Design and Evaluation of a Two-Layer Floating Tablet for Gastric Retention Using Cisapride as a Model Drug

A new kind of two-layer floating tablet for gastric retention (TFTGR) with cisapride as a model drug was developed. The in vitro drug release was determined, and the resultant buoyancy and the time-buoyancy curve were plotted. Because of the sodium bicarbonate added to the floating layer, when immersed in simulated gastric fluid (SGF) the tablet expands and rises to the surface, where the drug is gradually released. The in vitro drug release of this kind of two-layer dosage was controlled by the amount of hydroxypropylmethylcellulose (HPMC) in the drug-loading layer. Generally, the more HPMC, the slower the drug releases. Because cisapride has greater solubility in SGF than simulated intestinal fluid (SIF), its in vitro drug dissolution in SGF is faster than in SIF. One of the distinguishing characteristics of this kind of tablet is the separate regulation of buoyancy and drug release. The idea developed in this experiment can be used as a general model for the design of other tablets for gastric retention.     

浮动式液压剪的结构特点及参数计算

本文结合作者的浮动式液压剪的设计、调试体会,分析了液压剪的结构组成,并对液压剪设计所需的一些重要参数进行确定。     

可拆卸式浮动切刀在修边模具中的应用

分析了现有废料切断结构存在的问题及其产生的原因,并针对其弊端提出了一种可拆卸式浮动切刀结构。介绍了可拆卸式浮动切刀的组成、冲裁力的计算、行程和工作过程。该结构不仅提高了产品的表面质量,而且拆卸方便,冲压稳定,极大地提高了工作效率。     

一种对三维芯片中硅通孔进行完整建模与寄生参数提取的有效方法

针对三维芯片中硅通孔（through-silicon via, TSV）的准确电学建模问题,本文提出了一种电阻电容（RC）电路模型以及相应的有效参数提取技术。该电路模型同时考虑了半导体效应与静电场影响,适合于低频与中频的电路信号范围。该方法采用一种基于悬浮随机行走（floating random walk, FRW）算法的静电场电容提取技术,然后将它与刻画半导体效应的MOS电容结合,形成等效电路模型。与Synopsys公司软件Sdevice所采用的对静电场/半导体效应进行完整仿真的方法相比,本文方法计算效率更高,并且也能处理一般的TSV电路版图。对多个含TSV的结构进行了计算实验,结果验证了本文方法在从10KHz到1GHz频率范围内的建模准确性,也显示出它相比Sdevice方法最多有47倍的加速比。     

聚苯胺@粉煤灰漂珠复合材料的导电及介电性能

为获得具有良好电流变性能的分散相粒子,利用γ-氨基丙基三乙氧基硅烷(APTES)修饰粉煤灰漂珠(FAFB),将聚苯胺(PAn)以化学键的方式偶联在修饰后的FAFB(mod-FAFB)表面,形成以mod-FAFB为核、PAn为壳的核-壳结构复合材料。采用FTIR、SEM、数字式四探针以及LCR介电谱仪对PAn@mod-FAFB复合材料的结构与性能进行分析,讨论了不同mod-FAFB含量对PAn@mod-FAFB复合材料导电性能及介电性能的影响。结果表明:以化学键接枝聚合的PAn@mod-FAFB核-壳结构复合材料电导率相对较高,且随mod-FAFB含量的增加而减小;在较低交变电场频率(100~2 000kHz)下其相对介电常数较大,且随mod-FAFB含量的增多,PAn@mod-FAFB复合材料的介电常数明显减小;PAn@mod-FAFB复合材料的介电损耗相对较小,随mod-FAFB含量的增多而急剧减小。     

一种新型有源调压变换器的实现

针对目前普通的电压调整模块的变换器存在输入、输出电压变化量大、变换效率低、占空大等问题,提出了一种带有源浮充平台新型电压调整模块,该模块具有稳定的调压率,同时模块能在不采取均流的情况下自动调节平衡各相感应电流提高其效率,精简了控制电路。对新模块进行了稳、动态试验验证,验证结果证明了新模块理论的正确性。     

Heaving response of a large floating platform

In this paper, we tackle a new dynamic problem of a large floating platform in a heaving harmonic motion due to 9000 performers or people simultaneously jumping in mass events. The objective is to estimate the heaving response of the floating structure so as to establish whether the participants will be at ease during their performances. By assuming the platform as a rigid body, the added mass and the radiation damping coefficient are first estimated. This requires the evaluation of a three-dimensional velocity potential governed by Laplace’s equation. The Green's function method was used to solve the boundary value problem. Based on the estimated added mass and radiation damping, we employ the finite element software NASTRAN to solve the transient dynamic problem for the displacement and acceleration responses. The impulse force used for the transient problem is based on experimentally obtained ground reaction force (due to a human jumping) as measured by using a force plate. As the floating platform may be dismantled and reconfigured into other shapes, two different sizes of floating platform as well as different number of jumps were considered in this study.     

悬浮隧道锚索涡激振动影响因素分析

将锚索运动简化为弹簧质量阻尼系统,锚索周围流场采用RSM(Reynolds Stress Model)结合增强的壁面函数模型计算,利用四阶Runge-Kutta法计算锚索振动方程,并将程序写入FLUENT软件进行流固耦合分析。讨论了锚索质量比、阻尼比、是否考虑流向运动和来流速度对锚索涡激振动的影响,主要结论有：质量比对锚索横向涡激振动幅值影响很小,对约化速度范围影响较大;阻尼比对约化速度范围影响很小,对锚索涡激振动幅值影响较大;在低质量比的情况下,考虑锚索流向运动时,涡激振动幅值比不考虑时偏大。     

Research on floating wind turbines: a literature survey

This article presents a literature survey of research and development on floating wind turbines. The various, proposed conceptual designs for floating platforms used for floating wind turbines are described and the working principles of these various floater concepts are outlined. This is followed by an overview of the research work that has been undertaken pertaining to floating wind turbine technology by several research institutes and the academic community. The research work undertaken to date is reviewed categorically according to the proposed floater concept (spar-buoy type, TLP type, semi-submersible type, pontoon type and others) as per sections 3–7. Based on the research work undertaken thus far, recommendations for future work are suggested.