Platelet Derivatives and the Immunomodulation of Wound Healing

Besides their primary role in hemostasis, platelets contain a plethora of immunomodulatory molecules that profoundly affect the entire process of wound repair. Therefore, platelet derivatives, such as platelet-rich plasma or platelet lysate, have been widely employed with promising results in the treatment of chronic wounds. Platelet derivatives provide growth factors, cytokines, and chemokines targeting resident and immigrated cells belonging to the innate and adaptive immune system. The recruitment and activation of neutrophils and macrophages is critical for pathogen clearance in the early phase of wound repair. The inflammatory response begins with the release of cytokines, such as TGF-β, aimed at damping excessive inflammation and promoting the regenerative phase of wound healing. Dysregulation of the immune system during the wound healing process leads to persistent inflammation and delayed healing, which ultimately result in chronic wound. In this review, we summarize the role of the different immune cells involved in wound healing, particularly emphasizing the function of platelet and platelet derivatives in orchestrating the immunological response.     

Hydroxylation of Progesterone and Its Derivatives by the Entomopathogenic Strain Isaria farinosa KCh KW1.1

Progesterone biotransformation is worth studying because of the high industrial value of its derivatives. This study investigated the catalytic ability of the entomopathogenic filamentous fungus strain Isaria farinosa KCh KW1.1 to transform progesterone derivatives: 11α-hydroxyprogesterone, 17α-hydroxyprogesterone, 16α,17α-epoxyprogesterone and pregnenolone. In the culture of Isaria farinosa KCh KW1.1, 11α-hydroxyprogesterone was effectively transformed into only one product: 6β,11α-dihydroxyprogesterone. Transformation of 17α-hydroxyprogesterone gave three hydroxy derivatives: 6β,17α-dihydroxyprogesterone, 12β,17α-dihydroxyprogesterone and 6β,12β,17α-trihydroxyprogesterone. Two products: 6β-hydroxy-16α,17α-epoxyprogesterone and 6β,11α-dihydroxy-16α,17α-epoxyprogesterone, were obtained from the 16α,17α-epoxyprogesterone transformation. We isolated two compounds from the biotransformation medium with pregnenolone: 11α-hydroxy-7-oxopregnenolone and 5α,6α-epoxy-3β,11α-dihydroxypregnan-7,20-dione. In this study, we observed only mono- and dihydroxy derivatives of the tested substrates, and the number of obtained products for each biotransformation did not exceed three.     

内蒙古大兴安岭根河植被覆盖度动态变化及影响因素的分析

研究植被覆盖度（Fractional Vegetation Cover,FVC）动态变化,可增强了解森林群落的抵抗力和恢复力,为森林生态系统定量评价提供科学依据。基于像元二分模型、Landsat-5 TM（2006、2010）及高分一号（GF-1,2016）数据估算了3个时期的根河市FVC,引入变化率和动态度2个指标评价其动态变化情况,并且分析了多因素对该变化的影响。实验结果显示：中度以上等级占总面积80%以上,2016年低、较低、中度、较高、高等级FVC分别为1 645.02、1 655.97、3 536.59、5 556.87、7507.15 km²。采用0.2 m航空CCD影像进行植被/非植被点提取后,针对2016年的FVC估算结果进行交叉验证的精度为0.92。变化分析结果显示：除部分地区外（敖鲁古雅）,2006~2016 年间FVC变化整体上呈增加态,尤其是高等级增加了1 668.78 km²。综合来看,根河市植被覆盖良好,多重因素共同影响其动态变化,局部FVC对火灾干扰的变化极为敏感,低海拔和平坡FVC明显降低,与人类生产生活密切相关。     

Sensitivity analysis of nonlinear fractional order control systems with state delay

In this paper, we consider a class of nonlinear fractional order control system with delay in state variable. Existence and uniqueness of solution are shown by using method of steps. The sensitivity of the state and control with respect to the parameters of the system is shown. Finally, analytical results are substantiated by numerical examples.     

P38促细胞分裂蛋白酶活性抑制剂的分子对接及3D-QSAR研究(英文)

运用分子对接方法研究了26个以嘧啶基咪唑环为基底的一系列同源化合物与p38促细胞分裂蛋白酶晶体结构的结合模式。采用比较分子力场分析法(CoMFA)对选取的对接优势构象进行三维定量构效关系(3D-QSAR)研究。建立了3D-QSAR的CoMFA模型,其非交叉验证系数r~2为0.986,交叉验证相关系数q~2为0.755,外部验证的标准偏差(SD为0.13,表明该模型合理、可信,并具有良好的预测能力。有趣的是,配体与活性周围氨基酸残基4个距离之和与其活性之间具有良好的线性关系(R~2=0.752),揭示了配体分子大小及与氨基酸残基结合的紧密程度对化合物的抑制活性起着主要的作用。最后,根据研究总结的规律设计了4个具有潜在高活性的嘧啶基咪唑衍生物。研究结果可为实验工作者合成新药提供理论有意义的理论参考。     

白藜芦醇糖苷类衍生物的设计与合成

以白藜芦醇及其类似物紫檀芪为原料,采用Schmidt成苷法、相转移催化法,分别与溴代糖和乙酰氨基糖反应,得紫檀芪乙酰葡萄糖苷和(E)-5,4'-二叔丁基二甲基硅基-3-(2"-乙酰氨基-3",4",6"-三乙酰葡萄糖二苯乙烯,其结构经红外光谱、核磁共振氢谱和质谱表征.     

Halochromic Behavior and Anticancer Effect of New Synthetic Anthocyanidins Complexed with β-Cyclodextrin Derivatives

Anthocyanidins, the aglycons of anthocyanins, are known, beyond their function in plants, also as compounds with a wide range of biological and pharmacological activities, including cytostatic effect against various cancer cells. The nature and position of the substituents in the flavylium cation is essential for such biological properties, as well as the equilibrium between the multistate of the different chemical species that are generated by the flavylium cation, including quinoidal base, hemiketal, and cis- and trans-chalcones. In this work, eight new flavylium derivatives were synthesized, characterized for confirmation of the structure by FT-IR and 2D-NMR, and investigated in vitro as possible cytostatic compounds against HCT116 and HepG2 cancer cells. The most active two compounds were explored for their halochromic properties that can influence the biological activity and subjected to molecular encapsulation in β-cyclodextrin derivatives in order to increase their solubility in water and bioavailability. The anticancer effect was influenced by the position (6-, 7-, or 8-) of the methoxy group in the β-ring of the methoxy-4′-hydroxy-3′-methoxyflavylium cation, while the study of the halochromic properties revealed the important role played by the chalcone species of the pH-dependent multistate in both the uncomplexed and inclusion complex forms of these anthocyanidins.     

Concurrent Blind Channel Equalization in Impulsive Noise Environments

In some communication systems the trans- mitted signal is contaminated by impulsive noise with a non-Gaussian distribution. Non-Gaussian noise caused significant performance degradation to communication re- ceivers. The new constant modulus blind equalizer based on Fractional lower-order statistics of the equalizer input, which is defined as FLOS_CMA, is able to mitigate impul- sive channel noise while restoring the constant modulus character of the transmitted communication signal. How- ever, like the Constant modulus algorithm （CMA）, the steady-state Mean square error （]VISE） of the FLOS_CMA algorithm may not be sufficient low for the system to ob- tain adequate performance. This paper proposes a con- current equalizer, in which a Decision-directed least mean p norm （DD_LMP） equalizer operates cooperatively with a FLOS_CMA equalizer, controlled through a non-linear link. Simulation results using M-QAM and 8-PSK signal- ing have shown that besides the capability of compensating the phase offset, the proposed concurrent FLOS_CMA and DD_LMP blind equalizer has faster convergence rate and lower steady-state MSE than the FLOS_CMA approach.     

密度泛函理论和从头计算法研究环戊二烯衍生物气态酸度及其取代基效应

用B3LYP／6-311G(2df,p)／／B3LYP／631 G*和MP2／6-311G(d,p)／／B3LYP／6-31 G*方法准确地预测了9个系列的环戊二烯衍生物(R=CN,CF3,CHO,C283,F,SiH3,H,CH3,OH,NH2)的C-H键的酸度。环戊二烯衍生物气态酸度的范围从284.9 kcal／mol (化合物5a)到357.24kcal／mol(化合物7j),分析取代基的电性、数量以及位置的影响得到了9个QSAR方程。这些数据有助于我们设计以及合成一些有机酸,并有助于深刻理解相关反应中环戊二烯衍生物的性质。     

3D虚拟技术在包装设计中的应用

目的以笔者带领团队为南京博物院设计文化创意衍生产品及其包装设计作为探讨对象,探讨了包装设计中的3D虚拟技术。方法从3D虚拟技术的优势出发,以实践方法,挖掘包装设计实现过程中的3D虚拟技术。结论随着数字技术的发展、推广和应用,3D虚拟技术影响着艺术设计的各个领域,包装设计不仅仅需要3D技术帮助其虚拟实现,更重要的是推动包装设计全程数字化实现。