Albumin Binds Doxorubicin via Self–Assembling Dyes as Specific Polymolecular Ligands

Congo red (CR) type self–assembled ribbon–like structures (SRLS) were previously shown to interact with some proteins, including albumin. SRLS also complex with some drugs with a flat, ring–shaped structure with aromatic characteristics, intercalating them into their ribbon structure. The combination of interaction with proteins and drug binding by SRLS enables the use of such systems for immunotargeting. It is especially interesting in the case of chemotherapeutic agents. The present experiments aimed to show that the model carrier system composed of supramolecular albumin and Congo red efficiently binds doxorubicin (Dox) and that the drug can be released at reduced pH. The presented results come from the studies on such complexes differing in the molar ratio of CR to Dox. The following methods were used for the analysis: electrophoresis, dialysis, gel filtration, spectral analysis, and analysis of the size of the hydrodynamic radius using the dynamic light scattering method (DLS). The applied methods confirmed the formation of the CR–Dox complex, with large dimensions and changed properties compared with free CR. The presented results show that albumin binds both CR and its complex with Dox. Various CR–Dox molar ratios, 5:1, 2:1, and 1:1, were analyzed. The confirmation of the possibility of releasing the drug from the carriers thus formed was also obtained. The presented research is important due to the search for optimal solutions for the use of SRLS in drug immunotargeting, with particular emphasis on chemotherapeutic agents.     

In Situ Fully Light‐Driven Switching of Superhydrophobic Adhesion

An in situ fully light‐driven switching of superhydrophobic adhesion is demonstrated based on simply spin‐coating a hydrophobic azo‐polymer on an optimized micro‐nanopost arrayed silicon substrate. Furthermore, the detailed designing principles are discussed, which might shed light on efficient exploitation of superhydrophobic liquid/solid interfaces for smart microfluidic control.     

光影诗篇——墨西哥建筑艺术中的地域智慧与启迪

强烈的光照作为墨西哥一个十分突出的地域特征,对墨西哥的气候、文化乃至民众的生活习惯都产生了巨大的影响。墨西哥建筑师敏锐地捕捉到这一特征,融入自己的理解和想象,在光影与空间的交织、变化中呈现出丰富的情感色彩,使得建筑与人之间建立起直触心灵的对话。随着时代的变迁和文化的发展,建筑所要实现的功能、表达的情感在不断改变,而建筑师们对于光影的处理手段也趋于多元化,从而产生了越来越多极具特色的建筑形式。通过对墨西哥不同历史时期建筑的分析,来研究墨西哥建筑师运用光影塑造不同情感空间的多种手法和传承关系。     

Salt Concentration Effects in Planar Light‐Emitting Electrochemical Cells

Incorporation of ions in the active layer of organic semiconductor devices may lead to attractive device properties like enhanced injection and improved carrier transport. In this paper, we investigate the effect of the salt concentration on the operation of light‐emitting electrochemical cells, using experiments and numerical calculations. The current density and light emission are shown to increase linearly with increasing ion concentration over a wide range of concentrations. The increasing current is accompanied by an ion redistribution, leading to a narrowing of the recombination zone. Hence, in absence of detrimental side reactions and doping‐related luminescence quenching, the ion concentration should be as high as possible.     

关于照明设计与照明节能若干问题的探讨

本文拟就照明设计与照明节能方面的一些典型问题提出来进行分析、探讨。     

龙耀路越江隧道中智能消防疏散指示系统的应用

越江隧道为人员密集型场所,针对火灾消防逃生的需求,系统地介绍智能消防疏散指示系统。以龙耀路越江隧道为例,从系统设置、布线、工作方式和效果等角度阐述了该系统在越江隧道中的实际应用。     

门式刚架轻型房屋钢结构的荷载取值和结构计算应引起重视的问题

本文对门式刚架轻型房屋钢结构的荷载取值、结构设计和计算、优化设计中应引起重视的问题做一定的分析、探讨,供设计同行参考。     

某高档别墅地下室渗漏治理与改进措施

通过对某别墅地下室渗漏水的治理过程,说明防水设计的重要性,特别阐述了应针对具体情况设计科学合理的防水构造的理念。     

智能交通灯控制器的设计

现代社会对交通运输日趋依赖,传统的交通灯控制系统已经表现出明显的缺点：红绿灯时间相对固定,不能随车流量的改变而调整红绿灯的显示时间。基于上述原因,设计了一种简易的智能交通灯控制器系统。首先介绍了交通灯控制系统的设计方案,以单片机AT89S51芯片为中心来实现智能控制;接着用汇编语言在Keil环境下进行编程调试,通过软件Protues实现硬件仿真,最后将软件系统与硬件联调,实现了以下功能：绿灯时间可检测车流量并可通过双位数码管显示,能根据实际车流量自动设置红绿灯燃亮时间;红绿灯循环点亮,倒计时5s时黄灯闪烁警示;车辆闯红灯报警。该控制器系统在很大程度上缓解了交通压力,解决了繁华道路交通堵塞等情况。     

解决10 kV投入两相路灯出线中性点位移的方法

以某变电站的自动调谐式接地补偿装置无法正常投入运行的问题为例,分析了路灯出线投切对自动调谐式接地补偿装置运行的影响,提出了解决问题的方法。