Synthesis of biodegradable poly(trans-4-hydroxy-N-benzyloxycarbonyl-l-proline)-block-poly(ε-caprolactone) copolymers and micellar characterizations

A series of novel types of diblock poly(trans-4-hydroxy-N-benzyloxycarbonyl-l-proline)-block-poly(ε-caprolactone) (PHpr10-b-PCL) copolymers were synthesized by ring-opening polymerization from macroinitiator poly(trans-4-hydroxy-N-benzyloxycarbonyl-l-proline) (PHpr10) and ε-caprolactone (ε-CL) in the presence of organocatalyst dl-lactic acid (dl-LA). The M_n of the copolymers increased from 3370 to 19,040 g mol⁻¹ with the molar ratio (10-100) of ε-CL to PHpr10. These products were characterized by differential scanning calorimetry (DSC), ¹H NMR, and gel permeation chromatography. According to DSC, the glass-transition temperature (T_g) of the diblock copolymers depend on the molar ratio of monomer/initiator that were added. The hydrolytic degradation behavior of PHpr-b-PCLs was evaluated from weight-loss measurements and the change of M_n and M_w/M_n. With higher PCL contents resulted in a slower weight loss, while having a higher molecular weight loss percentage. Their micellar characteristics in an aqueous phase were investigated by fluorescence spectroscopy, transmission electron microscopy (TEM), and dynamic light scattering (DLS). The block copolymers formed micelles in the aqueous phase with critical micelle concentrations (CMCs) in the range of 1.33-4.22 mg L⁻¹. The micelles exhibited a spindly shape and showed a narrow monodisperse size distribution. The obtained micelles have a relatively high drug-loading of about 26% when the feed weight ratio of amitriptyline hydrochloride (AM) to polymer was 1/1. An increase of molecular weight and hydrophobic components in copolymers produced a higher CMC value and greater loading efficiencies were observed.     

Viscoelastic effects on the scratch resistance of polymers: relationship between mechanical properties and scratch properties at various temperatures

Scratch durability of polymer surfaces and coatings is becoming critical for the increasing use of these materials in new applications, replacing other materials with harder surfaces.

Scratch resistance of polymers has been the subject of numerous studies, which have led to specific definitions for plastic deformation characterization and fracture resistance during scratch testing. Viscoelastic and viscoplastic behavior during a scratch process have been related to dynamic mechanical properties that can be measured via dynamic nano-indentation testing. Yet, the understanding of the origin of the fracture process of a polymer during scratch remains approximate. Parameters like tip shape and size, scratch velocity and loading rate, applied strain and strain rates, have been considered critical parameters for the fracture process, but no correlation has been clearly established.

The goal of this work is to define and analyze scratch parameters that relate to mechanical properties. The evolution of scratch resistance parameters as a function of temperature and strain rate, compared to the evolution of dynamic mechanical properties obtained from indentation and uniaxial tensile tests over a range of temperature for poly(methyl methacrylate) (PMMA) helped in identifying a correlation between the tensile stress–strain behavior and scratch fracture toughness.

This correlation brings a new understanding of the origin of the fracture mechanisms during a scratch process. In particular, it is demonstrated that the characteristic strain applied by the indenter is a most relevant parameter to describe the fracture resistance during a scratch process, independently of the indenter geometry.     

辽宁地区农村住宅的节能研究

针对我国辽宁地区现有农宅普遍存在的采暖能耗高而居住热环境差的问题,通过对农村住宅的体型系数、平面节能设计、围护结构等方面进行充分分析,提出适合辽宁农村住宅的保温节能措施,从而增强农宅保温隔热能力,提高室内热舒适度。力求使辽宁农村住宅在经济、技术和节能方面均达到新农村建设的要求。     

对建筑本土化表达的探索——以南京陵园小筑建筑改造为例

结合南京陵园小筑建筑改造方案的设计,在充分考虑了当地气候特点、环境特征和建筑文脉后,从总平面的规划、建筑单体设计、建筑造型和材料使用等方面,对建筑的本土化表达进行了探索和研究。同时提出一些新的见解,倡导建筑师在设计实践中对我国地域文化与建筑设计的结合进行积极的思考和运用。     

图像分割中局部能量驱动的快速主动轮廓模型

为了解决图像对象灰度分布不一致性的分割难题,提高图像分割速度,提出了一个全新的快速主动轮廓模型。它由曲线周围局部的统计信息驱动曲线发生形变演化,并使用图像中的边缘信息来引导曲线的演化方向。模型中,根据区域模板与演化曲线共同定义的局部统计信息创建数据拟合项,并应用水平集方法求解曲线的演化。对合成图像和医学图像的实验结果表明,本文提出的分割模型可以同时分割多个灰度不一致的对象,分割速度快,结果稳定,对噪声具有很好的鲁棒性。     

多荷载耦合作用下立井井壁潜在破坏区的确定

首先采用弹性理论对立井井壁进行了分析,建立了井壁破坏的理论模型,进而采用通用有限元软件ANSYS,建立了立井井壁的大型三维分离式有限元数值模型。运用这两种模型详细研究了多种荷载耦合作用对立井井壁的影响,多种荷载包括：随深度变化的土压力、随时间变化的疏水附加力以及井壁自身重量。确定了立井井壁在这三种荷载综合作用下的应力、应变集中区,论证了井壁破坏理论中疏水附加力理论的正确性,对井壁设计理论以及加固区域的确定提供了一定的理论指导。本文有限元模型的建立方法以及得到的结论,在一定程度上丰富了立井井壁理论的内容,增加了立井井壁理论研究的方法,促进了井壁附加应力说的发展。     

凝析气藏注气过程中露点压力变化特征研究

在凝析气藏循环注气和注气吞吐解除近井带反凝析堵塞的注气过程中,凝析气流体的露点压力变化较大,而在目前的凝析气藏开发过程中,对凝析气露点压力变化考虑较少.作者利用Nemeth.L.K和Kennedy.H.T.的露点压力计算经验公式,研究了向凝析气中注入N2、甲烷、CO2和丙烷等介质的过程中露点压力变化规律,并分析了衰竭式开发和注气过程中凝析气井近井带露点压力变化特征.结果表明,注甲烷使露点压力有较小幅度的减小;注入CO2和丙烷均可使凝析气露点压力有较大幅度降低;而注入N2将使露点压力升高.在凝析气藏衰竭式开发过程中,当近井带压力下降至露点压力以下时,距井筒越近,凝析气中重质组分含量越低,露点压力也越低.在注气吞吐的焖井阶段,反蒸发作用会引起凝析气中重质组分增加,露点压力将升高.     

地下洞室开挖的并行计算

介绍了有限元分析的力学理论,提出开挖释放荷载的计算方法和模拟思路。基于Krylov子空间迭代法和预条件技术,采用基于区域分解思想的粗粒度并行策略开发了地下洞室群开挖模拟的并行有限元程序。最后,用算例说明并行计算的高效性。     

黑龙江省夏季旱涝灾害区划及对策研究

采用全省81个站夏季6-8月气温、降水资料,计算变异系数;进行正态化处理,计算Z指数。确定重旱轻旱？重涝轻涝和降水、温度指标,求出发生概率结果进行灾害3级区划,即重？中？轻区划。另外进行了全省主旱区和主涝区区划,并提出了7点对策。     

微粒群优化和区域生长结合的彩色图像分割算法

提出了一种微粒群优化和区域生长相结合的彩色图像分割算法,以彩色图像直方图中自适应搜索到的峰值作为像素种子。由于搜索像素种子点是按密度进行,计算量小,大幅度提高了算法的计算速度,同时克服了传统区域生长方法不能自动选择种子且容易导致过分割的局限性。实验表明：该方法提高了图像分割速度,并可以准确地分割出目标,是一种有效的图像分割方法。