一种卫生陶瓷高压成形泥浆的研制

笔者通过使用细粉料,改变软质料与硬质料的比例,以提高吃浆速度,提升生产效率;引入矿化剂硅灰石原料,优化配方的化学组成,降低产品的变形;并引入新型增强剂,达到提高干燥强度,降低半成品的破损率的目的。     

中材电瓷绝缘子水泥胶合剂实验研究

本课题研究依托中材江西电瓷电气有限公司的智能化生产线建设项目，主要从水泥品种、缓凝剂种类、矿物掺合料用量等方面研究提高水泥胶合剂早期强度的方案。试验表明通过掺加缓凝剂和矿渣后，硫铝酸盐水泥更优于早强型硅酸盐水泥的综合性能；同时通过生产工艺的改进，使得胶合剂各组分计量准确，利用公司窑尾废气温度来提高养护室温度以提高胶合剂的早期强度，加快脱模速度，即可满足智能化生产线批量生产要求。     

小角法在大坝视准线观测中的应用

从观测思路、测点偏离值与位移量计算公式推导、精度分析等几方面阐述了小角法在长度不同的视准线观测中的灵活运用。     

Building Community

Without the legal and economic strictures of permanent construction, pop-up architecture offers a unique opportunity for architects to build small-scale structures that enable community participation and social engagement. What, though, are the political manifestations for instigating this type of public participation through lightweight architectural programming? Andrea Kahn , Adjunct Professor of Urban Planning at Columbia University Graduate School of Architecture, Planning and Preservation (GSAPP), examines this phenomenon by profiling three projects located in the public realm by Jonathan Kirschenfeld and CDR Studio in New York, and Vallo Sadovsky Architects in Bratislava.     

多体系统动力学的常用积分器算法

本文将以单步法中的广义 α族积分器和多步法中的BDF族积分器为主要讨论对象,详细介绍大型多体系统动力学软件中常见类型的积分器的算法细节.每族积分器都给出了不止一套计算公式,而且其对应求解微分代数方程组(DAE)的index可以为1、2或者3.除此以外,本文还着重介绍了微分代数方程组的误差估计、变阶变步长策略等关键技术;并讨论了大型DAE问题求解过程中的初始条件分析、Jacobian矩阵复用等重要环节的算法实现;对于BDF积分器族,文中还详细描述了高阶格式的非绝对稳定性、速度变量的误差估计等瓶颈问题的解决方案.全文以多体系统动力学软件的积分器程序实现为目标,强调在满足给定精度的条件下,如何提高计算效率和保证仿真运行的鲁棒性.另外,本文也简要介绍了在某些应用场合中有很大潜力的显式积分器族.通过分析和比较,文中还将指出各种算法的优缺点以及可能的改进方向,希望能够为研究人员和程序开发者提供一定的参考.由于篇幅限制,本文只列出了几个标准的算例比较,作为文中内容的补充;并给出了几种积分器性能比较的一般性结论.文中几乎所有方法都经由作者程序实现、测试和比较,并且相关算法的实现细节也都已尽量列出,可以很容易地编程实现并应用到实际问题的求解中去.     

Bushen Yizhi Formula regulates the IRE1α pathway to alleviate endoplasmic reticulum stress in an Alzheimer’s disease rat model

Background: While the Bushen Yizhi Formula can treat Alzheimer’s disease (AD), the yet to be ascertained specific mechanism of action was explored in this work. Methods: Different concentrations of the Bushen Yizhi Formula and amyloid-beta peptide (Aβ) were used to treat rat pheochromocytoma cells (P12) and human neuroblastoma cells (SH-SY5Y). Cell morphological changes were observed to determine the in vitro cell damage. Cell Counting Kit (CCK)-8 assay and flow cytometry were employed to identify cell viability and apoptosis/cell cycle, respectively. Western blotting and immunohistochemistry were employed to measure the expressions of endoplasmic reticulum stress (ERS)-related proteins (GRP78 and CHOP), p-IRE1α, IRE1α, ASK1, p-JNK, JNK, Bax, Bcl-2, XBP-1, and Bim. Fura 2-acetoxymethyl ester (Fura-2/AM) was used to determine the intracellular calcium (Ca²⁺) concentration. Also, an AD model was constructed by injecting Aβ into the CA1 area of the hippocampus in Sprague Dawley rats. AD model rats were gavaged with different concentrations of Bushen Yizhi Formula for 14 consecutive days. The Morris water maze experiment was conducted to test the learning and memory of rats. Hematoxylin & Eosin (H&E) and Terminal-deoxynucleotidyl Transferase (TdT)-mediated dUTP Nick-End Labeling (TUNEL) staining were done to determine histopathological changes in the brain. Results: Bushen Yizhi Formula relieved the Aβ-induced effects including cell injury, decreased viability, increased apoptosis, G0/G1 phase cell cycle arrest, upregulation of GRP78, CHOP, p-IRE1α, p-JNK, Bax, XBP-1 and Bim, as well as down-regulation of Bcl-2. These results were also seen with IRE1α silencing. While Aβ suppressed the learning and memory abilities of rats, the Bushen Yizhi Formula alleviated these effects of Aβ. Brain nerve cell injury induced by Aβ could also be treated with Bushen Yizhi Formula. Conclusion: Bushen Yizhi Formula could influence ERS through the IRE1α signaling pathway to achieve its therapeutic effects on AD.     

特殊医学用途配方食品产品配方研发注册常见问题及解决建议研究

目的 通过探讨分析特殊医学用途配方食品产品配方研发注册存在的问题及解决建议，为该类产品研发、注册管理、临床使用等提供参考。方法 从产品注册申请和技术审评的角度，对特殊医学用途配方食品的含义和组成要求、研发设计原则及重点内容、注册申请材料关注重点等进行分析总结。结果 特殊医学用途配方食品的产品配方设计应以标准和法规为基础，整体观是产品配方设计的重点，临床使用是产品配方设计的主导，同时应关注注册申请材料的完整性和统一性。结论 产品配方设计是特殊医学用途配方食品研发的重中之重，应关注其科学性、合理性和临床适用性，相关部门也应进一步完善相关标准法规。