小浪底细砂岩单轴压缩声发射特征研究

采用岩石伺服试验机和声发射仪,对小浪底三叠系细砂岩进行单轴压缩声发射试验。基于试验结果,将试样变形过程划分为压密、弹性、塑性和破坏四个阶段,分析了不同阶段试样声发射幅值、峰值频率、振铃计数和能量的变化特征,在此基础上对比分析了试样声发射ｂ值以及累计振铃计数的演化规律,得出了岩石的破坏时间前兆特征。研究结果表明:压密和弹性阶段试样声发射幅值、振铃计数和能量处于较低水平、峰值频率频带数量依次增多;塑性阶段试样幅值增大、振铃计数与能量上升且整体处于较高水平、峰值频率数值增大且呈现多频带化,临近破坏阶段试样产生大量100ｄＢ的高幅值信号,振铃计数与能量持续急增,峰值频率降低,频带减少;声发射ｂ值的变化规律可以间接反映岩体内部微裂隙萌生、扩展的演化特征。     

On the multi‐input second‐order sliding mode control of nonlinear uncertain systems

This note addresses the multi‐input second‐order sliding mode control design for a class of nonlinear multivariable uncertain dynamics. Among the most important peculiarities of the considered control problem, the considered sliding vector variable has a uniform vector relative degree [2,2, … ,2] with respect to the vector control variable, and only the sign of the sliding vector and of its derivative are available for feedback. Additionally, the symmetric part of the state‐dependent control matrix is supposed to be positive definite. Under some further mild restrictions on the uncertain system's dynamics, a control algorithm that realizes a multi‐input version of the ‘twisting’ second‐order sliding mode control algorithm is suggested. Simple controller tuning conditions are derived by means of a constructive Lyapunov analysis, which demonstrates that the suggested control algorithm guarantees the semiglobal asymptotic convergence to the sliding manifold. Simulation results, which confirm the good performance of the proposed scheme and investigate the actual accuracy obtained under the discrete‐time implementation effects, are given. Copyright © 2011 John Wiley & Sons, Ltd.     

Observer‐based Reliable Control for Discrete Time Systems: An Average Dwell Time Approach

This paper deals with the problem of reliable control for discrete time systems with actuator failures. The actuator is assumed to fail occasionally and can recover over a time interval. During the time of suffering failures, the considered closed‐loop system is assumed unstable. Using an average dwell time method and under the condition that the activation time ratio between the system without actuator failures and the system with actuator failures is not less than a specified constant, an observer‐based feedback controller is developed in terms of linear matrix inequalities such that the resulting closed‐loop system is exponentially stable. An example is included to demonstrate the effectiveness of the proposed approach.     

Perceived control over caregiving outcomes: Implications for child abuse.

We predicted low perceived caregiver control over caregiving failure to be related to (a) coercive or abusive parenting and (b) affective reactions to "difficult" children. On the basis of a multidimensional scaling analysis of the Parent Attribution Test (Study 1), we constructed a scale (PCF) that assessed perceived balance of control over caregiving failure (attributed control to caregivers vs attributed control to children). In Study 2, we found low PCF to predict abusiveness and nonabusive coerciveness among mothers in counseling at a child abuse agency. Additionally, we found low PCF to predict experienced annoyance/irritation among unrelated mothers interacting with children at relatively high risk for abuse (compared with their lower-risk siblings). We interpreted results as demonstrating the potential importance of low perceived control as a moderator of negative affect in response to difficult children. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

基于多模型变权重组合的软件可靠性仿真研究

研究提高软件可靠性预测精度问题,对软件可靠性研究已成为当前软件工程的一个研究热点,传统的单一软件可靠性模型由于使用的技术及提取的信息有限,软件可靠性预测精度不高。为提高软件可靠性预测精度,在建立多种单一软件可靠性预测模型的基础上,提出一种样本点的多模型变权重组合模型。将多种预测技术有效地聚合在一起,取长补短,在样本数据有限的情况下,不仅改善了样本内学习能力也增强了样本外的泛化能力,提高了综合预测精度。仿真验证模型无论在样本内还是样本外都较优于经过模拟退火算法优化的BP神经网络(SA-BP)及经过遗传算法优化的最小二乘支持向量机(GA-LSVM),说明变权重组合模型是一种精度更高的软件可靠性失效数据预测模型,具有较好的应用推广价值。     

浅析计算机网络通讯存在的问题及其改进策略

随着计算机技术取得的长足发展以及计算机的日益普及,计算机网络通讯已成为人们生活及工作中的不可或缺的组成部分。虽然计算机网络通讯极大的方便了人与人之间的沟通,但是仍然存在诸多问题,主要表现在网络通讯技术故障和网络通讯安全方面。网络故障问题主要是硬件连接和软件设置问题,网络通讯安全问题主要体现在非法窃听、恶意篡改、假冒以及对个人信息的非法操作等方面。本文简要剖析了计算机网络通讯当前存在的问题以及针对问题提出了相应解决方案。     

可靠性技术在继电器控制中的应用

本文以可靠性技术,针对继电器在使用时主要失效模式触点失效故障进行分析,从触点材料、控制负载、抑制触点电弧,并对触点在常用环境下不合理使用等问题一并进行了较详细的阐述。     

连铸机扇形段框架和立柱腐蚀失效分析

对连铸机扇形段和框架腐蚀发生的原因进行了分析. 结果表明，在生产现场的特殊环境条件下，腐蚀是各种因素综合作用下缝隙腐蚀加速发展的 结果，冷却水中Cl离子浓度过高是腐蚀加速发展的重要原因, 改善表面保护涂层质量是防治 腐蚀的关键.     

Energy Metabolites as Biomarkers in Ischemic and Dilated Cardiomyopathy

With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi-OMICS approach. Serum metabolites and mRNAseq and epigenetic DNA methylation profiles were analyzed from blood and left ventricular heart biopsy specimens of the same individuals. In total we collected serum from n = 82 patients with Dilated Cardiomyopathy (DCM) and n = 51 controls in the screening stage. We identified several metabolites involved in glycolysis and citric acid cycle to be elevated up to 5.7-fold in DCM (p = 1.7 × 10⁻⁶). Interestingly, cardiac mRNA and epigenetic changes of genes encoding rate-limiting enzymes of these pathways could also be found and validated in our second stage of metabolite assessment in n = 52 DCM, n = 39 ischemic HF and n = 57 controls. In conclusion, we identified a new set of metabolomic biomarkers for HF. We were able to identify underlying biological cascades that potentially represent suitable intervention targets.     

The T Cell Repertoires from Nickel Sensitized Joint Implant Failure Patients

Nickel (Ni²⁺) is one of the most common allergens, affecting around 10–15% of the general population. As the demand for orthopedic implant surgery rises, the number of surgical revisions due to joint implant failure also increases. There is evidence that some patients develop joint failure due to an immune response to a component of the implant, and we have found that Ni²⁺ is an especially important cause. Hence, understanding the mechanisms by which Ni²⁺ allergy induces joint implant failure becomes a critical research question. The structural basis of Ni²⁺ activation of pathogenic T cells is still not clear. The purpose of this study was to characterize Ni²⁺-reactive T cell repertoires derived from the peripheral blood of joint failure patients due to Ni²⁺ sensitization using single-cell sequencing techniques. We stimulated the proliferation of Ni²⁺ -reactive T cells from two implant failure patients in vitro, and sorted them for single-cell VDJ sequencing (10× genomics). We identified 2650 productive V-J spanning pairs. Both TCR α chains and β chains were enriched. TRBV18 usage is the highest in the P7 CD4+ population (18.1%), and TRBV5-1 usage is the highest in the P7 CD8+ population (12.1%). TRBV19 and TRBV20-1 segments are present in a high percentage of both P7 and P9 sequenced T cells. Remarkably, the alpha and beta chain combination of TRAV41-TRBV18 accounts for 13.5% of the CD4+ population of P7 patient. Compared to current Ni specific T cell repertoire studies of contact dermatitis, the Vα and Vβ usages of these joint implant failure patients were different. This could be due to the different availability of self-peptides in these two different tissues. However, TRBV19 (Vβ17) was among frequently used TCR β chains, which are common in previous reports. This implies that some pathogenic T cells could be similar in Ni²⁺ hypersensitivities in skin and joints. The alignment of the TCR CDR3β sequences showed a conserved glutamic acid (Glu) that could potentially interact with Ni²⁺. The study of these Ni²⁺ specific TCRs may shed light on the molecular mechanism of T cell activation by low molecular weight chemical haptens.