Molecular Effects of Low-Intensity Shock Wave Therapy on L6 Dorsal Root Ganglion/Spinal Cord and Blood Oxygenation Level-Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Changes in Capsaicin-Induced Prostatitis Rat Models

Neurogenic inflammation and central sensitization play a role in chronic prostatitis/chronic pelvic pain syndrome. We explore the molecular effects of low-intensity shock wave therapy (Li-ESWT) on central sensitization in a capsaicin-induced prostatitis rat model. Male Sprague–Dawley rats underwent intraprostatic capsaicin (10 mM, 0.1 cm³) injections. After injection, the prostate received Li-ESWT twice, one day apart. The L6 dorsal root ganglion (DRG)/spinal cord was harvested for histology and Western blotting on days 3 and 7. The brain blood oxygenation level-dependent (BOLD) functional images were evaluated using 9.4 T fMRI before the Li-ESWT and one day after. Intraprostatic capsaicin injection induced increased NGF-, BDNF-, and COX-2-positive neurons in the L6 DRG and increased COX-2, NGF, BDNF, receptor Trk-A, and TRPV1 protein expression in the L6 DRG and the dorsal horn of the L6 spinal cord, whose effects were significantly downregulated after Li-ESWT on the prostate. Intraprostatic capsaicin injection increased activity of BOLD fMRI responses in brain regions associated with pain-related responses, such as the caudate putamen, periaqueductal gray, and thalamus, whose BOLD signals were reduced after Li-ESWT. These findings suggest a potential mechanism of Li-ESWT on modulation of peripheral and central sensitization for treating CP/CPPS.     

Serine Hydroxymethyltransferase 1 Is Essential for Primary-Root Growth at Low-Sucrose Conditions

Plant roots are essential organs for absorbing nutrients from the soil or medium. Sucrose functions as a vital carbon source in root development, and sucrose starvation interferes with the redox state of plant cells. However, the mechanism of root growth at sucrose starvation remains unclear. Here, we report that SHMT1 (serine hydroxymethyltransferase 1) plays a crucial role in primary-root growth. SHMT1 mutation caused decreased sugar levels, excessive H₂O₂ accumulation, and severe root-growth arrest at sucrose-free conditions, whereas plants with SHMT1 overexpression had increased sugar and decreased H₂O₂ levels, and longer primary roots. Sucrose supply fully restored root growth of shm1-2, but CO₂ alone could not, and SHMT1 is much more stable in roots than shoots at sucrose conditions, suggesting that SHMT1 accumulation in roots is critical for sucrose accumulation and root growth. Further ROS scavenging by GSH application or ROS synthesis inhibition by apocynin application or RBOHD mutation reduced H₂O₂ levels and partially restored the root-growth arrest phenotype of shm1-2 at low-sucrose conditions, suggesting that SHMT1 modulates root growth via sucrose-mediated ROS accumulation. Our findings demonstrated the role of SHMT1 in primary-root growth by regulating sucrose accumulation and ROS homeostasis in roots.     

Modeling tree root diameter and biomass by ground-penetrating radar

Roots play a key role in ecosystem functioning as they transfer water and nutrients from soil to plants.Traditional methods for measuring roots are labor-intensive and destructive in nature,which limits quantitative and repeatable assessments in longterm research.Ground-penetrating radar(GPR) provides a non-destructive method to measure plant roots.Based on the superiority of GPR with 2 GHz frequency,we developed a new,practical method to estimate root biomass.First,average root matter density was measured ...     

行星齿轮调速器在660MWe超临界空冷机组电动给水泵上的应用

针对给水泵不同驱动方式进行了简单比较,并着重从行星齿轮调速器的安装、调试、运行等方面介绍了行星齿轮调速器在蒲城电厂的使用情况,以期对同行有所帮助。     

CNC齿轮测量中心永磁同步电动机驱动系统设计

对CNC齿轮测量中心的旋转轴永磁同步电动机伺服驱动系统进行了设计优化。分析了id=0电流控制方式下的矢量控制基本原理和转速测量方法,采用了SVPWM控制策略和速度外环的模糊自适应PI控制,与传统的PI控制相比,消除了稳态误差,提高了系统响应速度,减小了超调,使系统具有良好的动、静态特性。通过Matlab/Simulink仿真、硬件实验,结果表明了电机在低速情况下能够稳定运行,验证了所设计的驱动系统的可行性。     

微机保护开平方计算中牛顿迭代法的改进

在分析了查表法以及牛顿迭代法的基础上,对开平方计算的牛顿迭代法进行了改进。改进方法综合了查表法以及牛顿迭代法,运算过程中只需要一次牛顿迭代计算,根据精度要求定量地确定表格大小。通过实例验证了该方法具有运算速度快、精度高、占用内存小的特点,解决了长期以来开平方算法存在耗时长、精度低、存贮数据值范围难以确定的问题。     

基于Ansys Workbench的齿轮副有限元分析

摆线针轮减速器作为重要的机械传动部件具有体积小、重量轻、传动效率高、传动比大、承载能力强和使用寿命长等优点,广泛应用于现代工业诸多领域中.本文针对变桨减速器技术要求,通过典型摆线针轮减速器的传动原理及结构特点分析,建立齿轮、摆线轮等关键零部件的计算模型,并进行静力学有限元分析,其中对代表性的齿轮副进行了有限元模型的建立...     

汽车自动变速器示教板的设计

利用单片机控制发光二极管和光纤来模拟汽车自动变速器的油路、阀体及其故障现象，采用键盘和LED显示器进行人机交互，操作方便简单，软件成功地模拟自动变速器的核心技未——自动换档功能，使学生能够清晰地领会自动变速器的工作原理。     

半集总参数环形电桥设计

本文利用集总电路模型 ,用微带高、低阻抗线实现环形电桥 ,组成 180°功分器 ,用于四线螺旋天线的激励。由于利用半集总参数设计思想 ,功分网络的尺寸减小了一半。     

基于父节点的XML查询优化算法

本文提出了基于父节点的XML查询优化算法,它主要利用关键词的顺序循环查找父节点,把查找出来的父节点集合求交集,所得的父节点交集集合中的元素即为最小子树根节点,最后根据所得出的最小子树根节点得到用户所需的最紧致片段。通过选取经典的INEX数据集算法进行测试。实验结果表明,与传统的XML查询优化算法相比,基于父节点的XML查询优化算法有较高的准确率,更能满足用户需求。