Assessment of Paroxetine Molecular Interactions with Selected Monoamine and γ-Aminobutyric Acid Transporters

Thus far, many hypotheses have been proposed explaining the cause of depression. Among the most popular of these are: monoamine, neurogenesis, neurobiology, inflammation and stress hypotheses. Many studies have proven that neurogenesis in the brains of adult mammals occurs throughout life. The generation of new neurons persists throughout adulthood in the mammalian brain due to the proliferation and differentiation of adult neural stem cells. For this reason, the search for drugs acting in this mechanism seems to be a priority for modern pharmacotherapy. Paroxetine is one of the most commonly used antidepressants. However, the exact mechanism of its action is not fully understood. The fact that the therapeutic effect after the administration of paroxetine occurs after a few weeks, even if the levels of monoamine are rapidly increased (within a few minutes), allows us to assume a neurogenic mechanism of action. Due to the confirmed dependence of depression on serotonin, norepinephrine, dopamine and γ-aminobutyric acid levels, studies have been undertaken into paroxetine interactions with these primary neurotransmitters using in silico and in vitro methods. We confirmed that paroxetine interacts most strongly with monoamine transporters and shows some interaction with γ-aminobutyric acid transporters. However, studies of the potency inhibitors and binding affinity values indicate that the neurogenic mechanism of paroxetine’s action may be determined mainly by its interactions with serotonin transporters.     

猪肉内瘦肉增长素(MAT)的气相色谱-质谱检测(英文)

对用含瘦肉增长素 (MAT)的饲料喂养猪的猪肉样品进行检查。样品取自添加瘦肉增长素饲料喂养的 6头猪的不同部位 ,经生理盐水浸泡后 ,研磨成乳糜状 ,用乙醚提取。以 MT为内标进行 GC/ MS定量分析。实验结果表明 :41个样品呈阴性 ,只有 6号猪的右耳样品呈阳性 ,经内标定量计算 ,10 g右耳猪肉中含 2 .2 μg MAT。该实验提示可用 GC/ MS定性定量分析 MAT。     

基于4MAT系统的程序设计基础教学模式探讨

本文针对普遍存在的程序设计基础课程难学难教的问题,分析了存在一些影响因素,然后结合现代的认知学原理和信息加工理论,提出了一种基于4MAT系统的程序设计基础教学模式,并在教学中取得了很多积极的效果。     

Magnetic Microstructures of 2：17 Type Sm（Co,Fe,Cu,Zr）z Magnets Detected by Magnetic Force Microscopy

The magnetic microstructures of 2：17 type Sm （Co, Fe, Cu, Zr）z magnets were detected by magnetic force microscopy. Comparing the microstructures of the specimens eoated with and without Ta thin film before and after heat-treatment, it is found that： （a） as a protection layer, Ta coating layer about 20 nm thick can effectively restrain Sm volatilization under high temperature; （b） the stress built in the 2.17 type Sm-Co magnets during specimen preparation only affects some local parts of the domain structures; （c） the magnetic microstructures vary largely for specimens heat-treated at high temperature without Ta film coating due to Sm volatilization. In addition, by comparing with high coercivity Fe-Pt point tips, it is found that the Co-Cr thin-film tips are not suitable for detecting the magnetic microstructures of strong permanent magnets.     

β沸石的合成及其在裂化催化剂中的应用

采用水热法合成β沸石并进行了表征 ,比较了β沸石标样、自制β沸石和工业β沸石试样的各项物化指标。考察了裂化催化剂中引入 β沸石对催化活性和产品分布的影响 ,对USY沸石与ZSM -5、β沸石两种或多种沸石复配作为活性组分的裂化催化剂进行了较全面的评价和比较。结果表明 :β沸石引入裂化催化剂能明显提高裂化活性并降低积碳的生成 ,能增加异构烯烃 (iC4 =+iC5=)和汽油的产率 ,提高汽油辛烷值。USY、ZSM -5和 β沸石三者复配作为活性组分可提高裂化催化剂的综合指标 ,(iC4 =+iC5=)产率较参比催化剂提高 1 5 0 % ,汽油产品辛烷值 (RON)提高 2 0 5。     

人工神经网络在凸轮型线拟合中的应用

提出一种基于人工神经网络的凸轮型线拟合新方法。运用MATLAB软件工具 ,可在保证凸轮传动性能的前提下实现凸轮型线的高精度快速拟合。对 491型凸轮的拟合实例证明了该方法的可行性     

不同表面分维数Y型分子筛微反活性的研究

正如催化剂有粗糙不平的表面一样,一些Y型分子筛也有着粗糙不平的外表面。在描述催化剂的外表面时,经常使用表面分维数来表示催化剂表面的粗糙程度,借助表面分维数的概念来描述Y型分子筛的粗糙程度。在研究中使用相同的投料比时,合成出了不同形貌的NaY分子筛。这些NaY分子筛除了形貌不同外,其他物化性能相同。这些NaY经过稀土交换焙烧,最后制成催化剂。结果发现,这些催化剂的微反活性出现了差异。表面粗糙（表面分维数高）的Y型分子筛制成的催化剂有较高的活性。并且给出了这种现象可能的原因。     

电熔MgO及MAT细粉对刚玉质材料性能的影响

以电熔刚玉、电熔MgO及电熔MgO-Al2O3-TiO2细粉为原料,实验并研究了电熔MgO及电熔MgO-Al2O3-TiO2细粉的添加对刚玉质材料性能的影响.结果表明,经中、高温热处理后,添加MgO-Al2O3-TiO2细粉的刚玉质浇注料的各项性能明显好于添加MgO细粉的刚玉质浇注料.     

一种低信噪比条件下QPSK信号盲处理方法

提出了一种用于盲估计四相编码(Quaternary phase shift key,QPSK)载波频率的改进MAT(M-MAT)算法,并给出了一种新型QPSK信号码元估计方法。在没有接收信号先验知识的情况下,首先对QPSK信号粗估计出其载频重心和3dB带宽,并适度滤除带外噪声,之后利用MAT方法估计载频。在此基础上,利用每个码元带宽内相位幅度不变的特性,通过相邻码元的相位差值来估计码元变化。仿真结果表明,该载频估计方法估计精度高于传统的MAT方法,解码方法可以在低信噪比条件下,达到较高的解码精度。     

Fabrication and characterization of NEMS

We proposed a called“nano-fabrication based on MEMS technology”approach to realize the typical nano-electro- mechanical structures,such as integrated nano probe,ultrathin cantilever,silicon nano wire,and doubly clamped nano beam, to demonstrate the feasibility and advantages.We also introduced the characterization of nano structures based on laser vibrometer and piezoresistive effect,the latter method was first time applied to investigate a doubly daped nanobeam with a thickness of about 200 nm.