一种数控精密电阻源的设计与实现

设计了一种数控精密电阻源,选择了一种使用继电器切换精密电阻的电路结构,并提出了消除精密电阻初始阻值误差和继电器接触电阻影响的软件校准方法.采用较少的继电器和精密电阻,实现了高精度可变电阻输出.输出电阻值范围为80.00～260.00 Ω,覆盖-50 ～430℃范围内Pt100的阻值变化,具有0.01 Ω步进,误差小于±0.02 Ω,能够广泛地应用于Pt100测温仪表的测试和校准.     

Improving the Management of Endometrial Cancer Patients through the Use of Liquid Biopsy Analyses: A Case Report

Endometrial cancer (EC) is the 4th most common neoplasm of the female genital tract, with 15–20% of patients being of high risk of recurrence which leads to a significant decrease in patient survival. Current therapeutic options for patients with EC are poor, being the combined therapy of carboplatin and paclitaxel the standard of care, with limited efficacy. Therefore, new therapeutic options and better monitoring tools are needed to improve the management of the disease. In the current case report, we showcase the value of liquid biopsy analyses in a microsatellite instability EC patient with initially good prognosis that however underwent rapid progression disease within 6 months post-surgery; through the study of plasma cfDNA/ctDNA dynamics to assess the tumour evolution during treatment, as well as the study of the uterine aspirate as a valuable sample that captures the intra-tumour heterogeneity that allows a comprehensive genomic profiling of the disease to identify potential therapeutic options. Furthermore, preclinical models were generated at the time of tumour progression to assess the efficacy of the identified targeted therapies.     

全景图像拼接的网络化感知节点自主定位系统

分析网络化感知系统节点定位问题的特殊性,针对深空探测环境未知的问题,提出利用全景图像重合度来修正信号衰减模型,提高测距精度;提出一种修正的高精度节点自主定位算法来解决多移动节点协同定位问题,该算法是把切圆法引入到基于全景图片重合度的RSSI修正定位方法中。当多个感知节点定位时,根据视距近似原则选择定位锚节点来进行H-CM算法,仿真结果表明该定位方案可以有效提高感知节点的定位精度。     

不确定规则推理在预测算法中的应用

文章针对海洋渔业资源的多种预测算法得到的结果集,提出了以框架的知识表示理论为基础的不确定规则推理预测系统修正算法,利用框架系统ＫＢＩＦ（Ｋｎｏｗｌｅｄｇｅ Ｂａｓｅ ｉｎ Ｆｒａｍｅ）的知识表示理论与黑板结构、不确定推理相结合对预测算法根据不同环境参数进行多种方式的修正,可以对系统预测结果进行有效的分析,以期得到更好的应用。     

Web上分布式领域组件的框架表示

文章采用知识表示中的框架表示法,结合谓词产生式,语义网络等手段,提出了一个具有网络分布式及Ｗｅｂ化构造特性的领域构架及组件的表示方法ＦＲＤＤＣ。应用ＦＲＤＤＣ实现的ＡＮＤ－ＣＡＳＥ模型表现了ＦＲＤＤＣ的自然性,结构性,Ｗｅｂ可操作性,容纳柔性及知识表达能力。     

Critical Review on Fatty Acid-Based Food and Nutraceuticals as Supporting Therapy in Cancer

Fatty acids have an important place in both biological and nutritional contexts and, from a clinical point of view, they have known consequences for diseases’ onset and development, including cancer. The use of fatty acid-based food and nutraceuticals to support cancer therapy is a multidisciplinary subject, involving molecular and clinical research. Knowledge regarding polyunsaturated fatty acids essentiality/oxidizability and the role of lipogenesis-desaturase pathways for cell growth, as well as oxidative reactivity in cancer cells, are discussed, since they can drive the choice of fatty acids using their multiple roles to support antitumoral drug activity. The central role of membrane fatty acid composition is highlighted for the application of membrane lipid therapy. As fatty acids are also known as biomarkers of cancer onset and progression, the personalization of the fatty acid-based therapy is also possible, taking into account other important factors such as formulation, bioavailability and the distribution of the supplementation. A holistic approach emerges combining nutra- and pharma-strategies in an appropriate manner, to develop further knowledge and applications in cancer therapy.     

NSCLC as the Paradigm of Precision Medicine at Its Finest: The Rise of New Druggable Molecular Targets for Advanced Disease

Standard treatment for advanced non-small cell lung cancer (NSCLC) historically consisted of systemic cytotoxic chemotherapy until the early 2000s, when precision medicine led to a revolutionary change in the therapeutic scenario. The identification of oncogenic driver mutations in EGFR, ALK and ROS1 rearrangements identified a subset of patients who largely benefit from targeted agents. However, since the proportion of patients with druggable alterations represents a minority, the discovery of new potential driver mutations is still an urgent clinical need. We provide a comprehensive review of the emerging molecular targets in NSCLC and their applications in the advanced setting.     

工业延期雷管延期精度的工艺探讨

介绍了工业延期雷管延期精度的影响因素,并对装配工艺中的装压药工艺方法、药剂变化原因、药剂时间变化规律和制药工艺控制进行了讨论。     

Challenges in Metabolomics-Based Tests,Biomarkers Revealed by Metabolomic Analysis,and the Promise of the Application of Metabolomics in Precision Medicine

Metabolomics helps identify metabolites to characterize/refine perturbations of biological pathways in living organisms. Pre-analytical, analytical, and post-analytical limitations that have hampered a wide implementation of metabolomics have been addressed. Several potential biomarkers originating from current targeted metabolomics-based approaches have been discovered. Precision medicine argues for algorithms to classify individuals based on susceptibility to disease, and/or by response to specific treatments. It also argues for a prevention-based health system. Because of its ability to explore gene–environment interactions, metabolomics is expected to be critical to personalize diagnosis and treatment. Stringent guidelines have been applied from the very beginning to design studies to acquire the information currently employed in precision medicine and precision prevention approaches. Large, prospective, expensive and time-consuming studies are now mandatory to validate old, and discover new, metabolomics-based biomarkers with high chances of translation into precision medicine. Metabolites from studies on saliva, sweat, breath, semen, feces, amniotic, cerebrospinal, and broncho-alveolar fluid are predicted to be needed to refine information from plasma and serum metabolome. In addition, a multi-omics data analysis system is predicted to be needed for omics-based precision medicine approaches. Omics-based approaches for the progress of precision medicine and prevention are expected to raise ethical issues.     

基于多元非线性回归算法的动车组变压器温度预测研究

对动车组状态参数进行预测是实现动车组数字化精准维修的重要前提之一.目前对动车组数据的利用方式主要以定量观测和定性分析为主,缺乏准确的状态预测量.为此,文章提出了一种基于多元非线性回归的预测算法,通过建立变压器温度预测模型,实现了变压器温度值的次日预测,并以此指导由温度导向的变压器日常运维项目.通过对比CRH5A型动车组...