一种5.0~9.3 GHz低功耗宽带低噪声放大器设计

针对Wi-Fi 6、Wi-Fi 6E(5 GHz、6 GHz)的低功耗、宽带宽等无线局域网(WLAN)设备需求,基于65 nm CMOS工艺设计了一款两级低功耗宽带低噪声放大器(LNA)。电路第一级采用结合互补共源电路的共源共栅结构,通过电感峰化技术和负反馈技术的运用,提高输入跨导,降低噪声,并拓展带宽和提高增益平坦度。第二级在共漏极缓冲器基础上引入辅助放大结构、电感峰化技术,实现抵消第一级共源管的噪声并拓展带宽。电路采用提出的前向衬底自偏置技术,以降低电路对电源电压的依赖,整体电路实现两路电流复用,从而有效降低了功耗。仿真结果表明,在5~9.3 GHz频带内LNA的S21为17.8±0.1 dB,S11小于-9 dB、S22小于-11.9 dB,噪声系数小于1.34 dB。在0.8 V电压下整体电路功耗为5.3 mW。     

ILB®, a Low Molecular Weight Dextran Sulphate,Restores Glutamate Homeostasis,Amino Acid Metabolism and Neurocognitive Functions in a Rat Model of Severe Traumatic Brain Injury

In a previous study, we found that administration of ILB^®, a new low molecular weight dextran sulphate, significantly improved mitochondrial functions and energy metabolism, as well as decreased oxidative/nitrosative stress, of brain tissue of rats exposed to severe traumatic brain injury (sTBI), induced by the closed-head weight-drop model of diffused TBI. Using aliquots of deproteinized brain tissue of the same animals of this former study, we here determined the concentrations of 24 amino acids of control rats, untreated sTBI rats (sacrificed at 2 and 7 days post-injury) and sTBI rats receiving a subcutaneous ILB^® administration (at the dose levels of 1, 5 and 15 mg/kg b.w.) 30 min post-impact (sacrificed at 2 and 7 days post-injury). Additionally, in a different set of experiments, new groups of control rats, untreated sTBI rats and ILB^®-treated rats (administered 30 min after sTBI at the dose levels of 1 or 5 mg/kg b.w.) were studied for their neurocognitive functions (anxiety, locomotor capacities, short- and long-term memory) at 7 days after the induction of sTBI. Compared to untreated sTBI animals, ILB^® significantly decreased whole brain glutamate (normalizing the glutamate/glutamine ratio), glycine, serine and γ-aminobutyric acid. Furthermore, ILB^® administration restored arginine metabolism (preventing nitrosative stress), levels of amino acids involved in methylation reactions (methionine, L-cystathionine, S-adenosylhomocysteine), and N-acetylaspartate homeostasis. The macroscopic evidences of the beneficial effects on brain metabolism induced by ILB^® were the relevant improvement in neurocognitive functions of the group of animals treated with ILB^® 5 mg/kg b.w., compared to the marked cognitive decline measured in untreated sTBI animals. These results demonstrate that ILB^® administration 30 min after sTBI prevents glutamate excitotoxicity and normalizes levels of amino acids involved in crucial brain metabolic functions. The ameliorations of amino acid metabolism, mitochondrial functions and energy metabolism in ILB^®-treated rats exposed to sTBI produced significant improvement in neurocognitive functions, reinforcing the concept that ILB^® is a new effective therapeutic tool for the treatment of sTBI, worth being tested in the clinical setting.     

Next-Generation Grade and Survival Expression Biomarkers of Human Gliomas Based on Algorithmically Reconstructed Molecular Pathways

In gliomas, expression of certain marker genes is strongly associated with survival and tumor type and often exceeds histological assessments. Using a human interactome model, we algorithmically reconstructed 7494 new-type molecular pathways that are centered each on an individual protein. Each single-gene expression and gene-centric pathway activation was tested as a survival and tumor grade biomarker in gliomas and their diagnostic subgroups (IDH mutant or wild type, IDH mutant with 1p/19q co-deletion, MGMT promoter methylated or unmethylated), including the three major molecular subtypes of glioblastoma (proneural, mesenchymal, classical). We used three datasets from The Cancer Genome Atlas and the Chinese Glioma Genome Atlas, which in total include 527 glioblastoma and 1097 low grade glioma profiles. We identified 2724 such gene and 2418 pathway survival biomarkers out of total 17,717 genes and 7494 pathways analyzed. We then assessed tumor grade and molecular subtype biomarkers and with the threshold of AUC > 0.7 identified 1322/982 gene biomarkers and 472/537 pathway biomarkers. This suggests roughly two times greater efficacy of the reconstructed pathway approach compared to gene biomarkers. Thus, we conclude that activation levels of algorithmically reconstructed gene-centric pathways are a potent class of new-generation diagnostic and prognostic biomarkers for gliomas.     

PVC低发泡实心板挤出成型技术要点

在PVC低发泡实心板挤出成型中,控制聚合物熔体的流动和发泡是保证产品质量的关键,重点介绍了生产工艺和原理,并分析了生产中的技术要点,提出了解决的办法。     

计及负荷转移需求响应的低碳数据中心光储容量优化配置

为了解决高耗能数据中心低碳化转型问题,提出一种计及负荷转移需求响应的低碳数据中心光储容量配置方法。根据延时特性将数据中心负载分为交互性负载与延时性负载,通过比特-瓦特变换与数据中心电能使用效率得出负载与数据中心能耗之间的关系,以总净现值成本最低为目标函数,考虑清洁能源高渗透率水平、数据流需求响应管控约束,获得数据中心的光储容量配置结果。算例验证了所提方法的有效性。     

2%CrMoNiWV高低压复合转子材料的研究

试验研究了2%CrMoNiWV高低压复合转子材料。试验件在950℃奥氏体化,高压区模拟直径1350mm,模拟喷雾冷速为2.5℃/min,回火温度为660～690℃;低压区模拟直径2500mm,模拟喷水冷速为3℃/min,回火温度为630～660℃。结果表明,综合力学性能达到了目标要求。     

电动汽车微型化发展路径分析

重点分析了我国目前电动汽车和电池技术发展的现状,以及目前电动汽车发展存在的问题,从汽车动力学和电池能量特点提出了电动汽车微型化、低性能发展的思路,并从技术、能耗、成本优化的角度探讨了微型电动汽车发展的可行性。     

电加热方式在SF6开关设备中的应用

由于SF6气体在超低温下产生部分液化,使得SF6开关设备内的SF6气体密度下降,降低了SF6开关设备的开断能力和绝缘水平,无法保证SF6开关设备的可靠运行。为此,本文作者提出了采用电加热装置对SF6开关设备中的SF6气体进行加热,使SF6气体的温度可以始终高于SF6气体液化温度的解决方案。同时,本文对超低温环境下的其他解决方案也进行了分析比较。