XeF（C-A）蓝绿激光对可见光面阵CCD软损伤的实验研究

建立了脉冲激光辐照CCD器件实验平台,采用XeF（C-A）蓝绿激光辐照可见光CCD,获得CCD出现软损伤（局部饱和、全饱和、串扰及致眩）的激光能量密度阈值或量级及对应的CCD图像,用饱和面积法分析了蓝绿激光对CCD的软损伤效应。     

Complex Elucidation of Cells-of-Origin in Pediatric Soft Tissue Sarcoma: From Concepts to Real Life,Hide-and-Seek through Epigenetic and Transcriptional Reprogramming

Soft tissue sarcoma (STS) comprise a large group of mesenchymal malignant tumors with heterogeneous cellular morphology, proliferative index, genetic lesions and, more importantly, clinical features. Full elucidation of this wide diversity remains a central question to improve their therapeutic management and the identity of cell(s)-of-origin from which these tumors arise is part of this enigma. Cellular reprogramming allows transitions of a mature cell between phenotypes, or identities, and represents one key driver of tumoral heterogeneity. Here, we discuss how cellular reprogramming mediated by driver genes in STS can profoundly reshape the molecular and morphological features of a transformed cell and lead to erroneous interpretation of its cell-of-origin. This review questions the fact that the epigenetic context in which a genetic alteration arises has to be taken into account as a key determinant of STS tumor initiation and progression. Retracing the cancer-initiating cell and its clonal evolution, notably via epigenetic approach, appears as a key lever for understanding the origin of these tumors and improving their clinical management.     

Analysis of factors of top coal caving in fully mechanized sublevel caving face in soft coal and control

According to the analysis of the mechanism of top coal caving, the caving condition was pointed out, and many factors of caving were also determined. Then the relationship between factors and caving was studied. Based on the above research, one effective method by using field monitoring was brought forward to determine the controlling factor. Then some related key technologies were provided, such as keeping the integrality of the top-coal, raising the horizontal resistance of supports and decreasing the real end-face distance etc.. At last one application of this method was presented, and it was proved to be an effective method.     

带FIR滤波的非线性滑动平均动态软测量模型

非线性滑动平均(NMA)模型能有效描述工业过程的动态特性,是一种典型的动态软测量模型.而受限于模型复杂度, NMA模型的输入时序边界相对较窄,难以适应带有大滞后或强测量噪声的动态工业过程.针对该问题,本文将NMA模型与结构简单、输入时序边界宽的FIR滤波器相结合,构造一种非线性、强抗干扰的软测量建模策略.并设计层白化结构来避免二者间的参数耦合现象,采用Adam算法进行同步优化,提高模型的预测精度及训练效率.最后,利用数值仿真和硫回收过程建模实验,验证所提模型的预测精度以及模型设计的合理性.     

基于超图正则化的域适应偏最小二乘多工况软测量模型

针对流程工业中,因多工况导致数据分布变化引起传统软测量模型预测性能恶化问题,本文提出一种基于超图正则化的域适应多工况软测量回归模型框架.首先,采用非线性迭代偏最小二乘回归算法为基模型,在潜变量空间利用历史工况数据重构当前工况数据,以增强工况间的相关性,有效减小数据分布差异;同时,对重构系数施加低秩稀疏约束,保留了数据的局部和全局子空间结构;其次,通过超图拉普拉斯正则项对域适应潜变量求解过程进行约束,避免在寻找潜变量过程中破坏数据结构.最后,利用交替方向乘子法优化求解模型参数.在多个数据集上的实验表明,本文方法在多工况环境下可有效提高软测量模型的预测精度和泛化性能.     

Enapotamab Vedotin,an AXL-Specific Antibody-Drug Conjugate,Demonstrates Antitumor Efficacy in Patient-Derived Xenograft Models of Soft Tissue Sarcoma

Doxorubicin (doxo) remains the standard of care for patients with advanced soft tissue sarcoma (STS), even though response rates to doxo are only around 14% to 18%. We evaluated enapotamab vedotin (EnaV), an AXL-specific antibody-drug conjugate (ADC), in a panel of STS patient-derived xenografts (PDX). Eight models representing multiple STS subtypes were selected from our STS PDX platform (n = 45) by AXL immunostaining on archived passages. Models were expanded by unilateral transplantation of tumor tissue into the left flank of 20 NMRI nu/nu mice. Once tumors were established, mice were randomized into an EnaV treatment group, or a group treated with isotype control ADC. Treatment efficacy was assessed by tumor volume evaluation, survival analysis, and histological evaluation of tumors, and associated with AXL expression. EnaV demonstrated significant tumor growth delay, regression, and/or prolonged survival compared to isotype control ADC in 5/8 STS PDX models investigated. Experimental passages of responding models were all found positive for AXL at varying levels, but no linear relationship could be identified between the level of expression and level of response to EnaV. One model was found negative for AXL on experimental passage and did not respond to EnaV. This study provides a preclinical rationale for the evaluation of AXL-targeting ADCs in the treatment of AXL-expressing sarcomas.     

房间采暖技术与变频调速综述

本文对房间采暖技术的发展状况、技术原理、构造特点进行了归纳总结,重点分析了地板供暖的优缺点,指出了地板供暖技术在房间采暖设计中的应用前景。针对低温地板热水辐射供暖系统存在的一些工程问题,通过对水泵的控制算法的研究和探讨,提出了地板水供暖系统采用以uPD78F1213为核心的无传感器永磁同步电机矢量控制系统的方案。     

特柔软型钢丝铠装复合电缆设计探讨

本文主要探讨特柔软型钢丝铠装复合电缆的设计,根据特殊用户实际应用情况,设计出大拉力、超柔软钢丝铠装电缆,设计过程中不仅考虑电缆所应有的电性能,同时还要考虑电缆高强度抗张情况和应用中处于反复收放状态,而且所设计的电缆还要满足恶劣环境.     

The EPH/Ephrin System in Bone and Soft Tissue Sarcomas’ Pathogenesis and Therapy: New Advancements and a Literature Review

Musculoskeletal sarcomas represent rare heterogenous malignancies of mesenchymal origin that can be divided in two distinct subtypes, bone and soft tissue sarcomas. Current treatment options combine the surgical excision of local tumors and multidrug chemotherapy to prevent metastatic widespread disease. Due to the grim prognosis that usually accompanies such tumors, researchers have attempted to shed light on the molecular pathways implicated in their pathogenesis in order to develop novel, innovative, personalized therapeutic strategies. Erythropoietin-producing human hepatocellular receptors (EPHs) are tyrosine-kinase transmembrane receptors that, along with their ligands, ephrins, participate in both tumor-suppressive or tumor-promoting signaling pathways in bone and soft tissue sarcomas. The EPH/ephrin axis orchestrates cancerous processes such as cell–cell and cell–substrate adhesion and enhances the remodeling of the intracellular cytoskeleton to stimulate the motility and invasiveness of sarcoma cells. The purpose of our study was to review published PubMed literature to extract results from in vitro, in vivo and clinical trials indicative of the role of EPH/ephrin signaling in bone and soft tissue sarcomas. Based on these reports, significant interactions between the EPH/ephrin signaling pathway and a plethora of normal and abnormal cascades contribute to molecular mechanisms enhancing malignancy during sarcoma progression. In addition, EPHs and ephrins are prospective candidates for diagnostic, monitoring and therapeutic purposes in the clinical setting against bone and soft tissue sarcomas.     

现浇混凝土蜂巢空腹楼盖技术的应用

蜂巢空腹楼盖技术是采用蜂巢芯在现浇混凝土板中铸塑成内部空间承力单元,形成传力明确的现浇混凝土双向网格肋空心楼盖水平结构体系。它的传力骨架是通过柱与柱(墙)之间实心暗梁或明梁,结合蜂巢空腹板工肋上下翼缘形成一个大的工字形截面梁,使其抗侧移刚度、位移、强度和变形等各方面均能满足设计要求。