钛合金热加工保护涂层自剥离性研讨

钛合金热保护涂层，主要功能是防止钛合金在加热或热加工过程中的严重氧化．但是在热加工结束后，涂层的去除十分困难，如果能够在不影响保护效果的前题下，使涂层在热加工结束后自动剥离．这将给生产带来极大的方便．讨论由玻璃和粘土组成的不同涂层配方，经过试验和计算，找出构成涂层的二个组份—玻璃及粘土，在涂层使用过程中的不同作用．认为，在加热及热加工阶段，玻璃发挥主要作用，而在加工后的冷却剥离阶段，粘土起主要作用     

北京建筑内外装饰涂层脱落机理及对策

涂层脱落是严重影响北京形象的建筑工程质量通病。但迄未获得很好地解决。作者通过对所建立的13个对照组的调研，分析了该现象的成因及机理，并在此基础上提出了一些治理这一现象的建议。     

裘皮服装新概念与新趋势之论

通过对裘皮服装兴衰史的演变,现代主义理念对现代人生活观念与生活环境的影响,世界皮草市场的新动向,裘皮设计与新工艺技术的进步等几个方面的论述,提出裘皮服装大众化、平民化的新概念,预示了兔羊皮草成衣将替代以貂、狐为代表的高级皮草时装,成为现代皮草设计和皮草市场主流的新趋势.     

Delayed release film coating applications on oral solid dosage forms of proton pump inhibitors: case studies

Background: Formulation of proton pump inhibitors (PPIs) into oral solid dosage forms is challenging because the drug molecules are acid-labile. The aim of this study is to evaluate different formulation strategies (monolithic and multiparticulates) for three PPI drugs, that is, rabeprazole sodium, lansoprazole, and esomeprazole magnesium, using delayed release film coating applications. Method: The core tablets of rabeprazole sodium were prepared using organic wet granulation method. Multiparticulates of lansoprazole and esomeprazole magnesium were prepared through drug layering of sugar spheres, using powder layering and suspension layering methods, respectively. Tablets and drug-layered multiparticulates were seal-coated, followed by delayed release film coating application, using Acryl-EZE®, aqueous acrylic enteric system. Multiparticulates were then filled into capsules. The final dosage forms were evaluated for physical properties, as well as in vitro dissolution testing in both compendial acid phase, 0.1N HCl (pH 1.2), and intermediate pH, acetate buffer (pH 4.5), followed by phosphate buffer, pH 6.8. The stability of the delayed release dosage forms was evaluated upon storage in accelerated conditions [40°C/75% relative humidity] for 3 months. Results: All dosage forms demonstrated excellent enteric protection in the acid phase, followed by rapid release in their respective buffer media. Moreover, the delayed release dosage forms remained stable under accelerated stability conditions for 3 months. Conclusions: Results showed that Acryl-EZE enteric coating systems provide excellent performance in both media (0.1N HCl and acetate buffer pH 4.5) for monolithic and multiparticulate dosage forms.     

红外热像法检测外墙饰面空鼓缺陷时结果的可靠性

本文研究热像仪设备、检测人员、天气环境、拍摄距离、拍摄倾角、缺陷程度等主要参数的改变,对检测质量可靠性的影响.利用实例采集的检测数据,进行检测结果比对,分析红外热像法检测外墙饰面空鼓缺陷时质量的可靠性.根据统计结果归纳出提高检测结果可靠性的方法结论.     

New Strategies and Methods to Study Interactions between Tobacco Mosaic Virus Coat Protein and Its Inhibitors

Studies of the targets of anti-viral compounds are hot topics in the field of pesticide research. Various efficient anti-TMV (Tobacco Mosaic Virus) compounds, such as Ningnanmycin (NNM), Antofine (ATF), Dufulin (DFL) and Bingqingxiao (BQX) are available. However, the mechanisms of the action of these compounds on targets remain unclear. To further study the mechanism of the action of the anti-TMV inhibitors, the TMV coat protein (TMV CP) was expressed and self-assembled into four-layer aggregate disks in vitro, which could be reassembled into infectious virus particles with TMV RNA. The interactions between the anti-TMV compounds and the TMV CP disk were analyzed by size exclusion chromatography, isothermal titration calorimetry and native-polyacrylamide gel electrophoresis methods. The results revealed that assembly of the four-layer aggregate disk was inhibited by NNM; it changed the four-layer aggregate disk into trimers, and affected the regular assembly of TMV CP and TMV RNA. The four-layer aggregate disk of TMV CP was little inhibited by ATF, DFL and BQX. Our results provide original data, as well as new strategies and methods, for research on the mechanism of action of anti-viral drugs.     

Mucoadhesive liposomes as ocular delivery system: physical,microbiological, and in vivo assessment

Background: Mucoadhesive drug delivery is a promising strategy to overcome ocular biopharmaceutical constraints. Objective and methods: Ciprofloxacin HCl-loaded reverse phase evaporation liposomes were coated with different concentrations and molecular weights of mucoadhesive biocompatible chitosan polymer to form chitosomes. This colloidal mucoadhesive system was evaluated in vitro and in vivo with respect to deliver the antibiotic to ocular surface. Results and conclusion: The results obtained pointed out that liposome coating process resulted in entrapment efficiency reduction and higher chitosan concentration, and molecular weight showed a more pronounced effect. No morphological differences between coated and uncoated liposomes were observed. Diffusion was the drug release mechanism from chitosomes. Concerning rheological behavior, pseudoplastic flow was characteristic to the prepared chitosomal dispersions. In addition, chitosan coating improved the ocular permeation of ciprofloxacin HCl. Microbiologically; this formulated system enhanced antimicrobial activity of ciprofloxacin HCl against both Gram-positive and Gram-negative bacteria. Moreover, this mucoadhesive system was able to inhibit the growth of Pseudomonas aeruginosa in rabbits' eyes for 24 hours when compared to the marketed preparation. In vivo bacterial conjunctivitis model elucidated that symptoms were controlled by the prolonged release formulation such as that done by the marketed product.     

Carboxylic acid mediated self-assembly of small molecules for organic thin film transistors

A p-type small molecule bearing dicarboxylic acid functional group (–COOH) is synthesized and evaluated for field-effect transistor properties. We discover and report for the first time, that the –COOH groups assist in the passivation of surface traps on the dielectric layer and simultaneously facilitate the self-assembly of the molecules via inter-molecular hydrogen bonding resulting in crystalline active channels. A 9-fold decrease in the threshold voltage was observed for the transistors made using the –COOH functionalized molecule, QT-DA, compared to its ester analogue, QT-ES, providing an evidence of surface passivation. This resulted in an increase in the hole mobility of QT-DA by up to 2 orders of magnitude. It was shown that QT-DA adopts a vertical alignment with respect to the substrate due to preferential interaction between the –COOH groups and the SiO₂ surfaces.     

脉冲电镀Ni—W钻头电参数优选

论述了脉冲电参数的理论选择原则；探讨了脉冲电参数对Ni—W镀层性能的影响规律；介绍了脉冲电镀钻头的室内使用情况。