城市街道分水口对洪水流态转换过程影响研究

随着城市化进程加快和全球气候变化加剧,城市洪涝灾害频发。研究城市街道的行洪特征,掌握城市建筑物对洪水流动的影响机理,对城市洪涝灾害治理具有重要的理论意义和应用价值。本文开展了城市建筑物对洪水运动影响的物理模型试验,在街道两侧布设分水口模拟建筑物不连续的分流效果,分析分水口位置及流量变化对洪水流态转化及水跃形态的影响。观测上游来流量变化、分水口位置等因素对洪水从急流向缓流过渡时的动力特征的影响,包括水跃发生位置、水跃形态转变、水跃漩滚长度、跃前和跃后水深比及分流比等。     

城市社区尺度降雨径流快速模拟——以福州市一排水小区为例

随着城市化进程的不断加快,我国城市正面临着越来越严峻的洪涝问题。本文在社区尺度上构建雨洪管理模型（SWMM）,使用遗传算法率定SWMM模型参数;在对研究区降雨分析的基础上,采用模糊识别法筛选出最具代表性的两种雨型;基于不同的降雨情景与SWMM模拟值组成的数据集,建立长短期记忆神经网络（LSTM）模型模拟研究区降雨径流关系,并使用不同工况评估了LSTM模型效果。结果表明,LSTM模型对降雨径流的模拟与SWMM模型基本吻合,而其对洪峰流量的拟合略有偏差。在较小降雨下,LSTM模型模拟洪峰流量较SWMM输出结果偏小;在较大降雨下,模拟结果偏大;在中等降雨时,模拟效果最好。此外,50个隐含层单元的拟合效果更好,但同时更多的隐含层单元对洪峰流量拟合效果更好。     

The dynamic evolution of aggregated lithium dendrites in lithium metal batteries

Lithium (Li) metal anodes promise an ultrahigh theoretical energy density and low redox potential,thus being the critical energy material for next-generation batteries.Unfortunately,the formation of Li den-drites in Li metal anodes remarkably hinders the practical applications of Li metal anodes.Herein,the dynamic evolution of discrete Li dendrites and aggregated Li dendrites with increasing current densities is visualized by in-situ optical microscopy in conjunction with ex-situ scanning electron microscopy.As revealed by the phase field simulations,the formation of aggregated Li dendrites under high current den-sity is attributed to the locally concentrated electric field rather than the depletion of Li ions.More specif-ically,the locally concentrated electric field stems from the spatial inhomogeneity on the Li metal surface and will be further enhanced with increasing current densities.Adjusting the above two factors with the help of the constructed phase field model is able to regulate the electrodeposited morphology from aggregated Li dendrites to discrete Li dendrites,and ultimately columnar Li morphology.The methodol-ogy and mechanistic understanding established herein give a significant step toward the practical appli-cations of Li metal anodes.     

 基于混合模型的优化低频低压减载方法研究

文中以低频低压情况下保证电压稳定的前提下减载为研究内容,提出了一种基于混合模型的优化低频低压减载方法。该混合模型将遗传算法与人工神经网络相结合,在保证电压稳定的情况下选择合适的节点进行负荷切除。实验结果表明,该方法可以在低频低压情况下使负荷减载量达到最小。     

计及灵活性储备的含风电多微电网系统分布式协调调控策略

高比例风电的接入和需求响应技术的应用对分布式架构下的多微电网系统有功功率动态平衡提出了更高的要求,有必要充分利用灵活性资源对系统进行协调调控.提出一种新颖的灵活性电池储备模型对多微电网系统灵活性备用容量进行评估,定义虚拟灵活性电池储备模型对风电场备用与需求响应负荷备用进行评估,充分挖掘其调频的潜在能力.在此基础上,基于一致性算法求解该模型下各微电网的功率分配,提出计及灵活性储备的含风电多微电网系统分布式协调调控策略,实现分布式架构下灵活性资源的协调优化.通过华东某地区实际数据验证了所提策略的有效性.算例结果表明,协调优化源-荷灵活性储备资源在保障风电消纳的同时,实现了分布式架构下系统的动态功率平衡.     

Pathogenic Hydrogel? A Novel-Entrapment Neuropathy Model Induced by Ultrasound-Guided Perineural Injections

Entrapment neuropathy (EN) is a prevalent and debilitative condition caused by a complex pathogenesis that involves a chronic compression–edema–ischemia cascade and perineural adhesion that results in excessive shear stress during motion. Despite decades of research, an easily accessible and surgery-free animal model mimicking the mixed etiology is currently lacking, thus limiting our understanding of the disease and the development of effective therapies. In this proof-of-concept study, we used ultrasound-guided perineural injection of a methoxy poly(ethylene glycol)-b-Poly(lactide-co-glycoilide) carboxylic acid (mPEG-PLGA-BOX) hydrogel near the rat’s sciatic nerve to induce EN, as confirmed sonographically, electrophysiologically, and histologically. The nerve that was injected with hydrogel appeared unevenly contoured and swollen proximally with slowed nerve conduction velocities across the injected segments, thus showing the compressive features of EN. Histology showed perineural cellular infiltration, deposition of irregular collagen fibers, and a possible early demyelination process, thus indicating the existence of adhesions. The novel method provides a surgery-free and cost-effective way to establish a small-animal model of EN that has mixed compression and adhesion features, thus facilitating the additional elucidation of the pathophysiology of EN and the search for promising treatments.     

Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model

Preeclampsia (PE) is characterized by the onset of hypertension (≥140/90 mmHg) and presence of proteinuria (>300 mg/L/24 h urine) or other maternal organ dysfunctions. During human PE, renal injuries have been observed. Some studies suggest that women with PE diagnosis have an increased risk to develop renal diseases later in life. However, in human studies PE as a single cause of this development cannot be investigated. Here, we aimed to investigate the effect of PE on postpartum renal damage in an established transgenic PE rat model. Female rats harboring the human-angiotensinogen gene develop a preeclamptic phenotype after mating with male rats harboring the human-renin gene, but are normotensive before and after pregnancy. During pregnancy PE rats developed mild tubular and glomerular changes assessed by histologic analysis, increased gene expression of renal damage markers such as kidney injury marker 1 and connective-tissue growth factor, and albuminuria compared to female wild-type rats (WT). However, four weeks postpartum, most PE-related renal pathologies were absent, including albuminuria and elevated biomarker expression. Only mild enlargement of the glomerular tuft could be detected. Overall, the glomerular and tubular function were affected during pregnancy in the transgenic PE rat. However, almost all these pathologies observed during PE recovered postpartum.     

Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

Resveratrol can affect the physiology or biochemistry of offspring in the maternal–fetal animal model. However, it exhibits low bioavailability in humans and animals. Fifteen-week SD pregnant female rats were orally administered bisphenol A (BPA) and/or resveratrol butyrate ester (RBE), and the male offspring rats (n = 4–8 per group) were evaluated. The results show that RBE treatment (BPA + R30) compared with the BPA group can reduce the damage caused by BPA (p < 0.05). RBE enhanced the expression of selected genes and induced extramedullary hematopoiesis and mononuclear cell infiltration. RBE increased the abundance of S24-7 and Adlercreutzia in the intestines of the male offspring rats, as well as the concentrations of short-chain fatty acids (SCFAs) in the feces. RBE also increased the antioxidant capacity of the liver by inducing Nrf2, promoting the expression of HO-1, SOD, and CAT. It also increased the concentration of intestinal SCFAs, enhancing the barrier formed by intestinal cells, thereby preventing BPA-induced metabolic disruption in the male offspring rats, and reduced liver inflammation. This study identified a potential mechanism underlying the protective effects of RBE against the liver damage caused by BPA exposure during the peri-pregnancy period, and the influence of the gut microbiota on the gut–liver axis in the offspring.     

An Engineered sgsh Mutant Zebrafish Recapitulates Molecular and Behavioural Pathobiology of Sanfilippo Syndrome A/MPS IIIA

Mucopolysaccharidosis IIIA (MPS IIIA, Sanfilippo syndrome type A), a paediatric neurological lysosomal storage disease, is caused by impaired function of the enzyme N-sulfoglucosamine sulfohydrolase (SGSH) resulting in impaired catabolism of heparan sulfate glycosaminoglycan (HS GAG) and its accumulation in tissues. MPS IIIA represents a significant proportion of childhood dementias. This condition generally leads to patient death in the teenage years, yet no effective therapy exists for MPS IIIA and a complete understanding of the mechanisms of MPS IIIA pathogenesis is lacking. Here, we employ targeted CRISPR/Cas9 mutagenesis to generate a model of MPS IIIA in the zebrafish, a model organism with strong genetic tractability and amenity for high-throughput screening. The sgsh^Δex5−6 zebrafish mutant exhibits a complete absence of Sgsh enzymatic activity, leading to progressive accumulation of HS degradation products with age. sgsh^Δex5−6 zebrafish faithfully recapitulate diverse CNS-specific features of MPS IIIA, including neuronal lysosomal overabundance, complex behavioural phenotypes, and profound, lifelong neuroinflammation. We further demonstrate that neuroinflammation in sgsh^Δex5−6 zebrafish is largely dependent on interleukin-1β and can be attenuated via the pharmacological inhibition of Caspase-1, which partially rescues behavioural abnormalities in sgsh^Δex5−6 mutant larvae in a context-dependent manner. We expect the sgsh^Δex5−6 zebrafish mutant to be a valuable resource in gaining a better understanding of MPS IIIA pathobiology towards the development of timely and effective therapeutic interventions.