Signal Transduction of Barnacle Egg-Hatching Pheromone: Pharmacological Assays Indicate a Comparatively Simple Mechanism of Eicosanoid Action

Eicosanoids are generally regarded as autocoids that act via G-protein-linked receptors. There are exceptions to this model, however, both in terms of function and mechanism of action. The present paper concerns one such example, an hydroxy fatty acid that acts as a pheromone, not an autocoid, in inducing barnacle egg hatching. Preliminary findings of pharmacological assays on the mechanism of action of this eicosanoid pheromone do not support the involvement of G proteins, Ca²⁺, or protein kinase C in signal transduction. Instead it is concluded, tentatively, that barnacle egg hatching pheromone acts via a comparatively simple pathway involving the second messenger, cyclic AMP.     

小型钟表机床的研究

设计了一台小型钟表机床,通过采用“嵌入式”三维精密工作台和铰链机构、齿形同步带、变频调速器等装置,使得机床整体结构紧凑、尺寸小,而且便于协调控制。同时,该机床也为光机电一体化新型机床的研究提供了一个试验平台。     

KAIST image computing system (KICS): A parallel architecture for real-time multimedia data processing

An efficient parallel architecture is proposed for high-performance multimedia data processing using multiple multimedia video processors (MVP; TMS320C80), which are fully programmable general digital signal processors (DSP). This paper describes several requirements for a multimedia data processing system and the system architecture of an image computing system called the KAIST Image Computing System (KICS). The performance of the KICS is evaluated in terms of its I/O bandwidth and the execution time for some image processing functions. An application of the KICS to the real-time Moving Picture Expert Group 2 (MPEG-2) encoder is introduced. The programmability and the high-speed data-access capability of the KICS are its most important features as a high-performance system for real-time multimedia data processing.     

Terminal Protection of Small Molecule-Linked DNA for Small Molecule–Protein Interaction Assays

Methods for the detection of specific interactions between diverse proteins and various small-molecule ligands are of significant importance in understanding the mechanisms of many critical physiological processes of organisms. The techniques also represent a major avenue to drug screening, molecular diagnostics, and public safety monitoring. Terminal protection assay of small molecule-linked DNA is a demonstrated novel methodology which has exhibited great potential for the development of simple, sensitive, specific and high-throughput methods for the detection of small molecule–protein interactions. Herein, we review the basic principle of terminal protection assay, the development of associated methods, and the signal amplification strategies adopted for performance improving in small molecule–protein interaction assay.     

The Role of Pericytes in Neurovascular Unit Remodeling in Brain Disorders

Neurons are extremely vulnerable cells that tightly rely on the brain’s highly dynamic and complex vascular network that assures an accurate and adequate distribution of nutrients and oxygen. The neurovascular unit (NVU) couples neuronal activity to vascular function, controls brain homeostasis, and maintains an optimal brain microenvironment adequate for neuronal survival by adjusting blood-brain barrier (BBB) parameters based on brain needs. The NVU is a heterogeneous structure constituted by different cell types that includes pericytes. Pericytes are localized at the abluminal side of brain microvessels and contribute to NVU function. Pericytes play essential roles in the development and maturation of the neurovascular system during embryogenesis and stability during adulthood. Initially, pericytes were described as contractile cells involved in controlling neurovascular tone. However, recent reports have shown that pericytes dynamically respond to stress induced by injury upon brain diseases, by chemically and physically communicating with neighboring cells, by their immune properties and by their potential pluripotent nature within the neurovascular niche. As such, in this paper, we would like to review the role of pericytes in NVU remodeling, and their potential as targets for NVU repair strategies and consequently neuroprotection in two pathophysiologically distinct brain disorders: ischemic stroke and Alzheimer’s disease (AD).     

FEATURE EXTRACTION OF VIBRATION SIGNALS BASED ON WAVELET PACKET TRANSFORM

A method is proposed for the analysis of vibration signals from components of rotating machines, based on the wavelet packet transformation (WPT) and the underlying physical concepts of modulation mechanism. The method provides a finer analysis and better time-frequency localization capabilities than any other analysis methods. Both details and approximations are split into finer components and result in better-localized frequency ranges corresponding to each node of a wavelet packet tree. For the purpose of feature extraction, a hard threshold is given and the energy of the coefficients above the threshold is used, as a criterion for the selection of the best vector. The feature extraction of a vibration signal is accomplished by computing the reconstruction signal and its spectrum. When applied to a rolling bear vibration signal feature extraction, the proposed method can lead to be very effective.     

利用电阻法原理测算高岭石的径厚比

高岭石的径厚比,在高岭土的许多应用领域都是一个重要参数,目前尚未有很好的仪器和技术对其进行精确测量。以电阻法为原理对颗粒粒度的测量,反映了电阻的变化与颗粒体积和形貌之间的关系,可以此为基础进行高岭石径厚比计算。通过对以电阻法为工作原理的库尔特仪测试输出数据和图形的详细分析,发现其输出的电脉冲高度反映颗粒的体积,电脉冲宽度反映通过小孔的颗粒长度,并通过与标准球形颗粒脉冲数据进行对比,建立了高岭石径厚比测算公式AR=3/2(n+W-Wn/Wn+1-Wn/L)3通过实例分析,验证了该方法的精确性。     

纳米水流控制器的分子动力学模拟

纳米水流控制器可用于调整生物膜两侧的渗透压,同时在生物大分子以及纳米颗粒的输送方面也有着重要的应用价值。本文中所提出的纳米控制器由石墨烯和两节不同直径的单壁碳纳米管(SWCNT)形成的组合结构,并将由不同管径组合成的碳纳米管作为生物大分子以及纳米颗粒的通道。通过改变非均匀电场的场强实现对纳米尺度下受限空间水流的控制,利用水流的水分子偶极方向的变化驱动碳纳米管内的输送颗粒。本文通过构造垂直于碳纳米管轴径方向的非均匀电场作用于纳米水流控制器,并利用分子动力学模拟的方法对不同斜率梯度电场下的纳米水流控制器进行研究分析。     

视频绝对值变换器BG331小信号应用时的误差

本文讨论了视频绝对值变换器BG331在小信号应用时的误差,指出小信号时存在18mv的附加误差,因此它不适宜作为小信号检波器使用。