Hypoxia/Temperature/pH Triple Stimuli–Responsive Block Copolymers: Synthesis,Self-Assembly,and Controlled Drug Release

The amphiphilic block copolymer poly(methacrylic acid-co-2-nitroimidazole acrylate)-b-poly(2-(N,N-dimethylamino)ethyl methacrylate) (P(MAA-co-NIMA)-b-PDMAEMA) with the hypoxia/temperature/pH triple responsiveness is synthesized by reversible addition-fragmentation chain transfer polymerization (RAFT), hydrolysis, and 3-(3-dimethylaminopropyl)-1-ethylcarbodiimide (EDC) reactions, and successfully self-assembled into micelles. The hypoxia response in vitro is realized, and then the sensitivity of the self-assembled micelles to the hypoxia condition is studied by controlling the grafting amount of aminated 2-nitroimidazole. Because 2-(N,N-dimethylamino) ethyl methacrylate (DMAEMA) is a typical material sensitive to temperature and pH conditions, the self-assembled micelles are also responsive to temperature and different acidic/basic conditions. In addition, the cumulative release rate of doxorubicin (DOX) at 42 °C, pH = 6.0, and hypoxic conditions increases significantly, and verifies the synergistic promotion effect of the above stimulations. This intelligent polymer with triple response mechanism improves the controllability and efficiency of drug release, and is expected to be a drug carrier for cancer treatment.     

SPV490钢轧后在线热处理工艺研究

研究了SPV490钢控轧后在线直接淬火、回火工艺参数与其力学性能之间的关系。分析了不同的工艺参数对钢板组织及性能的影响。结果表明:经奥氏体再结晶区和未再结晶区两阶段结合控制轧制后在线930℃直接淬火、640℃回火,钢板可获得均匀、细小的回火索氏体组织,其综合力学性能均超过标准要求。     

多元靶碰撞级联中的粒子能量

用一种推广的幂指数散射截面求解了溅射输运方程，获得更加一般的渐近解，这个渐近解不但以Urbassek等人几年前所给出的两个解为其特殊情况，而且还为作者提出的SC解提供了新的证据，此外通过计算并分析了Vicanek等人发表的新的输运理论，发现他们所提出的转换理论结果与Monte Carlo模拟结果一致是不正确的。     

中厚板控制冷却过程的轧件跟踪

控制轧制与控制冷却技术所组成的热机械轧制工艺得到了广泛应用。其中精确的板坯跟踪是保证轧钢过程自动化的前提条件。文中较详细地介绍了热机械轧制过程的板坯跟踪方法。     

反对称矩阵的外在美和内在美的教学呈示

关于对称矩阵的美韵,笔者已经撰文做过研究,而反对称矩阵的美韵并不亚于对称矩阵。本文对反对称矩阵之美亦从“内”与“外”进行分析和探索。     

PP/SBS/EVA三元共混改性制备汽车仪表板专用料的研究

聚丙烯（PP）由于具有价格低、原材料丰富、力学均衡性好、耐化学腐蚀等特点，近年来成为最热门的汽车零部件材料。本文以聚丙烯为基体树脂，热塑性丁苯橡胶（SBS）为主增韧剂，乙烯/醋酸乙烯共聚物（EVA）为辅助增韧剂，通过三无共混改性制备汽车仪有板专用料，并对改性的聚丙烯的材料的冲击强度、弯曲强度、弯曲模量、拉伸强度、断裂伸长率、收缩率、熔体流动速率进行测试。应用正交设计，确定了制备汽车仪表板专用料最佳配方。     

Adhesion Mechanisms of Polyurethanes to Glass Surfaces I. Structure-Property Relationships in Polyurethanes and Their Effects on Adhesion to Glass

Polyurethanes were prepared from toluene diisocyanate (TDI), 1-4-butane diol (BDO) and polycaprolactone-based triols with varying molecular weights. Among each molecular weight triol-based urethane, hard segment content was varied from 20% to 70%. Differential scanning calorimetry, tensile testing, and Iosipescu shear testing were done on all the various urethanes prepared. Thermal characterization data revealed the dependence of phase separation on hard segment content as well as on the triol molecular weight. Tensile data and Iosipescu shear data further confirmed the observations made from the DSC data. The data further indicated that phase separation can greatly improve the modulus of cross-linked segmented urethanes. Adhesion of these urethanes to glass surface was evaluated using soda-lime float glass plate. Urethane samples were cast on the air side of the glass plates and adhesion was measured in shear mode. Adhesion data indicated that in addition to hard segment content, modulus, cross-link density, and molecular weight of the triols, phase separation seems to be a major factor in controlling adhesion. Surfaces of the failed adhesion samples were also analyzed and the failure mode was found to be cohesive, in varying degree, with the different urethane systems.     

Bubble Formation at a Rotating Cylindrical Surface in Cross‐Flowing Liquid

A novel method of gas sparging from a rotating cylinder is proposed, which prevents against formation of large attached gas cavities in cross‐flowing liquids including those flowing downwards. Experimental and theoretical results regarding critical rotation speed necessary to remove the attached cavity, bubble formation process and size distribution of the produced bubbles in a low viscosity system (air‐water) are presented in this study.     

Insect sex pheromones

The half-lives (t _1/2) for evaporative loss ofn-alkyl andn-alkenyl acetates from rubber septa were determined at temperatures varying from 15 to 35 °C. The changes int _1/2 with temperature gave high correlations with the equation, Int _1/2 = H/RT+y _o where H is the heat of vaporization,R is the gas constant,T is the absolute temperature, andy _o is a constant. Half-lives changed dramatically with temperature and the degree of change with temperature increased with increasing molecular weight. For mixtures, component ratios changed with temperature, but the degree was modest. At 20 °C there was a 7.5-fold ratio oft _1/2 between members of the homologousn-alkyl orn-alkenyl acetates differing by two carbon atoms. The large change int _1/2 with temperature and with number of carbon atoms is a consequence of the thermodynamic relationships and the temperature range of pheromone usage. Therefore, a similar degree of change inf _1/2 with temperature and number of carbon atoms will apply to other formulations of the same type (those in which the rate of evaporation is first order). The values oft _1/2 at 20 °C mainly agreed very well with those reported previously at room temperature. However, our previously reported values for pentadecyl and hexadecyl acetate were revised. Half-lives were shown to depend on the vapor pressure of a compound in the formulation substrate, but not on the vapor pressure of the pure compound.Mention of a commercial or proprietary product does not constitute an endorsement by the USDA.     

纺丝侧吹风空调系统的节能措施分析

分析了纺丝侧吹风空调机组及送回风系统设计及其自动控制系统配置的节能措施。合理选择送风余压、送风量、送风温度、送风相对湿度等工艺参数以及空调机组的形式,正确利用回风和自动控制方式,加强生产运行管理,有利于节能。