基于SPC/SPD的汽车车身装焊质量实时监控与故障诊断

在实现车身装焊质量检验工艺和质量实测数据网络化管理的基础上，采用统计过程控制（SPC）和统计过程诊断（SPD）技术，实现了车身装焊质量的实时与监控和故障原因诊断，提高了质量管理的效率和科学性。     

大功率、大采高电牵引采煤机的研制与应用

随着国家6 m以上厚煤层工作面的开采,国产大功率、大采高电牵引采煤机的研发成为煤炭行业亟待研究的课题。本文介绍了西安煤矿机械有限公司研制的MG900/2210-GWD型采煤机在陕北红柳林煤矿的生产情况,比较了国内外6 m以上煤层大功率采煤机的特点,对采煤机的结构和控制系统进行了改进,并提出了大功率采煤机的发展趋势和研究方向。     

中厚板轧机机架辊问题分析及改进建议

针对中厚板轧机机架辊使用过程中暴露出来的共性问题进行分析研究,并提出技术改进措施。     

铸造旧砂热法再生粉尘-粉煤灰基地质聚合物材料性能研究

以粉煤灰为主要原料,铸造旧砂热法再生粉尘为添加料,水玻璃型碱性激发液为激发剂,制备地质聚合物.采用XRD和SEM对试样微观表征,研究了质量配合比和液固比对铸造旧砂热法再生粉尘-粉煤灰基地质聚合物材料抗压强度的影响.结果表明:材料的物相主要由晶态和非晶态组成;粉煤灰质量配合比的增加和液固比的适量减小,有利于抗压强度的增大.当粉煤灰∶铸造旧砂热法再生粉尘∶水玻璃型碱性激发液=75∶25∶40时,试样28 d的抗压强度最大,达到28MPa.     

Inhibitors of Mitochondrial Human Carbonic Anhydrases VA and VB as a Therapeutic Strategy against Paclitaxel-Induced Neuropathic Pain in Mice

Neuropathy development is a major dose-limiting side effect of anticancer treatments that significantly reduces patient’s quality of life. The inadequate pharmacological approaches for neuropathic pain management warrant the identification of novel therapeutic targets. Mitochondrial dysfunctions that lead to reactive oxygen species (ROS) increase, cytosolic Ca²⁺ imbalance, and lactate acidosis are implicated in neuropathic pain pathogenesis. It has been observed that in these deregulations, a pivotal role is played by the mitochondrial carbonic anhydrases (CA) VA and VB isoforms. Hence, preclinical studies should be conducted to assess the efficacy of two novel selenides bearing benzenesulfonamide moieties, named 5b and 5d, and able to inhibit CA VA and VB against paclitaxel-induced neurotoxicity in mice. Acute treatment with 5b and 5d (30–100 mg/kg, per os – p.o.) determined a dose-dependent and long-lasting anti-hyperalgesic effect in the Cold plate test. Further, repeated daily treatment for 15 days with 100 mg/kg of both compounds (starting the first day of paclitaxel injection) significantly prevented neuropathic pain development without the onset of tolerance to the anti-hyperalgesic effect. In both experiments, acetazolamide (AAZ, 100 mg/kg, p.o.) used as the reference drug was partially active. Moreover, ex vivo analysis demonstrated the efficacy of 5b and 5d repeated treatments in reducing the maladaptive plasticity that occurs to glia cells in the lumbar portion of the spinal cord and in improving mitochondrial functions in the brain and spinal cord that were strongly impaired by paclitaxel-repeated treatment. In this regard, 5b and 5d ameliorated the metabolic activity, as observed by the increase in citrate synthase activity, and preserved an optimal mitochondrial membrane potential (ΔΨ) value, which appeared depolarized in brains from paclitaxel-treated animals. In conclusion, 5b and 5d have therapeutic and protective effects against paclitaxel-induced neuropathy without tolerance development. Moreover, 5b and 5d reduced glial cell activation and mitochondrial dysfunction in the central nervous system, being a promising candidate for the management of neuropathic pain and neurotoxicity evoked by chemotherapeutic drugs.     

信息环境下高校图书馆信息素质教育职能的提升

通过中外信息素质教育对比,阐述了信息环境下提升高校图书馆信息素质教育职能的必要性,提出了成立信息素质教研室、开拓信息服务超市等具体的措施。     

浅谈天然气气藏无机成因

油气有机成因说的发展日趋成熟,无机成因说则几经挫折。随着地质勘探的不断深入和资料的不断积累,认为虽然有机成因油气资源占据着主导地位,但也不能排除存在着无机成因的油气资源。通过研究烷烃气和二氧化碳的死亡温度,说明在高温的地球深处有无机成因气存在。对无机成因气形成的构造地质条件、物理化学条件和成藏条件进行了分析,侧重讨论不同于有机成因气的常规控制条件的特殊方面,并对无机成因气和有机成因气的成藏条件作了比较分析。     

徐坤学人小说论

以学者和女性的双重身份出发,探讨了徐坤的小说在内容、女性视角、语言风格三个方面区别于其他学人小说的特征。     

从时间维度出发的建筑设计

本文讨论了从时间维度出发进行建筑设计的方法及可能性。主要分析了建筑师、感受主体、感受客体之间的相互关系,提出了从时间维度出发进行建筑设计的几个主要步骤,并举具体实例分析不同情况下,考察时间段和考察要素的不同。为建筑创作提供了一些新的思路。