厦门广电集团6信道高清转播车改造方案

介绍了厦门广电集团6信道高清转播车改造背景,从实用性、经济性的角度出发,介绍了详细的车体改造方案、系统方案和视音频方案等.     

Development of a Mortality Prediction Model in Hospitalised SARS-CoV-2 Positive Patients Based on Routine Kidney Biomarkers

Acute kidney injury (AKI) is a prevalent complication in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive inpatients, which is linked to an increased mortality rate compared to patients without AKI. Here we analysed the difference in kidney blood biomarkers in SARS-CoV-2 positive patients with non-fatal or fatal outcome, in order to develop a mortality prediction model for hospitalised SARS-CoV-2 positive patients. A retrospective cohort study including data from suspected SARS-CoV-2 positive patients admitted to a large National Health Service (NHS) Foundation Trust hospital in the Yorkshire and Humber regions, United Kingdom, between 1 March 2020 and 30 August 2020. Hospitalised adult patients (aged ≥ 18 years) with at least one confirmed positive RT-PCR test for SARS-CoV-2 and blood tests of kidney biomarkers within 36 h of the RT-PCR test were included. The main outcome measure was 90-day in-hospital mortality in SARS-CoV-2 infected patients. The logistic regression and random forest (RF) models incorporated six predictors including three routine kidney function tests (sodium, urea; creatinine only in RF), along with age, sex, and ethnicity. The mortality prediction performance of the logistic regression model achieved an area under receiver operating characteristic (AUROC) curve of 0.772 in the test dataset (95% CI: 0.694–0.823), while the RF model attained the AUROC of 0.820 in the same test cohort (95% CI: 0.740–0.870). The resulting validated prediction model is the first to focus on kidney biomarkers specifically on in-hospital mortality over a 90-day period.     

A Novel Mouse Model of TGFβ2-Induced Ocular Hypertension Using Lentiviral Gene Delivery

Glaucoma is a multifactorial disease leading to irreversible blindness. Primary open-angle glaucoma (POAG) is the most common form and is associated with the elevation of intraocular pressure (IOP). Reduced aqueous humor (AH) outflow due to trabecular meshwork (TM) dysfunction is responsible for IOP elevation in POAG. Extracellular matrix (ECM) accumulation, actin cytoskeletal reorganization, and stiffening of the TM are associated with increased outflow resistance. Transforming growth factor (TGF) β2, a profibrotic cytokine, is known to play an important role in the development of ocular hypertension (OHT) in POAG. An appropriate mouse model is critical in understanding the underlying molecular mechanism of TGFβ2-induced OHT. To achieve this, TM can be targeted with recombinant viral vectors to express a gene of interest. Lentiviruses (LV) are known for their tropism towards TM with stable transgene expression and low immunogenicity. We, therefore, developed a novel mouse model of IOP elevation using LV gene transfer of active human TGFβ2 in the TM. We developed an LV vector-encoding active hTGFβ2^C226,228S under the control of a cytomegalovirus (CMV) promoter. Adult C57BL/6J mice were injected intravitreally with LV expressing null or hTGFβ2^C226,228S. We observed a significant increase in IOP 3 weeks post-injection compared to control eyes with an average delta change of 3.3 mmHg. IOP stayed elevated up to 7 weeks post-injection, which correlated with a significant drop in the AH outflow facility (40.36%). Increased expression of active TGFβ2 was observed in both AH and anterior segment samples of injected mice. The morphological assessment of the mouse TM region via hematoxylin and eosin (H&E) staining and direct ophthalmoscopy examination revealed no visible signs of inflammation or other ocular abnormalities in the injected eyes. Furthermore, transduction of primary human TM cells with LV_hTGFβ2^C226,228S exhibited alterations in actin cytoskeleton structures, including the formation of F-actin stress fibers and crossed-linked actin networks (CLANs), which are signature arrangements of actin cytoskeleton observed in the stiffer fibrotic-like TM. Our study demonstrated a mouse model of sustained IOP elevation via lentiviral gene delivery of active hTGFβ2^C226,228S that induces TM dysfunction and outflow resistance.     

用户初始服务密码管理方式

本文对用户初始服务密码管理困难的原因进行了深入的分析,提出了将初始服务密码印制在SIM卡涂层下的新型管理方式。     

SOM人工神经网络与阻抗谱方法结合研究涂层的失效过程

    分析了干湿循环条件下有机涂层的电化学阻抗谱特征后选取了阻抗变化率参数作为一维自组织特征映射(self-organizing feature map,SOM)神经网络的训练样本,每个样本对输出层神经元都会产生一定的激发水平,根据该神经网络的特性,输出神经元激发水平的变化趋势便可以反映涂层的降解过程.结合涂层阻抗谱的变化特征,可以把干湿循环条件下涂层的失效过程分为三个阶段,即介质渗入涂层过程,介质到达金属表面诱发金属腐蚀过程和腐蚀扩展涂层剥离过程.     

混合式步进电动机的矢量控制分析

混合式步进电动机与传统的异步、同步电动机相比,由于定子磁势、转子磁钢的非线性分布以及磁饱和等因素的存在而没有简单的线性化数学模型.根据已有数学模型,利用电动机矢量控制原理,在d-q坐标系下推导出混合式步进电动机电磁转矩与电流关系、静态控制与动态控制的数学模型,以及电动机定子电流细分算法,最后通过搭建实验样机验证其控制方法的有效性.     

基于物理结构的电感杂散电容计算方法

介绍了一种计算电感杂散电容的解析方法,以电感的物理结构为基础,将电感绕组分割成彼此相同的基本单元,求出基本单元的电容,即可获得单层、多层电感的电容。实验证明计算的精确度令人满意,可对电感的设计和仿真提供帮助。     

数字音频功放处理芯片设计与实现

介绍了一种数字音频功率放大器数字信号处理的基本原理与实现方法.对整个数字音频功放的数字信号处理器的设计进行了详细介绍,并通过Xilinx FPGA工具进行了验证,利用Synopsys工具进行了完整的电路设计、仿真和版图设计.流片采用Chartered 0.35μm工艺.     

架空输电线路环境荷载响应与设计理论的研究

我国地域广阔, 气候跨区域变化较大, 地形地貌复杂多变, 各地区风、雨以及导线覆冰的分布规律千差万别。由于目前环境荷载因素对输电塔线结构的严重破坏频繁发生, 造成了巨大的经济损失。因此, 有必要建立输电塔线结构环境荷载响应分析理论和进行设计优化, 提高其结构设计的规范水准, 并加强灾害监测控制。这对减轻环境荷载造成的输电塔线结构的灾害具有不可估量的作用。     

引红济石调水工程地质特点及应对措施

陕西引红济石调水工程地质条件非常复杂,施工过程中多次出现断层破碎带塌方、突发性涌水、涌泥等地质难题。结合施工采用的方法、措施分析、研究地质特性和规律,总结施工过程中发生地质灾害的经验教训,认为可以通过加强施工过程控制来有效降低隧洞施工地质风险和灾害发生的可能,从而达到加快工程建设进度,节约工程投资的目的。