Soluble Epoxide Hydrolase Blockade after Stroke Onset Protects Normal but Not Diabetic Mice

Soluble epoxide hydrolase (sEH) is abundant in the brain, is upregulated in type 2 diabetes mellitus (DM2), and is possible mediator of ischemic injury via the breakdown of neuroprotective epoxyeicosatrienoic acids (EETs). Prophylactic, pre-ischemic sEH blockade with 4-[[trans-4-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]cyclohexyl]oxy]-benzoic acid (tAUCB) reduces stroke-induced infarct in normal and diabetic mice, with larger neuroprotection in DM2. The present study tested whether benefit occurs in normal and DM2 mice if tAUCB is administered after stroke onset. We performed 60 min middle cerebral artery occlusion in young adult male C57BL mice divided into four groups: normal or DM2, with t-AUCB 2 mg/kg or vehicle 30 min before reperfusion. Endpoints were (1) cerebral blood flow (CBF) by laser Doppler, and (2) brain infarct at 24 h. In nondiabetic mice, t-AUCB reduced infarct size by 30% compared to vehicle-treated mice in the cortex (31.4 ± 4 vs. 43.8 ± 3 (SEM)%, respectively) and 26% in the whole hemisphere (26.3 ± 3 vs. 35.2 ± 2%, both p < 0.05). In contrast, in DM2 mice, tAUCB failed to ameliorate either cortical or hemispheric injury. No differences were seen in CBF. We conclude that tAUCB administered after ischemic stroke onset exerts brain protection in nondiabetic but not DM2 mice, that the neuroprotection appears independent of changes in gross CBF, and that DM2-induced hyperglycemia abolishes t-AUCB-mediated neuroprotection after stroke onset.     

Visceral Adipose Tissue Displays Unique Metabolomic Fingerprints in Obesity,Pre-Diabetes and Type 2 Diabetes

Visceral adipose tissue (VAT) metabolic profiling harbors the potential to disentangle molecular changes underlying obesity-related dysglycemia. In this study, the VAT exometabolome of subjects with obesity and different glycemic statuses are analyzed. The subjects (n = 19) are divided into groups according to body mass index and glycemic status: subjects with obesity and euglycemia (Ob+NGT, n = 5), subjects with obesity and pre-diabetes (Ob+Pre-T2D, n = 5), subjects with obesity and type 2 diabetes under metformin treatment (Ob+T2D, n = 5) and subjects without obesity and with euglycemia (Non-Ob, n = 4), used as controls. VATs are incubated in culture media and extracellular metabolite content is determined by proton nuclear magnetic resonance (¹H-NMR). Glucose consumption is not different between the groups. Pyruvate and pyroglutamate consumption are significantly lower in all groups of subjects with obesity compared to Non-Ob, and significantly lower in Ob+Pre-T2D as compared to Ob+NGT. In contrast, isoleucine consumption is significantly higher in all groups of subjects with obesity, particularly in Ob+Pre-T2D, compared to Non-Ob. Acetate production is also significantly lower in Ob+Pre-T2D compared to Non-Ob. In sum, the VAT metabolic fingerprint is associated with pre-diabetes and characterized by higher isoleucine consumption, accompanied by lower acetate production and pyruvate and pyroglutamate consumption. We propose that glucose metabolism follows different fates within the VAT, depending on the individuals’ health status.     

Highly Thermal Stable Polyimides Applied in Flexible Resistive Memory

Flexible memory devices are one of the most crucial elements in the wearable electronics. In this work, polyimides (PIs)-based flexible resistive memory devices with an excellent thermal and mechanical durability are demonstrated. Four kinds of functional PIs are derived from the heterocyclic diamines including 2,6-diaminodibenzo-p-dioxin (OODA) and 2,6-diaminothianthrene, and dianhydrides including 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) and 3,3′,4,4′-biphenyltetracarboxylic dianhydride. PI with diamine of OODA and dianhydride of 6FDA (PI(OODA_6FDA)) possesses outstanding thermal and mechanical properties with a high glass transition temperature of 352 °C, a low coefficient of thermal expansion of 28.1 ppm K⁻¹, and a high elongation at break of 10%. In addition, PI(OODA_6FDA)-based memory shows write-once-read-many behavior with a high on/off current ratio of 10⁶ and a stable data retention, attributed to the donor–acceptor charge transfer between the polymer chains. The retained current levels at a low resistive state can be observed even with thermal treatment at 200 °C for 24 h or 1000 times cyclic bending at a bending radius of 5 mm. These results demonstrate the potential of heterocyclic PIs for flexible resistive memory.     

管模工艺的优化

管模是生产离心球墨铸铁管的模具,其毛坯的锻造成型非常困难。本文介绍了管模锻造工艺的优化过程。采用优化后的工艺,解决了管模在锻造生产中出现的各种问题,使管模的成品率大幅提高。同时也为长筒型锻件的成型提供了可靠的参考依据。     

微机控制热丝GTA全位置焊管系统

本文介绍了新开发的微机控制热丝钨极氢弧焊焊管系统，旨在提高焊接速度及质量以适应生产发展的需要，控制系统利用焊接电板为传感器，通过软件来实现焊接程序、焊接规范的自动变换，焊接参数的自动控制及以焊缝的自动跟踪和示教跟踪，具有抗干扰性强，精度高，反应快、柔性强及体积小等优点，特别适合于野外现场施工。     

铜管内部阴极保护电位分布公式探讨

简述了管道内部阴极保护时电位分布公式的推导过程，重点推导和分析了双点阳极时其电位公式，并与文献中的同类公式进行了比较，同时，用该公式检验了试验结果。     

热轧无缝钢管芯棒润滑剂

介绍了用于热轧无缝钢管芯棒的新型石墨润滑剂的高温润滑性能，润滑机组及工业使用情况。实践证明，新型石墨润滑剂完全满足热轧无缝钢管的工艺要求，并与进口产品性能相似，且具有操作简便、环境污染小等优点。     

缩进式管子-管板焊接工艺

管子-管板焊接是换热器生产的关键工序,通过对缩进式管子-管板焊接技术进行的试验和分析,确定了最佳的焊接参数,供换热器制造厂有关技术人员参考.     

水平电磁连铸空心铜管坯组织和性能研究

提出在中试水平的空心铜管坯水平连铸过程中施加工频电磁场,分析其对铜管坯组织和性能的影响.结果表明：与未施加电磁场时相比,施加电流强度为140A的工频电磁场后,水平连铸空心铜管坯的组织显著细化,平均晶粒度由未施加磁场时的3.1提高到8.3,周向组织均匀性也得到明显改善;抗拉强度提高40%左右,延伸率提高50%左右.