Learning to Locate Informative Features for Visual Identification

Object identification is a specialized type of recognition in which the category (e.g. cars) is known and the goal is to recognize an object’s exact identity (e.g. Bob’s BMW). Two special challenges characterize object identification. First, inter-object variation is often small (many cars look alike) and may be dwarfed by illumination or pose changes. Second, there may be many different instances of the category but few or just one positive “training” examples per object instance. Because variation among object instances may be small, a solution must locate possibly subtle object-specific salient features, like a door handle, while avoiding distracting ones such as specular highlights. With just one training example per object instance, however, standard modeling and feature selection techniques cannot be used. We describe an on-line algorithm that takes one image from a known category and builds an efficient “same” versus “different” classification cascade by predicting the most discriminative features for that object instance. Our method not only estimates the saliency and scoring function for each candidate feature, but also models the dependency between features, building an ordered sequence of discriminative features specific to the given image. Learned stopping thresholds make the identifier very efficient. To make this possible, category-specific characteristics are learned automatically in an off-line training procedure from labeled image pairs of the category. Our method, using the same algorithm for both cars and faces, outperforms a wide variety of other methods.     

计算机辅助药物设计在新药研究中的应用

计算机辅助药物设计（CADD）是在计算机技术、分子药理学和分子生物学等多学科交叉发展的基础上形成的药物研发新技术,它的快速发展,极大地减少了新药创制的盲目性和偶然性。该文在介绍了CADD原理、方法及策略的基础上,对CADD在新药研发中的应用进展进行了回顾,并对其存在问题和应用前景进行了展望。     

计算机病毒发展的新趋势研究

该文对计算机病毒呈现的新的发展趋势进行了分析,针对新的趋势,提出了计算机病毒防治的几点建议。     

基于品牌策略的新产品开发设计

本文通过对企业的品牌策略及其特征的分析,结合具体实例,从产品自身、系列产品和不同类产品形象的"家族"产品三个方面,提出了新产品开发设计如何与品牌策略融合,从而为企业降低新产品开发的风险,提高人们对品牌的认知度,提升企业整体文化形象提供了一种思维方法。     

用现代设计包装传统民间艺术精粹——潍坊年画的包装设计研究

潍坊年画具有浓郁的乡土气息和淳朴鲜明的艺术风格,在包装设计中应通过分析潍坊年画的精神内涵和吉祥寓意,通过对色彩、图形、文字等表象性要素的设计探索,抓住年画文化的本质和精神核心,把它融入到具体设计中,将年画传统的文化思想精髓同当代设计要素有机结合起来,创造具有鲜明艺术个性的包装设计形式。     

坦克设计新发展

本文提出“针对式坦克发展战略”主要内容,它要求“突破性新概念高新技术”,获得“减法设计方法”,因而形成“坦克发展新道路”.运用“系统总体取胜”的系统工程理论,处理好坦克全系统“综合”、全系统与分系统“配置”、分系统与分系统“匹配”、全系统与人及作战环境“适应”四大关系,以“相互同水平组合”替代“单项高水平爬坡”.通过“从系统总体着眼、由边际零部件突破”的途径,善于从各个部分或部件之间的结合部加以突破,实现坦克设计新发展.     

Boosting the confidence of new product development teams: The role of team boundary spanning,team size and functional diversity

In today's highly interconnected, uncertain and dynamic business environment, team boundary spanning has become an important determinant of the performance of new product development (NPD) projects. Despite the positive evidence supporting the use of boundary spanning activities by NPD teams, little is still known about how boundary spanning teams become high-performance teams. The current study advances research on this subject by examining the mediating effect of team potency on the relationship between team boundary spanning and new product performance, as well as the moderating effects of team size and functional diversity on the relationship between team boundary spanning and team potency. Data from a time-lagged survey study of 140 NPD projects found that team boundary spanning can promote team potency that, in turn, results in greater new product quality and new product creativity. The positive effect of team boundary spanning on team potency was found to be more pronounced for NPD teams of medium size and high levels of functional diversity.     

我国爆破行业发展面临的问题与思考

针对行业发展存在的相关问题与困难,为适应新形势的要求,从国内外经济形势的发展现状出发,阐述了国际经济全球化面临的挑战以及国内经济减速等影响我国爆破行业发展的新形势,对我国爆破行业的发展现状困难与机遇进行了深入分析,特别是对以互联网、大数据和云计算为代表的信息技术以及人工智能的发展对爆破行业即将带来的深刻影响进行了探讨。对当前影响我国爆破行业发展的外部环境、内部机制、监管尺度等相关问题进行了深入思考,提出了调整爆破行业结构、促进企业转型升级、推进企业信息化建设和国际化进程等解决之道,并对主管部门、行业组织如何在推进行业结构调整、企业转型升级中发挥更大作用提出建议。     

Drug self-assembly: A phenomenon at the nanometer scale with major impact in the structure–biological properties relationship and the treatment of disease

Under water-rich conditions, small amphiphilic and hydrophobic drug molecules self-assemble into supramolecular nanostructures. Thus, substantial modifications in their interaction with cellular structures and the ability to reach intracellular targets could happen. Additionally, drug aggregates could be more toxic than the non-aggregated counterparts, or vice versa. Moreover, since self-aggregation reduces the number of effective “monomeric” molecules that interact with the target, the drug potency could be underestimated. In other cases, the activity could be ascribed to the non-aggregated molecule while it stems from its aggregates. Thus, drug self-assembly could mislead from drug throughput screening assays to advanced preclinical and clinical trials. Finally, aggregates could serve as crystallization nuclei. The impact that this phenomenon has on the biological performance of active compounds, the inconsistent and often controversial nature of the published data and the need for recommendations/guidelines as preamble of more harmonized research protocols to characterize drug self-aggregation were main motivations for this review. First, the key molecular and environmental parameters governing drug self-aggregation, the main drug families for which this phenomenon and the methods used for its characterization are described. Then, promising nanotechnology platforms investigated to prevent/control it towards a more efficient drug development process are briefly discussed.     

新型城镇化语境下的阿拉善地毯传统技艺探析

目的研究阿拉善地毯传统技艺传承与保护现状。方法通过田野调查个案并结合民俗学、艺术学的理论对阿拉善地毯进行探析。结论了解新型城镇化进程中该项技艺的生存情况,考察它的传承与保护现状,审视它面临的困境与机遇,分析并探究它的传承与保护对策是极具理论价值与现实意义的。