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排序方式: 共有83条查询结果,搜索用时 15 毫秒
1.
Chang-Gun Lee Soo-Jin Lee Seokho Park Sung-E Choi Min-Woo Song Hyo Won Lee Hae Jin Kim Yup Kang Kwan Woo Lee Hwan Myung Kim Jong-Young Kwak In-Jeong Lee Ja Young Jeon 《International journal of molecular sciences》2022,23(17)
The accumulation of hepatic lipid droplets (LDs) is a hallmark of non-alcoholic fatty liver disease (NAFLD). Appropriate degradation of hepatic LDs and oxidation of complete free fatty acids (FFAs) are important for preventing the development of NAFLD. Histone deacetylase (HDAC) is involved in the impaired lipid metabolism seen in high-fat diet (HFD)-induced obese mice. Here, we evaluated the effect of MS-275, an inhibitor of HDAC1/3, on the degradation of hepatic LDs and FFA oxidation in HFD-induced NAFLD mice. To assess the dynamic degradation of hepatic LDs and FFA oxidation in fatty livers of MS-275-treated HFD C57BL/6J mice, an intravital two-photon imaging system was used and biochemical analysis was performed. The MS-275 improved hepatic metabolic alterations in HFD-induced fatty liver by increasing the dynamic degradation of hepatic LDs and the interaction between LDs and lysozyme in the fatty liver. Numerous peri-droplet mitochondria, lipolysis, and lipophagy were observed in the MS-275-treated mouse fatty liver. Biochemical analysis revealed that the lipolysis and autophagy pathways were activated in MS-275 treated mouse liver. In addition, MS-275 reduced the de novo lipogenesis, but increased the mitochondrial oxidation and the expression levels of oxidation-related genes, such as PPARa, MCAD, CPT1b, and FGF21. Taken together, these results suggest that MS-275 stimulates the degradation of hepatic LDs and mitochondrial free fatty acid oxidation, thus protecting against HFD-induced NAFLD. 相似文献
2.
MAX274/275有源滤波器的应用研究 总被引:10,自引:1,他引:10
介绍MAX274/275有源滤波器的特性及电路参数的设计和测控应用实例。 相似文献
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Eunice C. Nnaji Donald Adgidzi Michael O. Dioha Daniel R.E. Ewim Zhongjie Huan 《The Electricity Journal》2019,32(10):106672
Access to electricity is still a challenge in many parts of sub-Saharan Africa. In Nigeria, over 70% of the rural dwellers do not have access to electricity. The purpose of this paper is to examine the potential of a smart microgrid for off-grid rural electrification in Nigeria. A combination of design thinking and model-based design methodology is employed to select a suitable microgrid configuration and to develop a smart microgrid model. A system consisting of a solar photovoltaic array, battery energy storage and a diesel generator is selected, and the model is developed in Simulink. Demand data from 10 rural communities in Nigeria are used to validate the performance of the model and the potential for demand management is considered. The use of energy efficient light bulbs is found to reduce the peak electricity demand of the case study communities by 42 to 76%. Combining the proposed system with the use of LED bulbs makes the system to have 56 to 81% less net present cost than a system with a diesel generator alone and incandescent light bulbs. The proposed smart microgrid is found to be more suitable for off-grid rural electrification in Nigeria than diesel generators which are currently used for off-grid electrification in Nigeria. 相似文献
5.
简述了高真空扩散泵油275^#的生产工艺,分析了水解釜材质和精馏系统存在的问题,提出了改造意见,并比较了改造效果。结果表明,将水解釜材质由搪瓷更换成不锈钢后,既节约原材料消耗,又减少水洗过程中的物料损失和排污量,从而大幅度降低了产品的生产成本;精馏系统装置经过改造后,产品中的三甲基五苯基三硅氧烷含量比改造前生产的产品高出15个百分点,提高到84%以上;且产能翻一番。 相似文献
6.
Sylvain Lamoine Mlissa Cumenal David A. Barriere Vanessa Pereira Mathilde Fereyrolles Laëtitia Prival Julie Barbier Ludivine Boudieu Emilie Brasset Benjamin Bertin Yoan Renaud Elisabeth Miot-Noirault Marie-Ange Civiale David Balayssac Youssef Aissouni Alain Eschalier Jrme Busserolles 《International journal of molecular sciences》2022,23(1)
7.
一种高速大功率半导体脉冲激光电源的设计与仿真 总被引:2,自引:0,他引:2
主要分析了影响电容充放电类型高速大功率脉冲电源性能的主要因素 ,并运用SPICE对其特性进行仿真 ,介绍了一种基于高速大功率MOSFET管实现高速大功率半导体脉冲激光电源的方法 相似文献
8.
The absorption of CO2 from LFG in different weight concentration ammonia solution and metal salts (Zinc and Barium) is investigated in this study. Addition of metal salts results in useful metal carbonates when LFG is passed through the solution. Barium salts show a better potential of removing CO2 as compared to Zinc salts. Addition of Barium salts to ammonia solution results in a new absorbent as no study has been focused on it till date. Also metal salts are added to alkaline wastewater which not only decreases the pH of the wastewater but also useful metal carbonates are obtained from wastewater when LFG is passed through it. Different parameters like CO2 loading, reaction rate and change in pH are investigated. Formation of carbonates is proved by using SEM and XRD analysis. Raman spectroscopy was performed on the discarded liquid after removal of carbonates to understand the formation of bicarbonates, carbonates and carbamates. 相似文献
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10.
集宁供电分局使用的150 kW备用发电机为柴油发电机组,冬季低温使用时启动困难,而且启动后采用人工投入的方法,导致故障停电时间长,无法满足供电可靠性要求。为缩短故障停电时间,对150 kW备用发电机加装加热装置和自启动装置。实践证明,150 kW备用发电机加装加热装置和自启动装置后,耗油量小,启动速度快,降低了工作人员的工作量,应用效果良好。 相似文献