A Triple‐Collaborative Strategy for High‐Performance Tumor Therapy by Multifunctional Mesoporous Silica‐Coated Gold Nanorods

To integrate treatments of photothermal therapy, photodynamic therapy (PDT), and chemotherapy, this study reports on a multifunctional nanocomposite based on mesoporous silica‐coated gold nanorod for high‐performance oncotherapy. Gold nanorod core is used as the hyperthermal agent and mesoporous silica shell is used as the reservoir of photosensitizer (Al(III) phthalocyanine chloride tetrasulfonic acid, AlPcS₄). The mesoporous silica shell is modified with β‐cyclodextrin (β‐CD) gatekeeper via redox‐cleavable Pt(IV) complex for controlled drug release. Furthermore, tumor targeting ligand (lactobionic acid, LA) and long‐circulating poly(ethylene glycol) chain are introduced via host–guest interaction. It is found that the nanocomposite can specifically target to hepatoma cells by virtue of the LA targeting moiety. Due to the abundant existence of reducing agents within tumor cells, β‐CD can be removed by reducing the Pt(IV) complex to active cisplatin drug for chemotherapy, along with the releasing of entrapped AlPcS₄ for effective PDT. As confirmed by in vitro and in vivo studies, the nanocomposite exhibits an obvious near‐infrared induced thermal effect, which significantly improves the PDT and chemotherapy efficiency, resulting in a superadditive therapeutic effect. This collaborative strategy paves the way toward high‐performance nanotherapeutics with a superior antitumor efficacy and much reduced side effects.     

Tunable Nanoparticle and Cell Assembly Using Combined Self‐Powered Microfluidics and Microcontact Printing

The combination of cell microenvironment control and real‐time monitoring of cell signaling events can provide key biological information. Through precise multipatterning of gold nanoparticles (GNPs) around cells, sensing and actuating elements can be introduced in the cells' microenviroment, providing a powerful substrate for cell studies. In this work, a combination of techniques are implemented to engineer complex substrates for cell studies. Alternating GNPs and bioactive areas are created with micrometer separation by means of a combination of vacumm soft‐lithography of GNPs and protein microcontract printing. Instead of conventional microfluidics that need syringe pumps to flow liquid in the microchannels, degas driven flow is used to fill dead‐end channels with GNP solutions, rendering the fabrication process straightforward and accessible. This new combined technique is called Printing and Vacuum lithography (PnV lithography). By using different GNPs with various organic coating ligands, different macroscale patterns are obtained, such as wires, supercrystals, and uniformly spread nanoparticle layers that can find different applications depending on the need of the user. The application of the system is tested to pattern a range of mammalian cell lines and obtain readouts on cell viability, cell morphology, and the presence of cell adhesive proteins.     

Au‐Decorated Cracked Carbon Tube Arrays as Binder‐Free Catalytic Cathode Enabling Guided Li2O2 Inner Growth for High‐Performance Li‐O2 Batteries

Owing to their extremely high energy density, Li‐O₂ batteries have attained increasing attention in recent studies. However, deposition of the discharge product, insulating Li₂O₂, is known to seriously limit the electrochemical performance of Li‐O₂ batteries. While extensive studies have focused on relieving electrode deactivation by controlling Li₂O₂ growth, no permanent or effective mechanism is delivered. Here, a unique design comprising a catalytic cathode constructed by cracked carbon submicron tube (CST) arrays decorated with Au nanoparticles on inner walls is proposed. The introduction of Au nanoparticles not only improves electrode conductivity but also provides catalytic sites, guiding conformal growth of thin‐layered Li₂O₂ inside the cracked CST. Density functional theory calculations support that Au decoration on CST favors the conformal growth of Li₂O₂ on inner tubular walls. This growth behavior of Li₂O₂ renders easy decomposition of Li₂O₂, prevents carbon tube electrode from full, rapid deactivation, and preserves the free space for reactants transport. Li‐O₂ cells with Au@CST exhibit good rate capability (1208 mAh g^–1 at a high current density of 1000 mA g^–1) and long cycle life (112 cycles at a current density of 400 mA g^–1 with a limited capacity of 500 mAh g^–1).     

High Performance,Multiplexed Lung Cancer Biomarker Detection on a Plasmonic Gold Chip

Diagnosis of lung cancer is performed using a plasmonic gold (pGOLD) chip through multiplexed near‐infrared (NIR) detection of carcino‐embryonic antigen (CEA), Cyfra21‐1, and neuron‐specific enolase (NSE) in the serum samples of patients. With ≈50‐fold enhancement of NIR fluorescence, multiplexed microarray analysis of CEA, Cyfra21‐1, and NSE in 10 μL of human serum or whole blood samples on pGOLD chip leads to markedly improved limit‐of‐quantification, limit‐of‐detection, reproducibility, and higher diagnostic sensitivity and specificity compared to traditional biochips and Luminex technology currently in use in hospitals.     

Correlating equations for free convection heat transfer from horizontal isothermal cylinders set in a vertical array

Steady laminar free convection from flat vertical arrays of equally-spaced, horizontal isothermal cylinders set in free air, is studied numerically. A specifically developed computer-code based on the SIMPLE-C algorithm is used for the solution of the mass, momentum and energy transfer governing equations. Simulations are performed for arrays of 2-6 circular cylinders, for center-to-center separation distances from 2 up to more than 50 cylinder-diameters, and for values of the Rayleigh number based on the cylinder-diameter in the range between 5 × 10² and 5 × 10⁵. It is found that the heat transfer rate at the bottom cylinder remains the same as a single cylinder. In contrast, the downstream cylinders may exhibit either enhanced or reduced Nusselt numbers depending on their location in the array and on the geometry of the array. Heat transfer dimensionless correlating equations are proposed both for any individual cylinder in the array and for the whole tube-array. New correlation-equations for the calculation of the heat transfer rate from a single cylinder to the surrounding air are also proposed and compared to those available in the open literature.     

小秦岭大湖金矿区深部矿体原生晕特征及其找矿应用

矿床原生晕地球化学轴向分带是深部矿体预测的重要依据。金成矿成晕具有多期多阶段叠加特点,本文通过对大湖矿区矿体原生晕元素进行统计分析和空间分布特征研究,总结了大湖矿区金矿体的原生晕理想模型:即前缘晕元素组合为As、Sb,近矿晕元素组合为Bi、Au、Ag、Mo、Pb、Cu,矿尾晕元素组合为Mn、Zn、V、Co、Ni。根据原生晕特征进行成矿预测,经过工程验证,在8线发现4层金矿体,在4线发现1层金矿体,取得了较好的找矿效果,为小秦岭金矿田其他矿区的深部找矿勘探提供了参考。     

Physical properties of G-class cement for geothermal well cementing in South Korea

The cement material adopted for a new geothermal well project in South Korea is specialized as the G-class cement, which is commonly used in the oil-well industry, and regulated by the API (American Petroleum Institute). In order to maintain the optimal generating performance of geothermal wells, physical properties of the cementing material should be satisfactory. In this paper, the significant material properties (i.e., groutability, uniaxial compressive strength, thermal conductivity, bleeding potential, phenolphthalein indication) of the G-class cement were experimentally examined, with consideration of various water–cement (w/c) ratios as mix proportion. Important findings through the experiments are as follows; (1) Groutability of the G-class cement increases with the addition of a small amount of retarder. (2) There would be a structural problem when the w/c ratio is kept extremely high in order to obtain acceptable groutability. (3) Thermal conductivity of the G-class cement is small enough to prevent heat loss during circulating up hot steam or water from the deep underground to the ground surface. (4) The G-class cement used for geothermal-well cementing causes no bleeding problem. (5) The phenolphthalein indicator is applicable to distinguishing the G-class cement from the drilling mud.     

密闭式免维护铅酸蓄电池的进展

本文对小型密闭式铅酸蓄电池几个有关的问题加以介绍,不仅概括电池的发展简史,更着重电池的结构、密闭的技术、电解液的制配和隔板的使用,旨在加深人们对密闭铅蓄电池的认识,促进该电池的发展。     

Ion-beam etched multi-level resist technique for electroplating of submicron gold absorber patterns

A structuring process is developed which enables the fabrication of gold patterns by electroplating with a minimum linewidth of ? 0.3 μm. These patterns are used as mask patterns for X-ray lithography. They can be up to 1.6 μm thick. For this purpose, a resist pattern, which is generated by an electron beam, is transmitted to a multi-layer system by reactive ion-beam etching. The multi-layer system consists of a 2 μm thick polyimide layer, a 70 nm thick aluminum intermediate layer and a 30 nm thick gold passivation layer.With this process, X-ray masks with a polyimide membrane were produced and utilized for exposure to synchrotron radiation.