychoactive substances (NPS) under the class of new synthetic opioids (NSO). Pharmacotoxicological data on these three non-pharmaceutical fentanyl analogues are limited and studies on their genotoxicity are not yet available. Therefore, the aim of the present study was to investigate this property. The ability to induce structural and numerical chromosomal aberrations in human lymphoblastoid TK6 cells was evaluated by employing the flow cytometric protocol of the in vitro mammalian cell micronucleus test. Our study demonstrated the non-genotoxicity of Fentanyl, i.e., the pharmaceutical progenitor of the class, while its illicit non-pharmaceutical analogues were found to be genotoxic. In particular, Acrylfentanyl led to a statistically significant increase in the MNi frequency at the highest concentration tested (75 μM), while Ocfentanyl and Furanylfentnyl each did so at both concentrations tested (150, 200 μM and 25, 50 μM, respectively). The study ended by investigating reactive oxygen species (ROS) induction as a possible mechanism linked to the proved genotoxic effect. The results showed a non-statistically significant increase in ROS levels in the cultures treated with all molecules under study. Overall, the proved genotoxicity raises concern about the possibility of serious long-term consequences.