省级电力客服中心供电服务业务支撑作用的思考

通过对95598全业务集中后,省级电力公司客户服务中心业务职能在营销业务中的角色转换和支撑作用方面面临的一些问题的分析,提出应深化信息系统应用、优化指标管控方式、强化信息报送管理、加强内质外形建设等几点建议,以期为更好发挥省级客服中心对供电服务业务的支撑作用提供一些有益的参考。     

On the Certification of Bonded Repairs to Primary Composite Aircraft Components

Airworthiness certification is required when bonded repairs are made to primary composite structure in situations where damage has reduced or has the potential to reduce residual strength to below the design ultimate strength. Generally, certification of bonded primary structure poses many difficulties. As most repairs are one-off events meeting these certification requirements is especially challenging since demonstration by testing will generally not be possible or cost-effective. This paper discusses options for addressing the two key issues relating to certification: (a) how to validate initial and enduring bond strength of adhesive bonds, mainly given the inability of conventional non-destructive inspection to provide this assurance and (b) how to develop acceptable generic design allowables for bonded repairs which represent actual failure modes – especially for cyclic loading, since validation by testing of simulated repairs will generally be infeasible. It is concluded that proof testing of bonded repair coupons is a promising approach for validating bond strength and fatigue testing of representative bond joint specimen can provide generic allowables for patch design. For hidden structure or very high value repairs structural health monitoring of repairs based on a strain-transfer approach offers considerable promise.     

计算机硬件设备常见故障原理及维修

计算机的应用在当前已极为普及,而在应用过程中计算机故障也极为常见,其中硬件设备方面出现的问题尤为突出。笔者就此分析了计算机硬件设备的常见故障原理,探讨了其维修策略,希望有所指导和帮助。     

滑坡落石灾害自动监测方案的探讨

以西部某客运专线的隧道施工监测为工程背景,探讨了铁路隧道所通过山体的稳定性自动监测问题,提出了一系列监测实施方案,可以为类似工程提供参考。     

全再生快速修补混凝土的制备及性能

根据修补区混凝土可开放交通的要求,优选出全再生快速修补混凝土最优配合比,并与常用的再生粗骨料快速修补混凝土进行比较.结果表明,全再生快速修补混凝土的抗压强度和粘结强度较易满足要求;其最优化配合比参数为:胶凝材料总量为500 kg/m3,再生细骨料在细骨料中掺量为30％,而其砂率为35％;其干燥收缩略大于常用的再生粗骨料快速修补混凝土,但显著提高了其抗氯离子渗透性能.     

古建筑保护中的整旧如旧与整旧如新

以古建筑保护的方向为出发点,对整旧如旧与整旧如新两种古建筑的修缮保护观点进行了论述,指出整旧如新的做法在古建筑的保护中存在着很大的弊端,但整旧如旧如果处理不当同样会对古建筑产生保护性伤害,在古建筑保护修缮过程中应针对不同问题区别对待。     

残余应力测试在转向架构架返修中的应用

采用X射线法对转向架构架焊接部件返修位置与未进行返修位置进行残余应力状态的测试,分析比较两处位置残余应力应力状态,从残余应力的角度评价返修后产品使用的可行性。     

某小型航空发动机排气锥裂纹焊接修复

某小型航空发动机排气锥服役中产生大量裂纹,通过观察裂纹断口宏观形貌、微观组织及能谱分析,判断裂纹为应力腐蚀裂纹。焊前采用固溶处理恢复母材为奥氏体组织,消除晶间贫铬,采用脉冲钨极氩弧焊修复裂纹,焊后对焊缝进行喷丸强化处理,成功修复排气锥裂纹。     

Theranostic Interpolation of Genomic Instability in Breast Cancer

Breast cancer is a diverse disease caused by mutations in multiple genes accompanying epigenetic aberrations of hazardous genes and protein pathways, which distress tumor-suppressor genes and the expression of oncogenes. Alteration in any of the several physiological mechanisms such as cell cycle checkpoints, DNA repair machinery, mitotic checkpoints, and telomere maintenance results in genomic instability. Theranostic has the potential to foretell and estimate therapy response, contributing a valuable opportunity to modify the ongoing treatments and has developed new treatment strategies in a personalized manner. “Omics” technologies play a key role while studying genomic instability in breast cancer, and broadly include various aspects of proteomics, genomics, metabolomics, and tumor grading. Certain computational techniques have been designed to facilitate the early diagnosis of cancer and predict disease-specific therapies, which can produce many effective results. Several diverse tools are used to investigate genomic instability and underlying mechanisms. The current review aimed to explore the genomic landscape, tumor heterogeneity, and possible mechanisms of genomic instability involved in initiating breast cancer. We also discuss the implications of computational biology regarding mutational and pathway analyses, identification of prognostic markers, and the development of strategies for precision medicine. We also review different technologies required for the investigation of genomic instability in breast cancer cells, including recent therapeutic and preventive advances in breast cancer.     

The Barley Chloroplast Mutator (cpm) Mutant: All Roads Lead to the Msh1 Gene

The barley chloroplast mutator (cpm) is a nuclear gene mutant that induces a wide spectrum of cytoplasmically inherited chlorophyll deficiencies. Plastome instability of cpm seedlings was determined by identification of a particular landscape of polymorphisms that suggests failures in a plastome mismatch repair (MMR) protein. In Arabidopsis, MSH genes encode proteins that are in charge of mismatch repair and have anti-recombination activity. In this work, barley homologs of these genes were identified, and their sequences were analyzed in control and cpm mutant seedlings. A substitution, leading to a premature stop codon and a truncated MSH1 protein, was identified in the Msh1 gene of cpm plants. The relationship between this mutation and the presence of chlorophyll deficiencies was established in progenies from crosses and backcrosses. These results strongly suggest that the mutation identified in the Msh1 gene of the cpm mutant is responsible for the observed plastome instabilities. Interestingly, comparison of mutant phenotypes and molecular changes induced by the barley cpm mutant with those of Arabidopsis MSH1 mutants revealed marked differences.