一种测量工业环境感应传导干扰的方法

针对采用干扰测量仪或频谱分析仪只能测量工业环境中干扰源的辐射干扰强度的问题,提出了一种测量工业环境感应传导干扰的方法。该方法采用HBYV非双绞2芯线作为干扰接收体,采用数字示波器记录干扰波形的最大幅值和单个脉冲的最大强度,通过与标准干扰发生器感应到HBYV非双绞2芯线上的干扰信号大小进行比较,确定干扰强度。以瞬变脉冲群干扰强度和浪涌干扰强度的测量为例,详细介绍了该方法的具体实现。     

高压带电体温度检测装置

针对传统高压带电体测温方法存在的难以实现电气绝缘、精度低等问题,介绍了一种新型高压带电体温度检测装置的设计方案。该装置采用传统接触式测温方式下的温度传感器采集温度信号,采用可调电流源+感生电源方式实现供电,各感生电源与可调电流源通过高压线连接,不同测温点的感生电源之间没有电气连接,且采用光纤传输温度信号,从而很好地实现了电气绝缘。实验结果表明,该装置的感生电源电压稳定,测温精度高,抗干扰能力强。     

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本文把与井简直接连通的大裂缝及井筒定义为“裂缝—井筒系统”,通过气体状态方程的变换和续流总量的计算,探索出井底大裂缝的容积及其储量的计算方法。     

冶炼工艺对GH871合金涡轮盘韧性的影响

研究了AIM ESR和VIM ESR两种冶炼工艺对GH871合金涡轮盘三种韧性指标的影响,结果表明:冶炼工艺对该合金在室温、650℃拉伸和缺口冲击韧性影响较小,采用VIM ESR冶炼工艺可以显著提高GH871合金在700℃拉伸韧性和I型裂纹平面应变的断裂韧性。     

加载速率对结构钢力学性能和断裂韧度的影响

在常温下进行了常用建筑结构钢(16Mn和Q235B钢)动态拉伸和动态断裂韧度试验。试验结果表明，材料在动载下无论是屈服强度还是抗拉强度均有一定的提高，塑性有了一定的降低；由于缺口尖端区域温度的升高，常温下动载对于16Mn钢母材和焊缝的断裂韧度是有利的；Q235B钢常温下，焊缝的断裂韧度值较低，且动载对母材的断裂韧度影响较大，和静载相比动载下断裂韧度值降低了4倍有余，可以看出，Q235B钢的抗震性能较差。通过研究发现，对于低韧度水平的材料，研究动载下结构的断裂行为时．材料的强度也应该作为一个考虑因素。     

Role of HMOX1 Promoter Genetic Variants in Chemoresistance and Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia

Whilst the survival rates of childhood acute lymphoblastic leukemia (ALL) have increased remarkably over the last decades, the therapy resistance and toxicity are still the major causes of treatment failure. It was shown that overexpression of heme oxygenase-1 (HO-1) promotes proliferation and chemoresistance of cancer cells. In humans, the HO-1 gene (HMOX1) expression is modulated by two polymorphisms in the promoter region: (GT)n-length polymorphism and single-nucleotide polymorphism (SNP) A(−413)T, with short GT repeat sequences and 413-A variants linked to an increased HO-1 inducibility. We found that the short alleles are significantly more frequent in ALL patients in comparison to the control group, and that their presence may be associated with a higher risk of treatment failure, reflecting the role of HO-1 in chemoresistance. We also observed that the presence of short alleles may predispose to develop chemotherapy-induced neutropenia. In case of SNP, the 413-T variant co-segregated with short or long alleles, while 413-A almost selectively co-segregated with long alleles, hence it is not possible to determine if SNPs are actually of phenotypic significance. Our results suggest that HO-1 can be a potential target to overcome the treatment failure in ALL patients.     

Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation

Mesenchymal stem cells (MSCs) are multipotent stem cells derived from adult stem cells. Primary MSCs can be obtained from diverse sources, including bone marrow, adipose tissue, and umbilical cord blood. Recently, MSCs have been recognized as therapeutic agents for skin regeneration and rejuvenation. The skin can be damaged by wounds, caused by cutting or breaking of the tissue, and burns. Moreover, skin aging is a process that occurs naturally but can be worsened by environmental pollution, exposure to ultraviolet radiation, alcohol consumption, tobacco use, and undernourishment. MSCs have healing capacities that can be applied in damaged and aged skin. In skin regeneration, MSCs increase cell proliferation and neovascularization, and decrease inflammation in skin injury lesions. In skin rejuvenation, MSCs lead to production of collagen and elastic fibers, inhibition of metalloproteinase activation, and promote protection from ultraviolet radiation-induced senescence. In this review, we focus on how MSCs and MSC-derived molecules improve diseased and aged skin. Additionally, we emphasize that induced pluripotent stem cell (iPSC)-derived MSCs are potentially advanced MSCs, which are suitable for cell therapy.     

iPSC-Cardiomyocyte Models of Brugada Syndrome—Achievements,Challenges and Future Perspectives

Brugada syndrome (BrS) is an inherited cardiac arrhythmia that predisposes to ventricular fibrillation and sudden cardiac death. It originates from oligogenic alterations that affect cardiac ion channels or their accessory proteins. The main hurdle for the study of the functional effects of those variants is the need for a specific model that mimics the complex environment of human cardiomyocytes. Traditionally, animal models or transient heterologous expression systems are applied for electrophysiological investigations, each of these models having their limitations. The ability to create induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs), providing a source of human patient-specific cells, offers new opportunities in the field of cardiac disease modelling. Contemporary iPSC-CMs constitute the best possible in vitro model to study complex cardiac arrhythmia syndromes such as BrS. To date, thirteen reports on iPSC-CM models for BrS have been published and with this review we provide an overview of the current findings, with a focus on the electrophysiological parameters. We also discuss the methods that are used for cell derivation and data acquisition. In the end, we critically evaluate the knowledge gained by the use of these iPSC-CM models and discuss challenges and future perspectives for iPSC-CMs in the study of BrS and other arrhythmias.     

渤海注聚井区油井深部解堵工艺研究及应用

针对渤海油田油井解堵效果变差、有效期降低等问题,提出了扩大解堵半径、优选解堵剂体系、强化解堵效果的解堵思路。通过工艺研究、工艺优选,形成了深穿透解堵技术。深穿透解堵技术主要包含基质解堵、降阻造缝和储层深部解堵三个过程。对深穿透解堵工艺机理进行了研究,并形成了一套现场可应用的工艺技术。针对锦州油田注聚井区堵塞问题,从聚合物溶液降黏、模拟含聚堵塞物、现场含聚堵塞物降解三个方面优选出一种复合解堵剂,结合工艺思路形成施工方案,并进行现场应用,取得了较好的增液、增油效果。     

基于AIE特性的萘酰亚胺衍生物的合成及光谱研究

以分子内电荷转移为原理,选用萘酰亚胺为荧光团,与三苯胺通过偶联反应,制备了一种萘酰亚胺衍生物有机光功能小分子材料,其合成路线简单,实验操作条件易控,成品产率较高。对其光学性能进行研究,在不同溶剂中的光学性能主要表现出两个强吸收带,荧光发射达到到近红外区域,其表现出了非常明显的聚集诱导发光（AIE）特性,固体表现出很强的橘橙色荧光现象。