Tumor-Localized Administration of α-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors

Invariant natural killer T (iNKT) cells have the capacity to mount potent anti-tumor reactivity and have therefore become a focus in the development of cell-based immunotherapy. iNKT cells attack tumor cells using multiple mechanisms with a high efficacy; however, their clinical application has been limited because of their low numbers in cancer patients and difficulties in infiltrating solid tumors. In this study, we aimed to overcome these critical limitations by using α-GalCer, a synthetic glycolipid ligand specifically activating iNKT cells, to recruit iNKT to solid tumors. By adoptively transferring human iNKT cells into tumor-bearing humanized NSG mice and administering a single dose of tumor-localized α-GalCer, we demonstrated the rapid recruitment of human iNKT cells into solid tumors in as little as one day and a significantly enhanced tumor killing ability. Using firefly luciferase-labeled iNKT cells, we monitored the tissue biodistribution and pharmacokinetics/pharmacodynamics (PK/PD) of human iNKT cells in tumor-bearing NSG mice. Collectively, these preclinical studies demonstrate the promise of an αGC-driven iNKT cell-based immunotherapy to target solid tumors with higher efficacy and precision.     

影像设备OM测试法解读(能源之星2.0版)

美国能源之星对影像设备能效测试2.0版操作模式功率法(OM法)主要反应被测样品在完成准备状态、睡眠状态、低耗能状态或关闭状态的能耗情况。分析了OM法的各测试项目以及相应指标,归纳总结了该标准规范在实施中应注意的问题,对影像设备附加功能进行了详细说明。     

变压器绕组直流电阻超标缺陷的综合判断

针对变压器绕组电阻试验数据超标的情况,在对试验数据进行纵向对比的基础上,结合油色谱分析和红外测温图谱分析,判断出变压器的缺陷部位在高压套管V相柱头处,并分析缺陷产生直流电阻超标的原因,提出缺陷处理措施和整改建议。     

基于海洋背景红外图像的仿真系统研究

简要介绍了一种简便的基于海洋背景的红外仿真系统的设计和组成,阐述了各个模块的功能以及模块之间的联系。在实际存储红外图像素材基础上,通过直接添加模板图像,接着通过后续的处理模块来实现较好的模拟海洋红外图像中的目标的目的。从最后的结果可以看到这是一个简便有效的仿真系统。     

基于AT89S52的家庭智能浇花器的设计

设计了家庭智能浇花器,实现花卉的自动浇水.利用单片机实现自动浇花,根据不同的花种,设置了不同的控制方式,即定时定量浇花方式与根据湿度浇花.定时定量浇花是实现每天在规定的时间自动打开电磁阀浇花,根据不同的花卉所需水量不同,用一个按钮来设置浇花时间的长短,即电磁阀打开的时间,其余时间电磁阀闭合,水流不经过;根据湿度控制浇花...     

虚拟现实系统中的视觉延迟研究

视觉延迟将致虚拟现实系统的沉浸感遭到破坏，并导致用户产生运动高，对产生视觉延迟的检测延迟和成像延迟进行了研究。     

红外探测器组网预警技术研究

通过对红外探测器组网的可行性进行分析和对其优化配置,数据接入与融合以及预警系统评估技术进行研究,为发展预警探测系统的集成实验提供了技术支撑,并为提升我国红外探测器组网技术水平提出了一些新的思路.     

星载-机载混合双站SAR回波信号的仿真

对于星载-机载双站合成孔径雷达（SA-BiSAR）系统,回波模拟的关键是计算出卫星、飞机和目标这三者之间的距离。在考虑地球自转的情况下,提出了用坐标变换的方法,解决了近地空间与外太空之间距离的计算问题,实现了任意几何模型下更为精确的SA-BiSAR回波模拟。同时,利用此方法也可获得直达波信号。点目标的仿真展示了SAR回波信号的特征,该方法得到了验证。     

冬青树叶表面的红外光谱特征

用红外衰减全反射技术(ATR)研究了各生长期和不同环境中冬青树叶表面的红外光谱特征.当用黑色塑料袋套在冬青枝条上48 h后,树叶表面的水分有所增加,其它成分变化甚微.当用透明塑料袋套在枝条上48 h后,树叶表面酯类物质的特征峰1 730、1 682 cm-1增加,且峰强度相当.当冬青叶片与甲苯气体接触48 h后,叶片反面酯类物质的特征峰(1 730、1 168、1 039 cm-1)有所减少.同样,叶片正面的酯类物质(1 730、1 168、1 039 cm-1)也有所减少.扫描电镜能谱也证实了叶片反面酯类物质确有减少.     

New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents

Carbonic anhydrase IX (CAIX) is a tumor-specific and hypoxia-induced biomarker for the molecular imaging of solid malignancies. The nuclear- and optical-imaging of CAIX-expressing tumors have received great attention due to their potential for clinical applications. Nuclear imaging is a powerful tool for the non-invasive diagnosis of primary and metastatic CAIX-positive tumors and for the assessment of responses to antineoplastic treatment. Intraoperative optical fluorescence imaging provides improved visualization for surgeons to increase the discrimination of tumor lesions, allowing for safer surgical treatment. Over the past decades, many CAIX-targeted molecular imaging probes, based on monoclonal antibodies, antibody fragments, peptides, and small molecules, have been reported. In this review, we outline the recent development of CAIX-targeted probes for single-photon emission computerized tomography (SPECT), positron emission tomography (PET), and near-infrared fluorescence imaging (NIRF), and we discuss issues yet to be addressed.