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141.
Bogusz Stephen; Boxer Adam; Busath David D. 《Protein engineering, design & selection : PEDS》1992,5(4):285-293
To examine the feasibility of a ß structure for thepore-lining region of the voltage-gated potassium channel, wehave characterized a family of 12 antiparallel ß-barrels.Each is comprised of four identical pairs of ß-strandsorganized with approximate 4-fold symmetry about a channel axis.The Cand N-termini of the ß-strand pairs are assumedto be at the extracellular end of the channel, and each pairis connected by a hairpin turn at the intracellular end of thechannel. The models differ in the residues located in the hairpinturn and in the orientation of the two strands of each pairin the barrel, i.e. whether the C-terminus of a pair is clockwise(CW) or counterclockwise (CCW) from the N-terminus when thechannel is viewed from outside the cell. Following known structureprecedents and potential energy predictions, the barrel is assumedto be right-twisting in all cases. All models have crowded layersof inward-projecting aromatic sidechains near the center ofthe channel which could regulate channel selectivity. The modelswith an odd number of amino acids in the hairpin turn have theadvantage of predicting that F433 points into the barrel, butthe disadvantage that V438 does not. Of these models, two ofthe models are most consistent with the external tetraethylanunonhim(TEA) block data, and of those, one (T439 CCW 3:5) is most consistentwith the internal TEA block data. 相似文献
142.
143.
G. Cortelazzo G. A. Mian R. Rinaldo 《Multidimensional Systems and Signal Processing》1992,3(2-3):131-160
Spectrum analyzers are ubiquitous in laboratory work concerning one dimensional signals. This is because linear operators are best examined in the frequency domain. Linear operators, such as linear filters, DCT coders, line shufflers, etc., dominate also the video systems scenario. Their frequency domain study is as appropriate and informative as it is in the case of their one-dimensional counterparts. This paper considers the problems associated with the introduction of two well-known spectral estimation techniques, the periodogram and AR estimates, to the context of television signals. The potential for application of spectral estimation to video problems is exemplified by a number of applications related to the fields of enhanced quality television and HDTV. Special attention is paid to the computational aspects, whose effective solution conditions the practical applicability of the proposed spectral estimation techniques.R. Rinaldo is currently at the Department of Electrical and Computer Engineering of the University of California, Berkeley. 相似文献
144.
145.
Jichen Qin 《Chemical engineering science》2006,61(18):6154-6164
A model of continuous melt transesterification of bisphenol-A and diphenyl carbonate in a continuous stirred tank reactor is developed using phase equilibria assumption and the method of molecular weight moments. The model equations can be simplified into a polynomial system that has 17 equations and 17 unknowns. Solution of the polynomial system gives out almost every aspects of the continuous transesterification process. Molecular weight and polydispersity index, end group ratio of hydroxyl to phenyl carbonate, contents of molecular species, and lost diphenyl carbonate fractions are studied in different operation parameters. 相似文献
146.
Marcio Schwaab 《Chemical engineering science》2006,61(17):5791-5806
Model discrimination procedures are useful tools for selection of the best mathematical models to be used to represent a specific chemical process. The present paper presents and discusses a new sequential discrimination procedure, which makes use of model probabilities and concentrates the efforts on models with higher probabilities. Model probabilities are determined based on simple statistical arguments. Four numerical examples illustrate the application of the proposed discrimination procedure. The obtained results indicate that the new procedure is able to discriminate kinetic models with fewer experiments when compared to other procedures and also indicates when model discrimination is not possible and, thus, when the sequential design must be halted. Furthermore, the speed of the proposed discrimination procedure can be controlled by tuning a design parameter which reflects the analyst's mood (confidence) towards the discrimination problem and allows for increase or decrease of the number of experiments required for model discrimination during the sequential procedure. 相似文献
147.
1. Introduction Seismic physical modeling technology is an important method for the research on seismic exploration theory and methods. In seismic physical experiments, the earth, mantle or field site are scaled down to physical models according to the similarity principle, and then the seismic field and its variation are observed in the laboratory for the research work on the theories and methods of the earth structure, earthquake forecasting, energy and mineral resource exploration, and engi… 相似文献
148.
This paper shows that Danckwerts’ law for mean residence time in a vessel with continuous and steady throughflow holds for a stochastic model based on a Markov chain for the particle spatial position, under a set of three very general conditions on the transfer probabilities. These are natural conditions and represent mass balance conditions on the transfer between spatial regions in the process. It is shown that a stochastic model for particle residence time distribution with these three conditions may describe almost any physical flow configuration, and also covers published mathematical RTD models, independent of their mathematical form or the nature of the associated boundary conditions, models for which Danckwert's law has hitherto been shown to be satisfied on a case-by-case basis. Two examples, namely those birth-death Markov chains and fluidized bed models are discussed. 相似文献
149.
150.
中国海上时移地震技术应用的可行性研究 总被引:8,自引:0,他引:8
赵伟 《勘探地球物理进展》2003,26(1):30-34
针对中国海上油田的具体情况,参照国外风险评估方法,进行了一些初步的时移地震可行性研究。总的来说,在中国海上开展时移地震是基本可行的,是必然的发展趋势,但中国海上油田的储层结构和成分比较复杂,因此必须针对不同油田的具体问题,做好各种风险性研究及相应的技术和策略,才能最大限度地降低风险,发挥时移地震技术的效益。 相似文献