Sequence‐Specific Molecular Lithography Towards DNA‐Templated Electronics

Recent advances in the realization of individual molecular‐scale devices [1,2] highlight the integration of individual devices into large‐scale functional circuits as the major challenge. DNA‐programmed assembly is a promising avenue in that direction due to the large amount of information that can be coded into the molecules and the ability to translate that information into physical constructs [3]. Large‐scale DNA‐templated electronics require, however, complex manipulation of double‐stranded DNA (dsDNA) molecules, as well as patterning of the electrical properties instilled to them by, e.g., metallization. To that end, sequence‐specific molecular lithography on single DNA molecules has been developed [4]. This was achieved by harnessing the exquisite homologous recombination process of the RecA protein. Sequence‐specific patterning of the metal coating of DNA molecules, localization of arbitrary labeled molecular objects at any desired dsDNA address without prior modifications, and generation of molecularly accurate stable dsDNA‐dsDNA junctions are demonstrated. The information encoded in the DNA molecules directs the lithographic process in analogy to the masks used in conventional microelectronics. The RecA protein provides the assembling capabilities, as well as the resist function.     

Reducing radiotoxicity in the long run

Stockpiles of spent nuclear fuel and weapons material are growing worldwide. So far, the only long-term strategy seriously considered is geological repository for several hundred thousand years. Transmutation is an option significantly reducing the time during which repositories have to be sealed, simplifying the task of protecting future generations from the radioactive remnants of our civilisation. This paper gives an overview of motives and priorities, and describes the main technique suggested for transmutation of nuclear waste.     

Synthesis and characterization of poly(N‐vinyl‐2‐pyrrolidone) grafted sodium alginate hydrogel beads for the controlled release of indomethacin

Graft copolymers of sodium alginate (NaAlg) with N‐vinyl‐2‐pyrrolidone were prepared using azobisisobutyronitrile as initiator. The graft copolymers (NaAlg‐g‐PVP) were characterized with Fourier transform infrared spectroscopy, elemental analysis, and differential scanning calorimetry. Polymeric hydrogel beads of NaAlg and NaAlg‐g‐PVP were prepared by crosslinking method using glutaraldehyde (GA) as a crosslinker in the hydrochloric acid catalyst (HCl) and these beads were used to deliver anti‐inflammatory drug, indomethacin (IM). Chemical stability of the IM after encapsulation into beads was confirmed by FTIR. Preparation conditions of the NaAlg‐g‐PVP beads were optimized by considering the percentage entrapment efficiency, particle size, swelling capacity and their release data. In vitro release studies were performed in simulated gastric fluid (pH 1.2) for the initial 2 h, followed by simulated intestinal fluid (pH 7.4) for 4 h. Effects of GA concentration, exposure time to GA, drug/polymer (d/p) ratio, and concentration of HCl on the release of IM were discussed. It was observed that IM release from the beads decreased with increasing GA concentration and exposure time. IM release also decreases with increasing d/p ratio and HCl concentration. The highest IM release was obtained to be 77% for beads crosslinked with 0.027M GA. Swelling experiments were also performed to compute molecular mass between crosslinks of the beads. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008     

Exergy losses in refrigerating systems. A study for performance comparisons in compressor and condenser

A study is carried out to describe irreversibilities in one stage refrigerating process for vapour compression cycle with refrigerant mixtures R-404A, R-410A, R-410B and R-507 as working fluids. They are calculated as exergy losses by an algorithm developed on the basis of thermodynamics. The proposed relationships have been derived from exergy balances on the system components. Emphasis is placed on parameters influencing the losses and the related results are presented through Grassmann diagrams (diagrams of exergy fluxes). Furthermore, detailed information on the variation of cycle's exergy efficiency with evaporating and condensing temperatures is given. Copyright © 2003 John Wiley & Sons, Ltd.     

Combustion of bulk density powder mixtures in a coflow of nitrogen gas: 3. The Ti-(Ti + 0.5C) layered system

Explored is the filtration combustion in Ti-(Ti + 0.5C) layered powder systems in a coflow of nitrogen gas. The presence/absence of nitrogen coflow through the layered system was found to drastically affect the character of wave propagation and structure/properties of product. The obtained data can be regarded as a basis for fabrication of new layered and composite materials in the mode of dynamic filtration combustion.      

Characterizing navigation maps for web applications with the NMM approach

This paper presents the Navigation Maps Modeling approach (NMM), which provides platform independent models for characterizing navigation maps of web applications. The NMM approach is conceived to obtain a trade off between high and low-level design notations. As high-level design notations, NMM models permit architectural details that may hinder the overall understanding of the web application to be left out. As low-level design notations, NMM models can easily be transformed into detailed architectural designs, which are very valuable at coding and maintenance stages.     

An expert decision support system for network routing: a case study

The paper presents a case study of the development of an expert decision support system which uses simple heuristic methods for fast determination of routes for simultaneous signals in a transmission network of limited capacity. It illustrates how heuristic solutions can be embodied in a model-based DSS and how the standard decision support literature, although intuitively appealing, provides little practical assistance in system construction or classification     

专家系统在化工中的应用进展

本文综述了近年来专家系统在化工领域的应用状况，并指出今后的发展趋势。     

CAL delivery selection criteria and authoring systems

Abstract  In the past, authoring systems have been used to generate computer-assisted learning materials that have often followed the rather restrictive programmed learning format. A number of innovative ways of using recently developed systems to develop CAL packages that include a wider range of learning activities (access to data bases, simulations, interactive video, etc.) are described. Analogous to the concept of a media selection model, a computer delivery mode selection model is presented as an aid to decision making for designers. This increase in flexibility should broaden the applicability of computerassisted learning (CAL) to a wider range of educational objectives and raise the level of the cognitive emphasis in learning packages, as well as facilitate the implementation of visually appealing materials. The paper also implies a standard of acceptability for authoring systems.     

Formation of geothermal resources at lithospheric subduction zones

This paper examines in a very broad fashion the formation of geothermal resources at lithospheric subduction zones. Regions of highly silicic calc-alkaline Quaternary volcanoes and/or plutons have been identified as prime candidates for having high-temperature hydrothermal systems. Regions of large tholeiitic Quaternary volcanoes have been identified as prime candidates for having large moderate-temperature hydrothermal systems. In addition, active magmatic, phreatomagnetic, and/or tectonic fracturing must be occurring in order to keep any moderate to high temperature hydrothermal system from chemically sealing. Connate, meteoric and/or oceanic water sources must also be present. Owing to tectonic and magmatic processes, volcanic arcs of subduction zones represent regions of the crust that have anomalously high mechanical and heat energy. Such arc regions are expected to contain significantly more moderate to high temperature hydrothermal systems than what is presently known. Many of these arcs are briefly discussed with respect to their potential for containing such resources.