新疆天然骨料粉煤灰混凝土抗渗性研究

新疆混凝土工程天然骨料料源丰富,水工混凝土骨料几乎全部采用天然骨料,针对这一特点,结合当地原材料情况,通过实验探讨了影响新疆天然骨料粉煤灰混凝土抗渗性的主要因素,提出了天然骨料粉煤灰混凝土提高抗渗性的最大水胶比和粉煤灰掺量上限值等指标。     

Tumor-Localized Administration of α-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors

Invariant natural killer T (iNKT) cells have the capacity to mount potent anti-tumor reactivity and have therefore become a focus in the development of cell-based immunotherapy. iNKT cells attack tumor cells using multiple mechanisms with a high efficacy; however, their clinical application has been limited because of their low numbers in cancer patients and difficulties in infiltrating solid tumors. In this study, we aimed to overcome these critical limitations by using α-GalCer, a synthetic glycolipid ligand specifically activating iNKT cells, to recruit iNKT to solid tumors. By adoptively transferring human iNKT cells into tumor-bearing humanized NSG mice and administering a single dose of tumor-localized α-GalCer, we demonstrated the rapid recruitment of human iNKT cells into solid tumors in as little as one day and a significantly enhanced tumor killing ability. Using firefly luciferase-labeled iNKT cells, we monitored the tissue biodistribution and pharmacokinetics/pharmacodynamics (PK/PD) of human iNKT cells in tumor-bearing NSG mice. Collectively, these preclinical studies demonstrate the promise of an αGC-driven iNKT cell-based immunotherapy to target solid tumors with higher efficacy and precision.     

110kV全户内城市变电站通风设计的改进

全户内城市变电站对通风设计提出了更高的要求。通过对郑州燕庄110kV全户内变电站主变压器室、10kV高压室等通风设计中,传统的自然通风设计存在的认识上的误区和设计难点的分析,提出了在整个变电站各部分通风设计上的改进,为电气设备提供了安全、有效的运行环境。     

浙江省地闪密度图的绘制方法及其有效性验证

为绘制、研究浙江省地闪密度分布图,选取浙江省雷电定位系统积累的2004～2006年雷电定位系统监测数据为研究样本,提出了利用海量雷电自动监测数据绘制出高分辨率地闪密度图的方法—网格法;依据网格的地闪密度值采用自然分割法将全省区域划分为5级雷区,最终形成了浙江省1km分辨率5级分色地闪密度图。通过分析浙江省地形情况,得出了地闪密度空间分布与地形季风相关性较强的结论;通过分析2004～2006年浙江电网雷击故障点与各级雷区的位置相关性,得出了故障次数与雷区等级正相关的结论,从而验证了地闪密度图的有效性。     

核爆地震波的频特征

对地下核爆炸产生的地震波信号进行联合进频分析,旨在研究核爆炸与天然地震信号在时频平面上的差异,为核监测提供鉴别判别。除疳传统的时域、频域特征统一并推广为时频平面上的矩特征和复杂度特征之外,还提出了利用互模糊函数数图像,时频平面上的时频面积比和累积分布等作为特征,对地震波进行更细致的分析。此外,将时频表示直接进行奇导值分解,用得到的少量奇导值作为一种正交变换特征,以减少特征空间的维数。给出了具体应用     

气田集输系统缓蚀剂对天然气净化厂脱硫溶液发泡的影响研究

含硫气田上下游工艺衔接对气田的安全、优质、高效运行至关重要.针对上游气田批处理过程中缓蚀剂短时大量携入天然气净化厂脱硫系统从而引发的装置发泡、液泛等问题,通过模拟实验和现场工况考察,分析了批处理的缓蚀剂对U DS-2复合脱硫溶液各项性能的影响.研究表明,缓蚀剂是引起脱硫溶液发泡的主要因素,随着缓蚀剂含量的增加,溶剂表面...     

Effective Natural Killer Cell Degranulation Is an Essential Key in COVID-19 Evolution

NK degranulation plays an important role in the cytotoxic activity of innate immunity in the clearance of intracellular infections and is an important factor in the outcome of the disease. This work has studied NK degranulation and innate immunological profiles and functionalities in COVID-19 patients and its association with the severity of the disease. A prospective observational study with 99 COVID-19 patients was conducted. Patients were grouped according to hospital requirements and severity. Innate immune cell subpopulations and functionalities were analyzed. The profile and functionality of innate immune cells differ between healthy controls and severe patients; CD56dim NK cells increased and MAIT cells and NK degranulation rates decreased in the COVID-19 subjects. Higher degranulation rates were observed in the non-severe patients and in the healthy controls compared to the severe patients. Benign forms of the disease had a higher granzymeA/granzymeB ratio than complex forms. In a multivariate analysis, the degranulation capacity resulted in a protective factor against severe forms of the disease (OR: 0.86), whereas the permanent expression of NKG2D in NKT cells was an independent risk factor (OR: 3.81; AUC: 0.84). In conclusion, a prompt and efficient degranulation functionality in the early stages of infection could be used as a tool to identify patients who will have a better evolution.     

天然乳胶产品的鉴定以及风险监控

随着乳胶产品的广泛应用,如何鉴定乳胶中的天然成分以及对毒害化学物质的风险监控成为关注的焦点.采用红外光谱法和水提蛋白质法,利用天然乳胶中所含蛋白质的特征,可准确、快速地鉴定天然乳胶与合成聚异戊二烯乳胶.同时分析了乳胶生产过程中存在的危害化学物质风险及检测限量.     

Research on prevention and cure against heat-harm in constructing mines

With the mine exploitation depth getting deeper and deeper, the mine heat-harm turns into another natural disaster after the five disasters, which are the roof, the gas, the fire, the dust and the flood disaster. Compared with other researches on prevention and cure against the heat-harm, the research on prevention and cure against the heat-harm in constructing mine are less. Referring to the experience of prevention and cure against the heat-harm home and ＇abroad, analyzing the characteristic of cooling in the constructing mine, and based on the ground former freezing equipments and the modified mine temporary cooling equipments, the paper proposed four technical projects. By comparing with the four technical projects, the second project is preponderant both in technology and economy and can solve the heat-harm of the constructing mine, which is proved by the forecast and calculation. The project can be widely applied in de-temperature tasks of high temperature and heat-harm mines during the mine constructing period and in the exploiting preparing phase.