A Novel Volume-Stable Collagen Matrix Induces Changes in the Behavior of Primary Human Oral Fibroblasts,Periodontal Ligament,and Endothelial Cells

The aim of the present study was to investigate the influence of a novel volume-stable collagen matrix (vCM) on early wound healing events including cellular migration and adhesion, protein adsorption and release, and the dynamics of the hemostatic system. For this purpose, we utilized transwell migration and crystal violet adhesion assays, ELISAs for quantification of adsorbed and released from the matrix growth factors, and qRT-PCR for quantification of gene expression in cells grown on the matrix. Our results demonstrated that primary human oral fibroblasts, periodontal ligament, and endothelial cells exhibited increased migration toward vCM compared to control cells that migrated in the absence of the matrix. Cellular adhesive properties on vCM were significantly increased compared to controls. Growth factors TGF-β1, PDGF-BB, FGF-2, and GDF-5 were adsorbed on vCM with great efficiency and continuously delivered in the medium after an initial burst release within hours. We observed statistically significant upregulation of genes encoding the antifibrinolytic thrombomodulin, plasminogen activator inhibitor type 1, thrombospondin 1, and thromboplastin, as well as strong downregulation of genes encoding the profibrinolytic tissue plasminogen activator, urokinase-type plasminogen activator, its receptor, and the matrix metalloproteinase 14 in cells grown on vCM. As a general trend, the stimulatory effect of the vCM on the expression of antifibrinolytic genes was synergistically enhanced by TGF-β1, PDGF-BB, or FGF-2, whereas the strong inhibitory effect of the vCM on the expression of profibrinolytic genes was reversed by PDGF-BB, FGF-2, or GDF-5. Taken together, our data strongly support the effect of the novel vCM on fibrin clot stabilization and coagulation/fibrinolysis equilibrium, thus facilitating progression to the next stages of the soft tissue healing process.     

Biomarkers for Cancer Cachexia: A Mini Review

Cancer cachexia is a common condition in many cancer patients, particularly those with advanced disease. Cancer cachexia patients are generally less tolerant to chemotherapies and radiotherapies, largely limiting their treatment options. While the search for treatments of this condition are ongoing, standards for the efficacy of treatments have yet to be developed. Current diagnostic criteria for cancer cachexia are primarily based on loss of body mass and muscle function. However, these criteria are rather limiting, and in time, when weight loss is noticeable, it may be too late for treatment. Consequently, biomarkers for cancer cachexia would be valuable adjuncts to current diagnostic criteria, and for assessing potential treatments. Using high throughput methods such as “omics approaches”, a plethora of potential biomarkers have been identified. This article reviews and summarizes current studies of biomarkers for cancer cachexia.     

影响中小企业球铁质量稳定的因素

分析了影响中小企业球铁生产稳定性的关键因素,指出在一定的原材料条件下,目前中小型企业生产球铁存在的问题是温度偏低,孕育方法不当。     

类金刚石膜的制备及其影响因素

概述了近年来制类金刚石膜的新技术如双射频辉光放电（RF－RF）法，射频－直流辉光放电（RF－DC）法和微波－射频（MW－RF）法等，并且对影响类金刚石膜制备及性能的因素如基体材料，制备类金刚石膜时在膜中添加元素，类金刚石膜与基材之间的中间层等进行了较全面的分析。     

锡磷青铜合金水平连铸工艺参数的优化

铸造锡磷青铜合金组织中存在显微缩松、枝晶偏析和反偏析是冷加工报废的主要原因.通过连铸工艺参数的正交实验,建立了轧制成材率与主要工艺参数之间的神经网络描述,网络模型与遗传算法结合对工艺参数的组合进行了优化,改善了铸坯的组织,提高了轧制带材成材率.     

U形件弯曲影响回弹因素模拟分析

板材在弯曲过程中存在的最突出的问题是弯曲回弹难以精确控制.弯曲卸载后产生的回弹,使弯曲件的形状和尺寸与模具工作部分的形状和尺寸不符.弯曲件的最后形状与整个变形过程有关,模具几何参数、材料性能参数等都会对回弹产生很大影响.在板材弯曲成形智能化控制系统中,准确确定实时识别和预测模型的输入、输出参数是弯曲智能化控制的成功与否以及回弹控制精度高低的关键.本文采用Ls-dyna软件,对U形件弯曲影响回弹的因素进行了分析,得出了影响回弹规律的主要因素.为U形件弯曲智能化控制神经网络参数识别及预测模型输入、输出参数的选择提供依据.     

不同形貌氢氧化镁的化学合成及影响因素

对不同形貌氢氧化镁的化学合成及外部生长环境进行了综述。尤其对影响氢氧化镁结晶性能和形貌起关键作用的因素，如碱性沉淀剂的选择、合成温度的确定、不同镁盐的影响、碱和镁盐的初始浓度及配比、水热处理、反应物的混合方式、晶形控制剂的加入等，进行了详细的阐述。     

整流器故障原因分析

介绍了隔膜碱整流装置发生的整流器故障的经过，并对事故进行了分析，进而提出了类似事故的预防措施。     

近海复杂环境因素对闸墩混凝土裂缝的影响

近海大体积混凝土结构所处的外界环境以及地质条件比较复杂,对于带裂缝水闸结构来说,因所处的地理位置、气候变化以及潮汐升降水位等因素的缘故,水闸闸墩裂缝处于张合状态,这降低了水闸结构的稳定性,甚至会影响水闸结构的寿命。沿海环境温度变化对混凝土裂缝宽度变化的实际监测分析,对于混凝土结构安全耐久性评价具有一定价值,依托典型软土地基永定新河防潮闸工程,利用测缝计对闸墩裂缝宽度变化进行健康监测。主要研究运行期环境因素(以空气温度、水温以及潮汐水位为主)对闸墩裂缝的影响,采用健康安全监测软件,通过对数据的挖掘处理,得出环境温度和水位是影响闸墩水下裂缝宽度变化的敏感性因素的结论,为以后水闸闸墩裂缝的安全维护和裂缝的预防提供思路。