肿瘤血管内皮生长因子受体PET示踪剂研究进展

摘要：本文对血管内皮细胞生长因子（VEGF）的结构、功能及生理作用，VEGFR的靶向抗肿瘤新生血管生成治疗，VEGF的PET示踪剂分类，采用18F标记的VEGFR酪氨酸激酶抑制剂类合成等几个方面做了简要叙述。     

Application of stochastic filtering for lifetime prediction

This paper introduces a stochastic filtering modeling approach for predicting the remaining lifetime of a component based on information on the stochastic degradation process and uncertain condition monitoring measurements. The model is illustrated by a case study, where the degradation is assumed to be a simplified fatigue crack growth process. The model accounts for uncertainties in both degradation process and condition measurements in a sound way. If completed with information on costs of monitoring, failure and replacement, such model could be used in optimizing both the condition monitoring intervals and, e.g. the replacement time for the component.     

Use of chemical variation and predation as plant defenses byEncelia farinosa against a specialist herbivore

Larvae of the monophagous herbivore,Trirhabda geminata, selectively eat particular plants and plant parts of its natural host,Encelia farinosa. Measurements of leaf damage and larval positions on branches through time support this observation. Time-lapse movie photography revealed that larvae are sufficiently mobile to search most of a plant in a 48-hr period and that aggregations were the result of larval activity and not directly the result of oviposition. Experiments withT. geminata larvae on artificial diets containing a range of natural concentrations of chemical extracts fromE. farinosa leaves showed that the larvae grew significantly slower and had a lower overall survivorship at the high concentration. Combining the results of all choice tests, larvae appeared unable to distinguish between high- and low-concentration agar diets. Considered individually, larval preferences for natural production concentrations changed as the season progressed. Early-season larvae preferred low-concentration leaves, while late-season larvae preferred high-concentrations. Measurements of chemical and nitrogen content of leaves selected by larvae in the field confirmed this pattern. Percent parasitism in field-collected larvae increased with season as the larval population decreased. This combination of slowed growth and increasing parasitism and predation is a putative defense strategy ofEncelia farinosa to prevent adaptation by a specialist herbivore to the total range of compounds elaborated.     

Fracture mechanics global approach concepts applied to creep slow crack growth in a medium density polyethylene (MDPE)

Creep fracture by slow crack growth is studied in a medium density polyethylene at 60 °C and 80 °C. Whereas elastic-plastic fracture mechanics load parameters fail to provide a unique temperature-independent correlation, that of the fracture mechanics for creeping solids C^∗ is proved to be relevant since this parameter correlates very well with the time to failure. Correlation established on both full notched creep tensile and double edge notched tensile tests was validated on cracked gas-pipe samples tested under hydrostatic pressure, extending the use of time to failure versus C^∗ diagram to predict lifetime of engineering components.     

煤中吡啶型氮热解机理的量子化学研究

用密度泛函 ( DFT)方法 ,在 UB3LYP/6- 31 G( d)水平上研究了煤中吡啶型氮的热解机理 ,对热解过程中由于官能团周围环境的不同而形成的三类吡啶自由基进行了量子化学计算 ,通过对键的 Mulliken布居数等计算结果的分析 ,分别得到了这三类自由基的热解途径 .并优化得到了反应物、中间体和产物的几何构型 .计算结果表明 ,吡啶型氮主要是以 HCN的形式释放出来的 .NH3 是 HCN二次反应的产物 .     

基于3DMax技术的胡杨茎生长模拟

植物生长模拟研究,是利用计算机技术以可视化的形式描述植物的生长状态。本研究在综合国内外相关研究成果的基础上,以南疆胡杨茎为研究对象,通过对胡杨茎的生长因子及结构形态的研究,提出一种基于三维结构的胡杨茎生长模型,并运用3DMax技术建模,实现胡杨茎的生长形态的可视化。本研究能促进人们对胡杨生长过程的理解和感知,为分析胡杨结构功能关系、调控生长模式等提供重要参考。     

Simulation of the nitrogen balance in the soil and a winter wheat crop

A simulation model for winter wheat growth, crop nitrogen dynamics and soil nitrogen supply was tested against experimental data. When simulations of dry matter production agreed with measurements, nitrogen uptake was simulated accurately. The total amount of soil mineral nitrogen as well as the distribution of mineral nitrogen over the various soil layers were generally simulated well, except for experiments in which fertilizer was applied late in spring. In these experiments, applied nitrogen disappeared because it could not be accounted for by the model. Some explanations for this disappearance are briefly discussed.     

Slow stable crack growth in high density polyethylenes

The phenomenon of slow stable crack growth in polyethylene is investigated using notched specimens subject to constant load and the concepts of fracture mechanics. The effect of specimen geometry and dimension, the loading and the mode of loading on the applied stress intensity factor versus crack speed ($\text{K}{}_{\mathrm{c}}\text{-}\text{a}\text{?}$) curves has been studied to demonstrate that K_c is the controlling stress parameter for crack growth under suitable conditions. $\text{K}{}_{\mathrm{c}}\text{-}\text{a}\text{?}$ curves are obtained for a high density polyethylene homopolymer in distilled water and in a diluted detergent solution at four different temperatures. Results are also obtained for a much tougher medium density polyethylene copolymer whenever possible. Several mechanisms can be identified from the form of the $\text{K}{}_{\mathrm{c}}\text{-}\text{a}\text{?}$ curves. Two, in particular, have been observed but not explained before: (i) crack growth with a time dependence of 0.25, and (ii) the high $\text{K}{}_{\mathrm{c}}\text{-}\text{a}\text{?}$ slopes for crack growth in a tough copolymer. With the help of scanning electron microscopic studies of the fracture surfaces, (i) is postulated to be due to diffusion controlled void growth process and (ii) is considered to be the result of crack tip blunting effects. From the temperature dependence of crack growth, the activation energy of the diffusion controlled crack growth process is found to coincide with that of the x-relaxation process in polyethylene implying that diffusion controlled crack growth may be related to the motion of main chains in the polymer.     

Influence of modified forms of urea and nitrogen levels on weed growth and grain yield of lowland rice

The growth of weeds and their subsequent reduction of rice yield as affected by N source neem cake coated urea (NCU), dicyandiamide coated urea (DCU), rock phosphate coated urea (RPCU), urea supergranules (USG) and prilled urea (PU) was studied on a clay loam soil at Coimbatore, India. Experiments were conducted in northeast monsoon (NEM) 1981, summer 1982, and southwest monsoon (SWM) 1982 seasons.The crop was associated with eleven weed species, and the dominant weeds wereEchinochloa crus-galli, Cyperus difformis andMarsilea quadrifolia. The weed flora varied between seasons. Deep placement of USG reduced the dry weight of weeds in NEM and summer seasons at 60, 90 and 120 Kg N ha^–1 whereas it increased the dry weight at 60 and 90 but not 120 Kg N ha^–1 in SWM season. The dry weight of weeds decreased with increased N rates for all N sources during NEM and summer seasons. In SWM season, dry weight of weeds increased with increased N rates for all N sources except USG. The grain yield of rice was drastically reduced with the deep placement of USG at 60 but not 120 Kg N ha^–1 in SWM season. The differential effect of the N sources between seasons was due to the change of the weed flora. Dominance ofE. crus-galli during SWM season had greater influence on weed dry weight and grain yield of rice.Nitrogen uptake by weeds was frequently greater in unfertilized plots, particularly in NEM and summer seasons. In SWM season, the apparent fertilizer N recovery by weeds was high for USG. It decreased from 53% for 60 Kg USG-N ha^–1 to 4% for 120 Kg USG-N ha^–1.Contribution from the part of Ph.D. work of the first author at Department of Agronomy, Tamil Nadu Agricultural University, Coimbatore-641 003, Tamil Nadu, India.