球墨铸铁表面激光熔覆钴基合金涂层的研究

为了研究在球墨铸铁QT600-3基体上熔覆钴基合金,采用6kW CO2激光器进行激光熔覆,用扫描电镜对激光熔覆层进行形貌观察,分析裂纹及气孔的形成原因,取得在球墨铸铁基体上熔覆钴基合金的最佳工艺参数。结果表明,球墨铸铁基体与熔覆层能形成良好的冶金结合,但熔覆功率过高使得熔覆层开裂倾向增大,过渡区及热影响区的球状石墨由原来的“牛眼状”变为单独的石墨球,石墨球外围的环状铁素体出现消溶。     

Developments in iron and steel making

A survey is presented of the direct reduction processes which are presently in commercial operation for the production of iron and steel as an alternative to the classical blast furnace route. The relative advantages and disadvantages of each technology are presented and their relative energy efficiencies discussed.     

Gas-based direct reduction processes for iron and steel production

Gas-based processes for the direct reduction of iron are discussed and compared in terms of their costs and energy effectiveness. Possible future lines of development are presented.     

黄铜超低浓度硝酸酸洗工艺的研究

通过对黄铜酸洗工艺的讨论,采用了超低浓度硝酸新工艺代替硫酸-双氧水体系的老工艺.结果表明:新工艺不仅大大降低了成本,而且零件表面的光洁度、均匀程度及抗变色能力都有了较为明显的提高,并且酸洗时升温较慢,可以连续生产;此外,对三废的处理也进行一定的探讨,新工艺中产生的NOx气体可以得到有效的控制,废液处理量少,同时新工艺中产生的废渣可以直接回收利用.     

锂合金热电池内阻

热电池的内阻大小直接影响着电池的负载能力。热电池的内阻越小,其负载能力越强。依据热电池的具体特点,从它的内部结构、单体电池的厚度、正负极材料、工作温度等几个方面,研究影响热电池内阻的因素。     

铁粉加热药的热值测定

使用煤炭、电力和石化等行业广泛应用的SUNDYSDACM3000量热仪,研究出了热电池用铁粉加热药热值的专用精确测试方法。在SUNDYSDACM3000量热仪的氧弹内加入10mL蒸馏水,使得氧弹内盛装被测样品的坩埚与仪器测试介质间由气体对流热交换改变为强制液体传导热交换;并把测试样品由自然松装法改为在恒定压力下压制成柱状体,确保在反应过程中被测试样品的状态不会发生变化。通过改变SUNDYSDACM3000量热仪设定的热交换方式、改变被测试样的状态,保证了测试结果的准确性和重现性。     

无机絮凝剂在油田水处理中的应用发展

简要介绍了国内外油田水处理用的无机絮凝剂的基本情况。综述了无机高分子絮凝剂的种类、开发情况,重点介绍了聚铝、聚铁、硅酸盐的絮凝机理及在水中的形态,并指出其在油田水处理中的优缺点。提出了当前无机絮凝剂的应用和理论研究及发展方向。     

淀粉基高吸水树脂的微波辐射合成

以微波辐射为引发热源,以玉米淀粉为基材与单体丙烯酸在引发剂过硫酸钾引发下进行接枝共聚,合成高吸水树脂。研究了引发剂用量、微波辐射强度及时间、丙烯酸中和度等因素对产品吸水率的影响。经过优选得到工艺条件为:微波功率137 W,辐射周期20 s,辐射时间30 min,m(丙烯酸):m(淀粉)=2.5∶1,引发剂为单体质量的0.4%,丙烯酸中和度70%,合成的树脂吸水率为619 g/g,吸盐水率为60 g/g。     

基于ANP超级决策软件中的智能评估计算与应用

介绍了基于ANP的超级决策软件的各种复杂计算以及在模糊评估中的应用,包括模糊输入、模糊语言的量化及其它们之间的比较、计算,为实现决策方案的评估提供了一种智能化的手段。最后,从应用的角度给出了Super Decision软件的评估计算,并成功地利用该软件对招标评标项目的不同方案进行了评估。     

SEC23B Loss-of-Function Suppresses Hepcidin Expression by Impairing Glycosylation Pathway in Human Hepatic Cells

Biallelic pathogenic variants in the SEC23B gene cause congenital dyserythropoietic anemia type II (CDA II), a rare hereditary disorder hallmarked by ineffective erythropoiesis, hemolysis, erythroblast morphological abnormalities, and hypo-glycosylation of some red blood cell membrane proteins. Abnormalities in SEC23B, which encodes the homonymous cytoplasmic COPII (coat protein complex II) component, disturb the endoplasmic reticulum to Golgi trafficking and affect different glycosylation pathways. The most harmful complication of CDA II is the severe iron overload. Within our case series (28 CDA II patients), approximately 36% of them exhibit severe iron overload despite mild degree of anemia and slightly increased levels of ERFE (the only erythroid regulator of hepcidin suppression). Thus, we hypothesized a direct role of SEC23B loss-of-function in the pathomechanism of hepatic iron overload. We established a hepatic cell line, HuH7, stably silenced for SEC23B. In silenced cells, we observed significant alterations of the iron status, due to both the alteration in BMP/SMADs pathway effectors and a reduced capability to sense BMP6 stimulus. We demonstrated that the loss-of-function of SEC23B is responsible of the impairment in glycosylation of the membrane proteins involved in the activation of the BMP/SMADs pathway with subsequent hepcidin suppression. Most of these data were confirmed in another hepatic cell line, HepG2, stably silenced for SEC23B. Our findings suggested that the pathogenic mechanism of iron overload in CDA II is associated to both ineffective erythropoiesis and to a specific involvement of SEC23B pathogenic variants at hepatic level. Finally, we demonstrated the ability of SEC23B paralog, i.e., SEC23A, to rescue the hepcidin suppression, highlighting the functional overlap between the two SEC23 paralogs in human hepatic cells.