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针对石油工业管道上可能存在的各种缺陷类型 ,充分考虑缺陷尺寸、工况载荷、断裂韧度和机械强度等参数的不确定性 ,应用含缺陷压力管系断裂失效风险分析系统软件 (SAPP - 2 0 0 2 )计算管道系统中每个独立缺陷的安全概率 ,并对整个管道系统进行断裂失效风险分析。另外 ,在制定管道的检修计划时 ,可以利用该系统的结构应力分析模块方便地确定出管道应力高度集中部位 ,有针对性地选择焊缝并进行射线探伤 ,使管道的安全状况分析更准确。还可以利用该系统软件的分析结果制定出旨在降低失效风险的管道结构改进措施 ,达到缓解应力集中或使应力集中区与缺陷所在位置分离 ,优化管道结构 ,以较低成本提高管道完整性水平的目的。对提高企业压力管道管理水平具有推动作用 相似文献
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Software plays an increasingly important role in modern safety-critical systems. Although, research has been done to integrate software into the classical probabilistic risk assessment (PRA) framework, current PRA practice overwhelmingly neglects the contribution of software to system risk. Dynamic probabilistic risk assessment (DPRA) is considered to be the next generation of PRA techniques. DPRA is a set of methods and techniques in which simulation models that represent the behavior of the elements of a system are exercised in order to identify risks and vulnerabilities of the system. The fact remains, however, that modeling software for use in the DPRA framework is also quite complex and very little has been done to address the question directly and comprehensively. This paper develops a methodology to integrate software contributions in the DPRA environment. The framework includes a software representation, and an approach to incorporate the software representation into the DPRA environment SimPRA. The software representation is based on multi-level objects and the paper also proposes a framework to simulate the multi-level objects in the simulation-based DPRA environment. This is a new methodology to address the state explosion problem in the DPRA environment. This study is the first systematic effort to integrate software risk contributions into DPRA environments. 相似文献
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ABSTRACT Postmortem structural changes in titin and nebulin filaments were investigated by incubating isolated myofibrils in a solution containing 0.1 mM calcium ions and various concentrations of a protease inhibitor. The inhibition curves showed 2 abnormal steps with increases in the concentration of leupeptin or calpastatin domain I. While the amounts of unchanged titin and nebulin were constant in the 1st step, the 2nd occurred at higher protease inhibitor concentrations. These facts indicated that excess amounts of leupeptin and calpastatin domain I caused deterioration in titin and nebulin properties, thus interfering with the binding of calcium ions. We concluded that the severance of titin and nebulin filaments in the 1st step were induced by calcium ions at 0.1 mM. 相似文献
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Charuhas V. Thakar Orfeas Liangos JeanPierre Yared David A. Nelson Srinivas Hariachar Emil P. Paganini 《Hemodialysis international. International Symposium on Home Hemodialysis》2003,7(2):143-147
Background: Acute renal failure (ARF) after cardiac surgery is associated with significant morbidity and mortality, irrespective of the need for dialysis. Previous studies have attempted to identify predictors of ARF and develop risk stratification algorithms. This study aims to validate the algorithm in an independent cohort of patients that includes a significant proportion of female and black patients and compares two different definitions of renal outcome.
Methods: A large single center cardiac surgery database was examined (n, 24,660; 1993–2000) which included 29.9% females and 3.7% black patients. Post‐operative ARF was defined as: a) ARF requiring dialysis, b) > 50% reduction in creatinine clearance relative to baseline or requiring dialysis. Clinical variables related to baseline renal function and cardiovascular disease were used in recursive partitioning analysis for both outcome definitions. Chi‐square goodness of fit analysis was performed to validate the algorithm.
Results: The frequency of post‐operative ARF requiring dialysis ranged between 0.5 and 15.5% based on the risk categories with the area under the receiver operating characteristic (ROC) curve of 0.78. Using the more inclusive definition of ARF, the frequency was significantly higher ranging from 2.6 to 25%(P < 0.001) with an area under ROC curve of 0.65.
Conclusions: The renal risk stratification algorithm is valid in predicting post‐operative ARF in an independent cohort of patients, well represented by differences in gender and race. Since the need for dialysis remains subjective, a more objective and inclusive definition of ARF may help in identifying a larger number of patients 'at‐risk'. 相似文献
Methods: A large single center cardiac surgery database was examined (n, 24,660; 1993–2000) which included 29.9% females and 3.7% black patients. Post‐operative ARF was defined as: a) ARF requiring dialysis, b) > 50% reduction in creatinine clearance relative to baseline or requiring dialysis. Clinical variables related to baseline renal function and cardiovascular disease were used in recursive partitioning analysis for both outcome definitions. Chi‐square goodness of fit analysis was performed to validate the algorithm.
Results: The frequency of post‐operative ARF requiring dialysis ranged between 0.5 and 15.5% based on the risk categories with the area under the receiver operating characteristic (ROC) curve of 0.78. Using the more inclusive definition of ARF, the frequency was significantly higher ranging from 2.6 to 25%(P < 0.001) with an area under ROC curve of 0.65.
Conclusions: The renal risk stratification algorithm is valid in predicting post‐operative ARF in an independent cohort of patients, well represented by differences in gender and race. Since the need for dialysis remains subjective, a more objective and inclusive definition of ARF may help in identifying a larger number of patients 'at‐risk'. 相似文献
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Tams Insperger Gbor Stpn 《International journal for numerical methods in engineering》2004,61(1):117-141
An updated version of the semi‐discretization method is presented for periodic systems with a single discrete time delay. The delayed term is approximated as a weighted sum of two neighbouring discrete delayed state values and the transition matrix over a single period is determined. Stability charts are constructed for the damped and delayed Mathieu equation for different time‐period/time‐delay ratios. The convergence of the method is investigated by examples. Stability charts are constructed for 1 and 2 degree of freedom milling models. The codes of the algorithm are also attached in the appendix. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献