青海省祁连县热水沟铁矿地质特征及成因探讨

热水沟铁矿矿体主要受早奥陶世阴沟群地层控制,其成因为火山—沉积变质矿床,找矿标志为早奥陶世阴沟群及矿区内磁异常。     

垂直线生产的可锻铸铁管件缺陷改进措施

针对垂直线生产可锻铸铁管件出现的较严重的气孔、夹渣、缩松缺陷,分析缺陷产生原因,并通过优化浇注系统、排气方式及增设集渣包等改进措施实施,解决了可锻铸铁管件气孔、夹渣、缩松缺陷.     

硅对蠕墨铸铁热分析特征值及蠕化率的影响

试验设计了 5种不同硅含量的蠕墨铸铁铁液,分析了硅含量对蠕墨铸铁凝固的热分析曲线特征值TEU、TER、△Tr和蠕墨铸铁蠕化率的影响.试验结果表明:(1)在本次试验的硅含量范围内,蠕墨铸铁热分析曲线的特征值TEU和TER先是随着硅的增加而上升,然后,变化不明显;(2)蠕墨铸铁共晶温度回升特征值△Tr随着硅含量的增加呈下降...     

某铁矿井下多工作面协同爆破智能管控体系研究

基于某铁矿穿孔和爆破工序分割、多中段多工作面同时作业的工程背景,采用跟踪调研的方法得出该铁矿具有爆破作业管控难度大、工序反馈衔接不及时、有效作业人员占比小等问题。以解决上述难题为目的,采用工序分析、问题提出、风险评估等层层递进的方法,开展井下多工作面协同爆破智能管控体系研究,其结果表明：井下爆破作业各工序间具有严谨的先后顺序;爆破器材运输和装药工序的危险程度最高,需精准管控;采用智能软件协同监管多工作面爆破作业工序,不仅精准管控效率高,还可降低矿山爆破作业的事故机率。最后结合某铁矿的实际作业条件,基于多工作面同时爆破作业的先后流程,采用Python语言开发了井下多工作面协同爆破智能管控软件,并通过爆破作业工作面的管理调试,证明研发的管控软件适合辅助该铁矿爆破工序的监管。     

改进固相法制备LiFePO4/C正极材料及其性能

采用改进的固相反应法制备了掺碳的磷酸铁锂正极材料,并用XRD,SEM,元素分析,红外光谱及激光粒度分布仪等对样品进行了测试分析.结果表明,样品具有单一的橄榄石结构和较好的放电平台(约3.4V),粒度较小粒径分布均匀,0.1C首次放电比容量为137.8mAh/g,循环20次后容量保持率为92.6%,以1C倍率首次放电比容量为129.6mAh/g,循环20次后容量下降10.8%.     

纳米LiFePO4/C复合正极材料的制备及其性能研究

采用碳热还原方法、以不同掺碳(葡萄糖为碳源)方式合成LiFePO4/C复合正极材料,利用X射线衍射仪、高倍率透射电镜以及电池测试仪等手段对样品进行了分析研究,并探讨了不同掺碳方式对复合LiFePO4/C正极材料性能的影响.结果表明,采用湿法加入葡萄糖制备的LiFePO4/C正极材料中LiFePO4的粒径范围在40～80nm左右,为纳米材料尺度,0.05C倍率下首次放电比容量达到160mAh/g,1C倍率下循环50次后,容量衰减仅为1.2%.     

崩落采矿形成冰碛补给型泥石流相似模拟试验

崩落采矿法形成的冰碛补给型泥石流作为发育在高寒山区的特殊地质灾害类型,给矿山的安全高效开采造成了严重影响.为研究崩落空间发展过程与泥石流之间的关系,开展了相似模拟试验,模拟降雨条件下崩落采矿法的放矿过程,研究矿石、冰碛物、水等3种因素对泥石流形成的影响,结果表明:随着放矿的进行,矿石中混有地表冰碛物的量越来越多,放出的...     

Multi-scale mechanistic modelling of the host defence in invasive aspergillosis reveals leucocyte activation and iron acquisition as drivers of infection outcome

Aspergillus species are ubiquitous environmental moulds, with spores inhaled daily by most humans. Immunocompromised hosts can develop an invasive infection resulting in high mortality. There is, therefore, a pressing need for host-centric therapeutics for this infection. To address it, we created a multi-scale computational model of the infection, focused on its interaction with the innate immune system and iron, a critical nutrient for the pathogen. The model, parameterized using published data, was found to recapitulate a wide range of biological features and was experimentally validated in vivo. Conidial swelling was identified as critical in fungal strains with high growth, whereas the siderophore secretion rate seems to be an essential prerequisite for the establishment of the infection in low-growth strains. In immunocompetent hosts, high growth, high swelling probability and impaired leucocyte activation lead to a high conidial germination rate. Similarly, in neutropenic hosts, high fungal growth was achieved through synergy between high growth rate, high swelling probability, slow leucocyte activation and high siderophore secretion. In summary, the model reveals a small set of parameters related to fungal growth, iron acquisition and leucocyte activation as critical determinants of the fate of the infection.     

Ferritinophagy and α-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson’s Disease

A major hallmark of Parkinson’s disease (PD) is the fatal destruction of dopaminergic neurons within the substantia nigra pars compacta. This event is preceded by the formation of Lewy bodies, which are cytoplasmic inclusions composed of α-synuclein protein aggregates. A triad contribution of α-synuclein aggregation, iron accumulation, and mitochondrial dysfunction plague nigral neurons, yet the events underlying iron accumulation are poorly understood. Elevated intracellular iron concentrations up-regulate ferritin expression, an iron storage protein that provides cytoprotection against redox stress. The lysosomal degradation pathway, autophagy, can release iron from ferritin stores to facilitate its trafficking in a process termed ferritinophagy. Aggregated α-synuclein inhibits SNARE protein complexes and destabilizes microtubules to halt vesicular trafficking systems, including that of autophagy effectively. The scope of this review is to describe the physiological and pathological relationship between iron regulation and α-synuclein, providing a detailed understanding of iron metabolism within nigral neurons. The underlying mechanisms of autophagy and ferritinophagy are explored in the context of PD, identifying potential therapeutic targets for future investigation.     

贵溪鲍家矿业公司选别工艺改造实践

根据原矿的矿物特性,在试验研究的基础上,将原混合浮选工艺改造成优先浮选工艺,产出了合格的单一铅、锌精矿产品,从而调整了产品结构,取得了较好的选矿技术指标,公司新增经济效益明显.