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High-shear wet granulation is a complex process that in turn makes scale-up a challenging task. Scale-up of high-shear wet granulation process has been studied extensively in the past with various different methodologies being proposed in the literature. This review article discusses existing scale-up principles and categorizes the various approaches into two main scale-up strategies – parameter-based and attribute-based. With the advent of quality by design (QbD) principle in drug product development process, an increased emphasis toward the latter approach may be needed to ensure product robustness. In practice, a combination of both scale-up strategies is often utilized. In a QbD paradigm, there is also a need for an increased fundamental and mechanistic understanding of the process. This can be achieved either by increased experimentation that comes at higher costs, or by using modeling techniques, that are also discussed as part of this review. 相似文献
64.
周玉丰 《自动化与仪器仪表》2011,(4):136-137
叶轮是泵的核心部分,泵的性能参数:流量、扬程、效率和特性曲线的形状等均与叶轮的设计有重要关系。本文对叶轮结构进行了有限元分析,准确且直观的得到了叶轮在载荷作用下的应力和应变,为叶轮的强度计算提供了可靠依据,验证了有限元建模方法和计算方法的正确性。 相似文献
65.
论述了离心通风机叶轮进口相对涡流的产生及其变化规律。分析了相对涡流与流体预旋及叶轮内流的内在联系。初步探讨了影响相对涡流变化规律的重要因素。 相似文献
66.
KYF—50充气机械搅拌式浮选机研制 总被引:9,自引:2,他引:9
探讨了矿物分选对大型浮选机的要求 ,分析了大型浮选机研制中所要解决的关键技术 ,详细阐述了在KYF - 5 0充气机械搅拌式浮选机设计过程中整机的主要结构和参数的选择 ,以及槽体、叶轮、定子等关键部件的结构和参数选择 ,介绍了KYF - 5 0充气机械搅拌式浮选机的工业试验结果 相似文献
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以对立式冲击粉碎机分级室内物料颗粒的动力学分析所得的分级粒径公式为基础 ,建立了分级叶轮优化设计的数学模型。通过运行具有通用性的复合形优化设计程序 ,对分级叶轮的结构进行优化设计 ,并探讨了结构参数和操作参数的变化对分级粒径的影响。 相似文献
68.
Hongmin Li 《International Journal of Heat and Mass Transfer》2010,53(4):797-810
This paper presents a thermal fluid analysis on the air cooling of a permanent magnet electric motor with a centrifugal impeller. A numerical model is developed for the heat transfer and fluid flow process. The flow rates of the cooling air are also experimentally measured. The agreement between the numerical model prediction and experimental data is reasonably good. Detailed structures of the cooling flow are presented. Convection heat transfer on the surface of the armature is quantified. Comments on the application of the motor architecture are given. Design modifications are proposed for performance improvements. 相似文献
69.
War War Min Swe Hiroya Morimatsu Hidechito Hayashi Tetsuya Okumura Ippei Oda 《热科学学报(英文版)》2017,26(3):208-213
The flow characteristics of the centrifugal fans with different blade outlet angles are basically discussed on steady and unsteady simulations for a rectangular casing fan. The blade outlet angles of the impellers are 35° and 25° respectively. The unsteady flow behavior in the passage of the impeller 35° is quite different from that in the steady flow behavior. The large flow separation occurs in the steady flow field and unsteady flow field of the impeller 35°, the flow distribution in the circumferential direction varies remarkably and the flow separation on the blade occurs only at the back region of the fan; but the steady flow behavior in the impeller 25° is almost consistent with the unsteady flow behavior, the flow distribution of the circumferential direction doesn't vary much and the flow separation on the blade hardly occurs. When the circumferential variation of the flow in the impeller is large, the steady flow simulation is not coincident to the unsteady flow simulation. 相似文献
70.
Daien Shi Yangyang Liang Archie Eaglesham Zhengming Gao 《Chemical Engineering Research and Design》2014
The bending moment acting on an overhung shaft equipped with an unbalanced impeller, as one of the results of the lateral Fluid-Structure Interactions (FSI) in stirred vessels, was measured using a moment sensor, equipped with digital telemetry. The results show that the imbalance of impeller has a considerable influence on the characteristics of bending moment, such as the mean amplitude and the intensity of amplitude fluctuation. Analysis of the amplitude distribution shows that the distribution is well fitted by a Weibull distribution, which tends to flatten and become more symmetrical about the mean as the imbalance increases. Further analysis of the bending moment power spectral density shows that the speed frequency of the bending moment, whose contribution to the bending moment fluctuation increases with the increasing imbalance, is caused by the imbalance of the stirring structure. These results can be applied to the mechanical design process for the shaft and the stirred vessel supporting it, and the manufacturing control of impeller balance quality. 相似文献