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Alexandra Kodadová Zuzana Vitková Petra Herdová Anton Ťažký Jarmila Oremusová Daniel Grančai 《Drug development and industrial pharmacy》2015,41(7):1080-1088
This study deals with the formulation of natural drugs into hydrogels. For the first time, compounds from the sage essential oil were formulated into chitosan hydrogels. A sample preparation procedure for hydrophobic volatile analytes present in a hydrophilic water matrix along with an analytical method based on the gas chromatography coupled with the mass spectrometry (GC-MS) was developed and applied for the evaluation of the identity and quantity of essential oil components in the hydrogels and saline samples. The experimental results revealed that the chitosan hydrogels are suitable for the formulation of sage essential oil. The monoterpene release can be effectively controlled by both chitosan and caffeine concentration in the hydrogels. Permeation experiment, based on a hydrogel with the optimized composition [3.5% (w/w) sage essential oil, 2.0% (w/w) caffeine, 2.5% (w/w) chitosan and 0.1% (w/w) Tween-80] in donor compartment, saline solution in acceptor compartment, and semi-permeable cellophane membrane, demonstrated the useful permeation selectivity. Here, (according to lipophilicity) an enhanced permeation of the bicyclic monoterpenes with antiflogistic and antiseptic properties (eucalyptol, camphor and borneol) and, at the same time, suppressed permeation of toxic thujone (not exceeding its permitted applicable concentration) was observed. These properties highlight the pharmaceutical importance of the developed chitosan hydrogel formulating sage essential oil in the dermal applications. 相似文献
3.
为了成功预测竹林山煤矿综放高瓦斯矿井大采高工作面煤层瓦斯涌出量,以主采3号煤层为主要研究对象,针对3号煤层以往开采情况,通过布设测点测量其煤层瓦斯含量和了解相邻矿井瓦斯含量,采用分源预测法、回归法及统计法等预测方法得到了3号煤层瓦斯含量的分布规律,并绘制了3号煤层的瓦斯含量等值线图。对矿井不同生产时期的瓦斯含量进行预测,得到了生产前期、中期及后期采区的最大绝对瓦斯涌出量和最大相对瓦斯涌出量,说明了竹林山煤矿各个时期均属于高瓦斯矿井。 相似文献
4.
Prediction of methane adsorption content in continental coal-bearing shale reservoir using SLD model
Shale gas, as an important unconventional resource, has drawn global attention. It is mainly composed of adsorption gas and free gas. Adsorption gas content could play an important guiding role on both the selection of favorable perspective area and the exploration and exploitation of shale gas resources. In order to accurately measure adsorption gas content, a new approach was established to predict the adsorption isotherm of methane on shale. Based on the simplified local-density (SLD) method, both the adsorption isotherms of illite, illite/smectite mixed-layer, cholorite and type III kerogen and the total shale rock could be well fitted. The fitting results show good coincidences with the true experimental test data, which proves the method is reasonable and dependable and the prediction results are effective and credible. In addition, the good simulation results show that the SLD parameters can reflect the pore structure characteristics and corresponding adsorption characteristics of the shale samples, which can be used for the quantitative characterization of shale pore system. 相似文献
5.
For rechargeable wireless sensor networks, limited energy storage capacity, dynamic energy supply, low and dynamic duty cycles cause that it is unpractical to maintain a fixed routing path for packets delivery permanently from a source to destination in a distributed scenario. Therefore, before data delivery, a sensor has to update its waking schedule continuously and share them to its neighbors, which lead to high energy expenditure for reestablishing path links frequently and low efficiency of energy utilization for collecting packets. In this work, we propose the maximum data generation rate routing protocol based on data flow controlling technology. For a sensor, it does not share its waking schedule to its neighbors and cache any waking schedules of other sensors. Hence, the energy consumption for time synchronization, location information and waking schedule shared will be reduced significantly. The saving energy can be used for improving data collection rate. Simulation shows our scheme is efficient to improve packets generation rate in rechargeable wireless sensor networks. 相似文献
6.
《Oil and Energy Trends》2019,44(1):26-28
Current data on natural gas production, as well as a breakdown of production by country. Updated on a monthly basis. 相似文献
7.
Abiodun B. Ogbesejana Zhong Ningning Oluwadayo O. Sonibare 《Petroleum Science and Technology》2019,37(18):1969-1977
The occurrence and distributions of dibenzofurans (DBFs) and benzo[b]naphthofurans were investigated in crude oils from Niger Delta, Nigeria, by gas chromatography-mass spectrometry-mass spectrometry. The distribution of DBFs was characterized by the predominance of C2-dibenzofurans. 4-Methyldibenzofuran was the most abundant among the methyldibenzofurans isomers while dimethyldibenzofuran-2 (DMDBF-2), ethyldibenzofuran-1, DMDBF-3, and DMDBF-6 occurred in higher amounts when compared with other DMDBFs. Among the benzonaphthofurans, the abundance of benzo[b]naphtho[2,1-d]furan was higher than other isomers. The DBFs distributions in the oils were not affected by source facies and depositional environments. However, the DBFs concentrations increased with increasing maturity in oils from ADL and MJO oilfields. 相似文献
8.
带有传感器的可穿戴式医疗设备不断生成大量数据,由于数据的复杂性,难以通过处理和分析大数据来找到有价值的决策信息。为了解决这个问题,提出了一种新的物联网体系结构,用于存储和处理医疗应用的可扩展传感器数据(大数据)。所提出的架构主要由两个子架构组成:Meta Fog重定向(MF-R)架构和AWS密钥管理机制。MF-R架构使用Apache Pig和Apache HBase等大数据技术来收集和存储不同传感器设备生成的传感器数据,并利用卡尔曼滤波消除噪声。AWS密钥管理机制使用密钥管理方案,目的是保护云中的数据,防止未经授权的访问。当数据存储在云中时,所提出的系统能够使用随机梯度下降算法和逻辑回归来开发心脏病的预测模型。仿真实验表明,和其他几种算法相比,提出的算法具有更小的误差,且在吞吐量、准确度等方面具有一定的优越性。 相似文献
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10.
Nilesh P. Vanikar Shantipal S. Ohol Saeede Goldar 《International Journal of Cast Metals Research》2018,31(4):249-259
Bottom pour ladles with stopper rod systems are commonly used in the metal casting industry. However, stopper rod bottom-pouring systems have not yet been developed for the lower thermal masses of alloys typically used in the investment casting industry. Large thermal masses used with bottom pour systems are typically limited for ladles larger than 700 kg and to certain alloys with higher fluidity and longer solidification time like cast iron, aluminum alloys etc. In this study, bottom pour ladle designs and low thermal mass refractory systems have been developed and evaluated in production investment foundry trials with 300 kg pouring ladle. The ladles system and pouring practices used will be described along with the results from the pouring trials for SS304 that represents typical alloys used in Investment casting industries. Optimization of the variables used in an experimentation using Genetic algorithm is also explained. 相似文献