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41.
42.
提高Cr12MoV钢冷作模具寿命的措施 总被引:3,自引:0,他引:3
从原材料改锻、预备热处理、淬火及回火、深冷处理、表面强化处理等方面分析介绍了提高Cr12MoV钢冷作模具寿命的一些方法和措施 ,并通过实例表明 ,采用这些方法和措施可较大幅度地提高模具寿命 相似文献
43.
Myeongjoo Son Seyeon Oh Junwon Choi Ji Tae Jang Kuk Hui Son Kyunghee Byun 《International journal of molecular sciences》2021,22(8)
Hypertension induces renal fibrosis or tubular interstitial fibrosis, which eventually results in end-stage renal disease. Epithelial-to-mesenchymal transition (EMT) is one of the underlying mechanisms of renal fibrosis. Though previous studies showed that Ecklonia cava extracts (ECE) and dieckol (DK) had inhibitory action on angiotensin (Ang) I-converting enzyme, which converts Ang I to Ang II. It is known that Ang II is involved in renal fibrosis; however, it was not evaluated whether ECE or DK attenuated hypertensive nephropathy by decreasing EMT. In this study, the effect of ECE and DK on decreasing Ang II and its down signal pathway of angiotensin type 1 receptor (AT1R)/TGFβ/SMAD, which is related with the EMT and restoring renal function in spontaneously hypertensive rats (SHRs), was investigated. Either ECE or DK significantly decreased the serum level of Ang II in the SHRs. Moreover, the renal expression of AT1R/TGFβ/SMAD was decreased by the administration of either ECE or DK. The mesenchymal cell markers in the kidney of SHRs was significantly decreased by ECE or DK. The fibrotic tissue of the kidney of SHRs was also significantly decreased by ECE or DK. The ratio of urine albumin/creatinine of SHRs was significantly decreased by ECE or DK. Overall, the results of this study indicate that ECE and DK decreased the serum levels of Ang II and expression of AT1R/TGFβ/SMAD, and then decreased the EMT and renal fibrosis in SHRs. Furthermore, the decrease in EMT and renal fibrosis could lead to the restoration of renal function. It seems that ECE or DK could be beneficial for decreasing hypertensive nephropathy by decreasing EMT and renal fibrosis. 相似文献
44.
Gaofeng Yuan Mengmeng Xu Meijuan Tan Jian Dong Xiaoe Chen 《European Journal of Lipid Science and Technology》2021,123(1):2000224
The study aims to investigate the effect of combined supplementation with docosahexaenoic acid (C22:6 n-3, DHA) and vitamin E (VE) on the oxidative stress and liver triglycerides (TG) accumulation induced by high-fat diet (HFD) in mice. C57BL/6J mice are fed either a control diet or an HFD for 8 weeks. Animals are supplemented with DHA, VE, or DHA + VE, respectively. Supplementation with DHA alone shows significant improvement in oxidative stress and hepatic steatosis in mice. Supplementation with DHA significantly reduces the liver TG and total cholesterol contents, and the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, compared with the HFD. Supplementation with DHA also significantly decreases the mRNA expression level of sterol regulatory element-binding protein 1C. However, supplementation with VE alone does not show improvement in oxidative stress and hepatic steatosis. DHA + VE supply obtains a superior effect in alleviation of hepatic steatosis than DHA supplementation alone in mice fed by HFD. The efficacy of DHA potentiated by VE can be due to that VE enhances the effect of DHA in decrease of ALT and AST levels and increase of antioxidant enzyme activity and glutathione level in mice fed by HFD. Practical Applications: Supplementation with DHA significantly improves the oxidative stress and hepatic steatosis induced by HFD in mice. The efficacy of DHA in the alleviation of hepatic steatosis induced by HFD is potentiated by VE. These findings may provide a rational basis for the use of DHA and VE co-supplementation in patients with liver steatosis. 相似文献
45.
1,12-bis(1,2,4-triazolyl)dodecane (dTC12) is an excellent corrosion inhibitor for carbon steel in deaerated 1 M HCl solution. In this work electrochemical and analytical techniques were used to study the inhibition of corrosion on carbon steel in acidic medium. The carbon steel corrosion inhibition of dTC12 was attributed to the synergistic effect between chloride anion and quaternary ammonium ion. The protective efficiency of the film was higher than 90%, indicating that corrosion of carbon steel in 1 M HCl is reduced by dTC12.The effect of dissolved oxygen on the inhibition efficiency was also investigated. The results show that the inhibition efficiency increases in early stage and decreases for a long immersion time. 相似文献
46.
液压机本体柔性化设计相关技术的研究 总被引:3,自引:0,他引:3
针对液压机本体设计特点,在液压机本体CAD应用系统的开发中,引入了柔性化设计的概念,以Pro/E为建模后台、VB6.0为操作语言,研究了柔性化设计的相关技术,并提出了相关解决方案,并为以:Pro/E为后台的应用系统的开发提供了一种可行方案。 相似文献
47.
基于Pro/E的三维参数化标准件库的建立 总被引:1,自引:0,他引:1
介绍了基于Pro/E特征造型的三维参数化标准件库的建立技术及使用方法.利用特征造型、参数化设计创建通用模型,通过设置参数关系式及利用族表集合共同的可变尺寸,生成一系列的零件模型形成库文件,不需要逐一创建单个模型,能够大幅度提高设计速度和节约磁盘空间. 相似文献
48.
将机械合金化(MA)Al-12Ti-6Nb合金在550℃下空气中长时间暴露后,用光学显微镜和电子探针对其组织结构变化进行了观察与分析,测定了维氏硬度。结果表明,MAAl-12Ti-6Nb表现出良好的热稳定性,在550℃下暴露200h后,Al3Ti中的亚稳的α-Ti核才全部转变为Al3Ti,Al3Ti颗粒随之粗化,饼状的Al3Ti变成椭球体;Al3Ti颗粒的粗化是通过Ti,Al原子扩散所控制的α-T 相似文献
49.
ADC12铝合金在水蒸汽中的腐蚀行为 总被引:1,自引:0,他引:1
铸态和固溶化处理的ADC12铝合金在90℃水蒸汽中的腐蚀试验表明:铸态铝合金基体腐蚀是以Al-Cu为基的第二相化合物,而以Al-Fe为基的化合物不会引起基体腐蚀;经固溶化处理的铝合金基体腐蚀是由Al-Fe为基的化合物引起的,并且是以含Cu的Al-Fe化合物周围优先被腐蚀。 相似文献
50.