复合外加剂对铬铁渣基复合材料水化机理的影响

采用X射线粉末衍射(XRD)、差热-热重同步热分析仪(TG-DSC)、扫描电子显微镜(SEM)等分析铬铁渣基复合材料的水化产物的物相组成、微观结构和形貌特征,用甲醇法测定了复合材料的孔隙率。研究了复合外加剂对复合材料水化性能的影响及其作用机理。研究表明:掺入外加剂能显著提高复合材料的早期强度,水化初期大量的钙矾石(AFt)和水化硅酸钙凝胶(C-SH)是复合材料早期强度的主要来源,水化后期外加剂能促进铬铁渣、矿渣等的二次水化反应,使其水化速度增长较快。C-S-H凝胶的不断形成和增多及其对体系孔隙的填充使复合材料的结构更加致密。     

基于控制理论的主动队列RED稳态分析

针对RED算法的参数设置对算法性能具有较大影响的问题,基于自动控制理论,将期望队列长度作为系统输入,将瞬时队列长度作为系统输出,构建了在系统输入和扰动作用下的RED单位反馈控制系统．提出了较传统条件更为精确的稳定条件。并分析计算了稳态误差．仿真结果表明。在稳定条件下。随着分组丢弃函数斜率的增加,RED队列波动增加,在稳定条件边界附近队列波动急剧增加．     

水环境监测与评价系统设计及应用

近年来,水生态环境遭到巨大破坏,建立和完善系统的、专业的水环境监测与评价系统,对水体污染的控制与防治起重要指导作用。设计并开发水环境监测与评价系统,通过报表、图表等,结合在线和离线分析技术,对水质数据变化趋势进行直观展示。将机器学习运用到水质评价中,提高运算的效率及准确度。针对水质时间序列数据的不确定特性建立水质预测模型,对水质中参数在未来一段时间中的含量进行预测,解决水质时间序列多元性、时变性、非线性、耦合性等特点所导致的预测建模困难和管理难度增加的问题,并得到较高的预测精度。该系统集水质数据监测、管理、预警功能为一体,在长泰枋洋水利枢纽得到应用,取得良好的效果。     

Molecular Dynamics of CYFIP2 Protein and Its R87C Variant Related to Early Infantile Epileptic Encephalopathy

The CYFIP2 protein (cytoplasmic FMR1-interacting protein 2) is part of the WAVE regulatory complex (WRC). CYFIP2 was recently correlated to neurological disorders by the association of the R87C variant with early infantile epileptic encephalopathy (EIEE) patients. In this set of syndromes, the epileptic spasms and seizures since early childhood lead to impaired neurological development in children. Inside the WRC, the variant residue is at the CYFIP2 and WAVE1 protein interface. Thus, the hypothesis is that the R87C modification weakens this interaction, allowing the WRC complex’s constant activation. This work aimed to investigate the impacts of the mutation on the structure of the WRC complex through molecular dynamics simulation. For that, we constructed WRC models containing WAVE1-NCKAP1 proteins complexed with WT or R87C CYFIP2. Our simulations showed a flexibilization of the loop comprising residues 80–110 due to the loss of contacts between internal residues in the R87C CYFIP2 as well as the key role of residues R/C87, E624, and E689 in structural modification. These data could explain the mechanism by which the mutation impairs the stability and proper regulation of the WRC.     

基于数据仓库的宏观经济监测预警系统的设计

宏观经济监测预警是对宏观经济进行总体的、综合的、全面的、系统的分析与判断,是运用理论分析方法、经验分析方法、数理统计方法等对宏观经济循环波动这一特定现象进行一整套经济监测、经济评价的体系。介绍了宏观经济监测预警系统的实现环境、预警指标体系的设计、数据仓库的设计以及系统的总体设计。并在此基础上,简要地介绍相关子系统的功能。     

Genetic LGALS1 Variants Are Associated with Heterogeneity in Galectin-1 Serum Levels in Patients with Early Arthritis

Galectin 1 (Gal1) exerts immunomodulatory effects leading to therapeutic effects in autoimmune animal models. Patients with rheumatoid arthritis have been reported to show higher Gal1 serum levels than the healthy population. Our study aimed to find genetic variants on the Gal1 gene (LGALS1) modulating its expression and/or clinical features in patients with early arthritis (EA). LGALS1 was sequenced in 53 EA patients to characterize all genetic variants. Then, we genotyped rs9622682, rs929039, and rs4820293, which covered the main genetic variation in LGALS1, in 532 EA patients. Gal1 and IL-6 serum levels were measured by ELISA and Gal1 also by western blot (WB) in lymphocytes from patients with specific genotypes. Once disease activity improved with treatment, patients with at least one copy of the minor allele in rs9622682 and rs929039 or those with GG genotype in rs4820293 showed significantly higher Gal1 serum levels (p < 0.05). These genotypic combinations were also associated with higher Gal1 expression in lymphocytes by WB and lower IL-6 serum levels in EA patients. In summary, our study suggests that genetic variants studied in LGALS1 can explain heterogeneity in Gal1 serum levels showing that patients with higher Gal1 levels have lower serum IL-6 levels.     

EPZS运动估计算法的分析及改进

在分析研究H.264视频编码标准推荐的运动估计核心算法EPZS的基础上,针对该算法运动估计实时性不足的缺点,提出一种对EPZS算法进行起始搜索窗口中心点和计算终止条件判断标准的改进方法,在H.264编码器的参考模型JM10.1中,选择5个测试序列进行实验。实验结果表明,改进后的算法与原算法相比,在重建图像质量和码率接近的情况下,运动估计时间平均节省了29.314%,降低了算法的复杂度,提高了编码的实时性。     

基于早期随机检测(RED)算法的拥塞避免策略

RED算法采用随机丢弃策略,避免传统尾部丢弃方式而引起的TCP全局同步,同时通过控制队列的长度来抑制拥塞的发生     

油田预警分析模型的研究与设计

目前我国大部分的石油产区已经进入生产开采的中后期,此时为了能够提高石油的采收率来满足社会生产生活,必须及时有效地对油田的产量进行预警分析。本文提出一种油田预警分析模型,该模型采用支持向量机方法对油田开发过程中的油田区块进行预警,并且对抽油单井进行实时的监控与诊断,分析可能出现的各种问题,进而可以在异常事件初期及时发现生产中的异常情况,以此来进行预警,提前采取预防措施,从而实现油田产量的稳产高产。实验结果证明该模型具有较高的预测准确性。     

浅谈数据库安全审计与访问控制的实施及意义

数据安全审计与访问控制系统,可以使风险管理要实现从被动转变到主动,开展事中和事前的监督和检查,防患于未然,充分发挥管理监督和防范风险的效能。