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51.
张颖 《南通纺织职业技术学院学报》2006,6(3):52-55
作为中国各种哲学渊源中影响最大的儒家思想,其“差等观”深刻地体现于家庭(族)生活、社会生活、政治和法律生活等方面的理论当中,对中国古代的法思想影响至深.在当代中国的法治建设进程中,应当对传统的“差等观”加以扬弃改造,批判继承,在全社会树立现代的、注入自由平等观的“差等观”. 相似文献
52.
Shuzhen Liu Guoyan An Qing Cao Tong Li Xinyu Jia Lei Lei 《International journal of molecular sciences》2021,22(11)
Increasing numbers of miRNAs have been observed as oncogenes or tumor suppressors in colorectal cancer (CRC). It was recently reported that hsa-miR-106b-5p (miR-106b) promoted CRC cell migration and invasion. However, there were also studies showing contradictory results. Therefore, in the present study, we further explore the role of miR-106b and its downstream networks in the carcinogenesis of CRC. We observed that the expression of miR-106b is significantly increased in Pan-Cancer and CRC tissues compared with normal tissues from The Cancer Genome Atlas (TCGA) database. Furthermore, we used Transwell, Cell Counting Kit-8, and colony formation assays to clarify that miR-106b promotes the migratory, invasive, and proliferative abilities of CRC cells. For the first time, we systematically screened the target mRNAs and lncRNAs of miR-106b using TCGA database and the bioinformatics algorithms. Dual-luciferase reporter assay confirmed that NR2F2-AS1 and PLEKHO2 are the direct targets of miR-106b. Furthermore, NR2F2-AS1 acts as a competing endogenous RNA (ceRNA) to regulate PLEKHO2 expression by sponging miR-106b. The results of Gene set enrichment analysis (GSEA) and Western blot indicated that they play important roles in CRC progression by regulating MAPK pathway. Thus, miR-106b/NR2F2-AS1/PLEKHO2/MAPK signaling axis may suggest the potential usage in CRC treatment. 相似文献
53.
Alexandra Calle Víctor Toribio María Yez-M Miguel ngel Ramírez 《International journal of molecular sciences》2021,22(11)
Embryonic implantation is a key step in the establishment of pregnancy. In the present work, we have carried out an in-depth proteomic analysis of the secretome (extracellular vesicles and soluble proteins) of two bovine blastocysts embryonic trophectoderm primary cultures (BBT), confirming different epithelial–mesenchymal transition stages in these cells. BBT-secretomes contain early pregnancy-related proteins and angiogenic proteins both as cargo in EVs and the soluble fraction. We have demonstrated the functional transfer of protein-containing secretome between embryonic trophectoderm and maternal MSC in vitro using two BBT primary cultures eight endometrial MSC (eMSC) and five peripheral blood MSC (pbMSC) lines. We observed that eMSC and pbMSC chemotax to both the soluble fraction and EVs of the BBT secretome. In addition, in a complementary direction, we found that the pattern of expression of implantation proteins in BBT-EVs changes depending on: (i) their epithelial–mesenchymal phenotype; (ii) as a result of the uptake of eMSC- or pbMSC-EV previously stimulated or not with embryonic signals (IFN-τ); (iii) because of the stimulation with the endometrial cytokines present in the uterine fluid in the peri-implantation period. 相似文献
54.
55.
张竹林 《稀有金属材料与工程》2002,31(2):96-98
用一种推广的幂指数散射截面求解了溅射输运方程,获得更加一般的渐近解,这个渐近解不但以Urbassek等人几年前所给出的两个解为其特殊情况,而且还为作者提出的SC解提供了新的证据,此外通过计算并分析了Vicanek等人发表的新的输运理论,发现他们所提出的转换理论结果与Monte Carlo模拟结果一致是不正确的。 相似文献
56.
57.
从烟(粉)尘排放总量控制、大气污染物排放标准、清洁生产、中水回用、环境绿化和加强环境法制观念等方面,提出强化水泥建设项目环保设计和建设、促进水泥工业可持续发展的想法和建议。 相似文献
58.
New experimental results on pressure loss for the single and two‐phase gas‐liquid flow with non‐Newtonian liquids in helical coils are reported. For a constant value of the curvature ratio, the value of the helix angle of the coils is varied from 2.56° to 9.37°. For single phase flow, the effect of helix angle on pressure loss is found to be negligible in laminar flow regime but pressure loss increases with the increasing value of helix angle in turbulent flow conditions. On the other hand, for the two‐phase flow, the well‐known Lockhart‐Martinelli method correlates the present results for all values of helix angle (2.56‐9.37°) satisfactorily under turbulent/laminar and turbulent/turbulent conditions over the following ranges of variables as: 0.57 ≤ n′ ≤ 1; Re′ < 4000; Rel < 4000; Reg < 8000; 8 ≤ x ≤ 1000 and 0.2 ≤ De′ ≤ 1000. 相似文献
59.
Migration kinetics of straight-chain oligomers and antioxidants from several polyolefins at different temperatures into various solvents have been studied by radioactive tracer techniques. Anhydrous ethanol appears to be a well suited food-oil or liquid-fat simulant for extracting different types of migrants from polyolefins. Pure and mixed triglycerides are also good oil or fat simulants, but the triglycerides offer no simpler analytical procedures than the use of oil or fat themselves. n-Octanol may also be considered as a reasonable oil or fat simulant; however, its action depends somewhat on the choice of migrants. The accelerating action of n-heptane over that of oil or simulants is quantitatively demonstrated. The accelerating effects are greater for migration systems with lower diffusion coefficients. The diffusion coefficients for migration into n-heptane are about 20 times greater than the diffusion coefficients into ethanol or oil for otherwise identical migration systems yielding diffusion coefficients of about 10?7 cm2s?1 into oil or ethanol. For systems yielding diffusion coefficients into oil or ethanol of about 10?12 cm2s?1, the corresponding diffusion coefficients into n-heptane are about 1000 times greater. The molecular weight distributions (MWDs) of the n-heptane and ethanol extracts of polyolefins have been analysed. n-Heptane can not only accelerate the migration of the individual migrant but also remove oligomer species that are slightly soluble or present at low levels in the oil or simulant extracts. 相似文献
60.
Ethylene–propylene–diene terpolymer (EPDM) was modified by bromination reaction. Blending the resulting brominated EPDM with natural rubber (STR5L) and blending the unmodified EPDM with STR5L at various compositions were carried out. The rheological properties of the blends were investigated using a capillary extrusion. Shear flow curves of the pure rubbers and their blends illustrated the pseudoplastic property as shear thinning behavior with a power law index n < 1. True shear viscosity of all blends showed the negative deviation in relation to their additive values. Rheological behavior and two Tg's found from the DSC thermograms at all blend compositions indicated blend incompatibility for both sets of blends. The incompatibility of the vulcanized blends was also found by measuring the spin–spin relaxation time T2 by pulsed NMR. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 837–847, 2003 相似文献