连铸轻压下技术的机理比较

轻压下技术对改善连铸坯中心偏析有显著的效果，在生产中得到了广泛的应用。为此分析了两种机械压下技术改善中心偏析的机理，比较两者改善中心偏析的效果，并进一步讨论了轻压下技术在工业应用中要注意的问题。     

高原河流生态保护模式初探——以地震灾后重建“两河”生态保护为例

与平原河流相比,高原河流具有独特的水动力、地质地貌和生态特点。以青海省玉树州结古镇2010年遭受的地震为背景,在对现状进行充分调研、分析的基础上,查找存在的问题,立足治理需求,在满足防洪排涝要求的基础上,提出生态环境改善和景观水文化重建模式,为结古镇未来的经济社会发展和人民生活提供安全、舒适的水利支撑。将生态水力学与工程水力学相结合,根据扎西科河和巴塘河的特点(水文、地理和气候特征),以当地鱼类为保护目标,采用近自然修复技术,确定了河道的平面形态和断面型式。结合《结古镇地震灾后重建总体规划》,对滨水空间进行了划分,并根据有关规范对三线进行了界定。同时对河道的管理提出了一些建设性意见,可对扎西科河和巴塘河的可持续发展提供参考,对流域的治理和保护工作提供借鉴。     

基于“嵩山”超级计算机系统的大规模管网仿真

供水管网仿真广泛应用于城市供水输配调度,是城市供水管网监测与维护的重要技术手段。由于在面向城市级的大规模管网中产生了海量的计算数据,因此在一般计算平台上无法满足管网仿真计算的算力需求。为提升城市级供水管网仿真的计算效率,提出一种有效的并行化方案。基于“嵩山”超级计算机系统采用中央处理器+数据缓存单元（CPU+DCU）架构,利用其在密集数据计算方面的优势,对“嵩山”超级计算机进行供水管网仿真。参照可移植性异构计算接口（HIP）异构编程模型,在“嵩山”超级计算机上实现供水管网仿真的异构计算,并结合管道数据分割方案,使用消息传递接口开启多进程以实现DCU加速数据通信传递。通过重定义数据类型解决计算过程中结构体传输问题,实现单节点内多DCU的大规模密集计算。在不同计算平台和多种计算策略仿真上的对比结果表明,与传统x86平台相比,该优化方案在小规模数据与大规模数据上的加速比分别达到5.269、10.760,与采用计算统一设备架构异构编程模型的传统GPU异构平台相比,计算性能有明显提高。     

Formulation and development of ophthalmic in situ gel for the treatment ocular inflammation and infection using application of quality by design concept

Context: The conventional liquid ophthalmic delivery systems exhibit short pre-corneal residence time and the relative impermeability to the cornea which leads to poor ocular bioavailability.

Objective: The aim of this study was to apply quality by design (QbD) for development of dexamethasone sodium phosphate (DSP) and tobramycin sulfate (TS)-loaded thermoresponsive ophthalmic in situ gel containing Poloxamer 407 and hydroxyl propyl methyl cellulose (HPMC) K4M for prolonging the pre-corneal residence time, ocular bioavability and decreases the frequency of administration of dosage form. The material attributes and the critical quality attributes (CQA) of the in situ gel were identified. Central composite design (CCD) was adopted to optimize the formulation.

Materials and methods: The ophthalmic in situ forming gels were prepared by cold method. Materials attributes were the amount of Poloxamer 407 and HPMC and CQA identified were Gel strength, mucoadhesive index, gelation temperature and % of drug release of both drug.

Results and discussion: Optimized batch (F*) containing 16.75% poloxamer 407 and 0.54% HPMC K4M were exhibited all results in acceptable limits. Compared with the marketed formulation, optimized in situ gel showed delayed T_max, improved C_max and AUC in rabbit aqueous humor, suggesting the sustained drug release and better corneal penetration and absorption.

Conclusion: According to the study, it could be concluded that DSP and TS would be successfully formulated as in situ gelling mucoadhesive system for the treatment of steroid responsive eye infections with the properties of sustained drug release, prolonged ocular retention and improved corneal penetration.     

Analysis and evaluation of a general camera model

A versatile General Camera Model, GCM, has been developed, and is described in detail. The model is general in the sense that it can capture both fisheye and conventional as well as catadioptric cameras in a unified framework. The camera model includes efficient handling of non-central cameras as well as compensations for decentring distortion. A novel way of analysing radial distortion functions of camera models leads to a straightforward improvement of conventional models with respect to generality, accuracy and simplicity. Different camera models are experimentally compared for two cameras with conventional and fisheye lenses, and the results show that the overall performance is favourable for the GCM.     

基于CAS集群的单点失效问题解决方案

单点登录(SSO)可以消除多个应用服务系统之间的重复认证过程,但会加重认证负载,引起单点失效的风险,导致服务中断。针对上述问题,提出具有集群功能的单点登录系统,将用户登录请求分发到不同的单点登录服务器,解决单个单点登录服务器负担过重的问题,增强系统运行的稳定性。     

基于多Agent的医疗信任模型的模拟

结合直接交互信任评价和第三方信誉推荐,提出了一种基于多Agent技术的医疗信任模拟模型。使用置信因子来综合直接交互信任值和第三方信誉推荐值;避免了患者直接交互的盲目性和巨额计算,完善了对医生自我推荐的辨别能力。实验采用Swarm仿真平台模拟医疗信任模型的交互过程,结果表明该模型在确定信任关系中相对IT模型要快,比第三方信誉推荐模型相对要可靠。     

A high-order non-oscillatory central scheme with non-staggered grids for hyperbolic conservation laws

In this work, we present a scheme which is based on non-staggered grids. This scheme is a new family of non-staggered central schemes for hyperbolic conservation laws. Motivation of this work is a staggered central scheme recently introduced by A.A.I. Peer et al. [A new fourth-order non-oscillatory central scheme for hyperbolic conservation laws, Appl. Numer. Math. 58 (2008) 674–688]. The most important properties of the technique developed in the current paper are simplicity, high-resolution and avoiding the use of staggered grids and hence is simpler to implement in frameworks which involve complex geometries and boundary conditions. Numerical implementation of the new scheme is carried out on the scalar conservation laws with linear, non-linear flux and systems of hyperbolic conservation laws. The numerical results confirm the expected accuracy and high-resolution properties of the scheme.     

Irrigation infrastructure development in the Limarí Basin in Central Chile: implications for adaptation to climate variability and climate change

One option to deal with climate variability in agriculture is to build irrigation infrastructure, although this may lead to the overdevelopment of water resources, leading to ‘basin closure’. The Limarí Basin, in central north Chile, has relied on irrigation infrastructure over the last 30 years to increase water supply reliability and extend irrigated acreage, especially for permanent crops. This situation has reduced adaptation opportunities in the basin, which is currently experiencing a severe drought that, according to climate change projections, is expected to persist in the future, with important consequences for the sustainability of agriculture production.     

浅谈新疆某水库闸门集中控制系统

新疆某水库泄洪闸门集控系统是以美国Wonderware公司的Intouch 10.1系统监控软件为开发平台所建立的一套集远程监控和远程操作为一体的闸门控制系统。该系统上位机通过局域网与各闸门控制系统的PLC进行通讯,包括上送各种信息和接受控制命令,通讯采用标准以太网,支持TCP/IP协议,系统建立于2011年6月,经过1年多的操作运行,情况良好。