The EPH/Ephrin System in Bone and Soft Tissue Sarcomas’ Pathogenesis and Therapy: New Advancements and a Literature Review

Musculoskeletal sarcomas represent rare heterogenous malignancies of mesenchymal origin that can be divided in two distinct subtypes, bone and soft tissue sarcomas. Current treatment options combine the surgical excision of local tumors and multidrug chemotherapy to prevent metastatic widespread disease. Due to the grim prognosis that usually accompanies such tumors, researchers have attempted to shed light on the molecular pathways implicated in their pathogenesis in order to develop novel, innovative, personalized therapeutic strategies. Erythropoietin-producing human hepatocellular receptors (EPHs) are tyrosine-kinase transmembrane receptors that, along with their ligands, ephrins, participate in both tumor-suppressive or tumor-promoting signaling pathways in bone and soft tissue sarcomas. The EPH/ephrin axis orchestrates cancerous processes such as cell–cell and cell–substrate adhesion and enhances the remodeling of the intracellular cytoskeleton to stimulate the motility and invasiveness of sarcoma cells. The purpose of our study was to review published PubMed literature to extract results from in vitro, in vivo and clinical trials indicative of the role of EPH/ephrin signaling in bone and soft tissue sarcomas. Based on these reports, significant interactions between the EPH/ephrin signaling pathway and a plethora of normal and abnormal cascades contribute to molecular mechanisms enhancing malignancy during sarcoma progression. In addition, EPHs and ephrins are prospective candidates for diagnostic, monitoring and therapeutic purposes in the clinical setting against bone and soft tissue sarcomas.     

饱和土体中椭圆孔扩张弹塑性解

针对软黏土中的打桩问题,提出一种包含完全排水和完全不排水的柱孔扩张通用求解方法,并基于该方法,采用不排水柱孔扩张理论模拟静压桩打桩过程,并采用修正剑桥模型模拟软黏土的本构关系,同时联立扩孔运动学方程、应力平衡方程、质量守恒方程等建立弹塑性孔扩张偏微分控制方程组,利用相似变换的技术求解该方程组,从而获得半解析解.通过与文献中的解答对比,验证了解答的正确性.

     

一种基于软阈值方法的改进A1/A2极化干涉分类算法

在分析了极化干涉技术的发展现状和发展趋势的基础上,从极化干涉的特殊性入手,分析了干涉相干系数在极化干涉分类中的作用,并且系统分析了基于相干最优优化后的相干系数进行极化干涉分类过程的原理,总结了现有极化干涉分类算法在阈值选择方面存在的不足,阐述了硬阈值方法和软阈值方法的基本原理和它们之间的区别,最后提出基于软阈值方法的改进A1/A2非监督极化干涉分类算法,解决了极化干涉分类现有的分类空间中的阈值问题。实验表明这种方法能够得到更好的分类结果,做出了改进。     

饱水石灰岩骨架和流体弹性参数的估算

本文利用Niu等提出的基于临界孔隙度模型的组分弹性参数数值计算方法,把测试岩石样品的孔隙度、整体密度、纵波速度和横波速度作为数值计算的输入数据,运用双线性数值计算方法反演求出临界点、流体和骨架的12个弹性参数。具体做法是:基于临界孔隙度模型,给出三组线性关系,即密度—孔隙度,整体剪切模量—孔隙度,整体纵波模量—孔隙度,上述每组线性关系分别以孔隙度作为自变量和因变量得到两个线性方程,再把两个方程计算的结果进行加权平均得到相关的弹性参数估算值,并结合饱水石灰岩样品数据实现了弹性参数估算。数值计算结果表明,由数值计算得到的弹性参数与测试弹性参数的均值和方差相差甚微,特别是密度数据的偏差均值更小,说明文中的数值计算结果是可靠的。     

高负载环境下基于Linux系统的防火墙软中断性能改善研究

当网络负载增大到一定程度后,基于Linux防火墙的数据转发性能开始下降。最常见的瓶颈是系统软中断在单一CPU上耗用达到100％。本文对这一问题进行了分析并提出了一种易于实现且性能改善明显的解决方案。     

试论涪陵榨菜软实力的提升

涪陵榨菜属地理标志商标,是涪陵的重要软实力之一。认识涪陵榨菜的软实力,加大营销力度,提升涪陵榨菜的国际知名度,有利于推动涪陵榨菜健康与快速发展。文章从软实力的含义、涪陵榨菜硬实力和固有软实力的体现、提升涪陵榨菜软实力的途径与措施进行了论述。     

An experimental study on self-output-control characteristics of micro downwind rotor with coning soft blades

In this short paper,we have treated the aerodynamic performance of micro downwind rotor with coning soft blades experimentally.The test wind rotor has the tip diameter of 1.5 m and three two-dimensional NACA0018 blades of 0.15 m chord whose material is light,soft and pliable foam plastic for perfect safety.From the wind tunnel test,it is realized that the performance is manageable by the coning angle of the rotor blade.In the present case,an improvement of the performance in lower wind speeds is achieved by...     

基于有限元的桩基础内力分析及设计

通过工程实例,利用结构通用软件Midas建立桩承台有限元模型进行受力及变形计算,对结果进行统计分析得到一系列结论,进一步指导工程设计,明确指出在一些情况下需要对规范得到的结果进行修正,并提出了具体的修正方法。     

玻璃钢加砂管在软土地基中的应用

主要分析并指出了新型材料在软土地质环境中的应用,并提出了解决软土中存在问题的方法,保证了新型材料在不同的条件正常施工,从而保证了管网的安全运行。