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51.
Loris Nanni 《Pattern recognition》2006,39(4):711-713
Recently, several works have approached the HIV-1 protease specificity problem by applying a number of methods from the field of machine learning. However, it is still difficult for researchers to choose the best method due to the lack of an effective comparison. For the first time we have made an extensive study on methods for feature extraction for the problem of HIV-1 protease. We show that a fusion of classifiers trained in different feature spaces permits to obtain a drastically error reduction with respect to the performance of the state-of-the-art. 相似文献
52.
再论变化电磁场中带电超微粒子的精确量子论 总被引:1,自引:1,他引:0
利用创新的SU(1 ,1 )Lie代数理论及SO(3)Lie代数理论 ,得到变化电磁场中带电超微粒子的精确量子论 ,由此进一步明确微观领域中的时空概念 相似文献
53.
Anthraquinone [1, 2-C] methylisoxazole is synthesized from 2-ethylanthraquinone through nitration and treating with oleum. The different methods of 2-ethylanthraquinone nitrated were discussed. The optimum conditions were determined. The structure of the product was confirmed by MS and 1H NMR. 相似文献
54.
Johanna Bakker Colin F. Timberlake 《Journal of the science of food and agriculture》1985,36(12):1315-1324
The distribution of anthocyanins in methanolic skin extracts of 16 grape cultivars used for port wine production and grown at five sites in the Douro Valley in Northern Portugal has been assessed by high performance liquid chromatography. Results are confined to the seven most readily separated and identified anthocyanins and are expressed as percentages of their total (88–99% of the total integrated area). Anthocyanins based on malvidin (Mv) predominated. Of these, Mv 3-glucoside was the major pigment (33–60%), being exceeded by Mv 3-p-coumarylglucoside (2–51%) in only two cultivars; Mv 3-acetylglucoside (1–15%) was consistently the lowest. Peonidin 3-glucoside (1–27%) was prominent in four cultivars, but delphinidin 3-glucoside (1–11%), petunidin 3-glucoside (2–11%) and cyanidin 3-glucoside (trace-6%) were of low proportions throughout. The ratio Mv 3-acetylglucoside/total Mv glucosides appeared characteristic of cultivar, independent of site, and a useful aid to identification of grape cultivars. The coloured pulp of some cultivars contained peonidin 3-glucoside as a major component, present in greater proportions than in the skin; the percentage of Mv 3-p-coumarylglucoside was lower in pulp than in skin. The identities of six of the seven anthocyanins were confirmed by fast atom bombardment mass spectrometry and the structures of the Mv derivatives were determined by nuclear magnetic resonance. The formation of formyl and acetyl anthocyanin artefacts is described. 相似文献
55.
56.
FTIR spectroscopy was applied to study the initial steps of ethylene polymerization on reduced chromia-silica (0.5 wt% Cr/SiO2). To decrease the speed of the reaction small doses of gas were introduced to the catalyst in each run and C2D4 was used to confirm band assignments. At the initial steps of the reaction only ethylene molecules coordinated to probably Cr
A
2+
cations were observed. The concentration of such complexes was estimated to be about 50% of the total amount of Cr atoms in the sample. The FTIR spectrum of the polymer formed at the initial doses of C2H4 (when [C2H4] [Cr]) was found to be slightly different from that formed after excess ethylene was introduced onto the catalyst ([C2H4] > [Cr]). 相似文献
57.
近年来,基于压缩感知的无线传感器网络数据编码的研究取得了一定的进展,但大部分研究是基于"单跳"的传输模型或者没有考虑网络内节点之间的合作。本文提出了一种基于压缩感知和分簇的传感器网络数据编码方法。首先,节点根据自己的编号伪随机的产生一个M维的列向量,把感知的数据xi投影到此向量上,然后把自己的编号和投影的数据一同传输给簇头。簇头把收到的数据进行求和,并且把计算后的结果传送给下一个簇头,直到sink节点。通过仿真实验和理论分析,验证了本文提出的方法比传统的方法能更好地减少网络内数据传输量。 相似文献
58.
Hg1-xMnxTe semiconducting semimagnetic alloy has been examined in the context of its possible applications in infrared detectors.
For analysis of detector properties the intrinsic carrier concentration has been calculated as a function of temperature and
crystal composition. The starting material was In-doped Hg1-xMnxTe grown by the modified Bridgman method. The as-grown crystals with manganese content of 12-19% were p-type with carrier
concentration
and mobility of 100 cm2/ Vs at 77 K. An-type layer was formed on the surface by the annealing process in saturated Hg-vapour at 270-320° for 2 hrs. Capacitance-voltage
curves have C-3 dependence on applied voltage indicating that the junction is linearly graded. From standard electrical measurements and
spectral characteristics the main detector parameters were determined and compared to those of Hg1-xCdxTe devices. The influence of material properties on detector parameters was analyzed. In order to estimate the carrier transport
mechanisms, differential resistivities and current-voltage curves were measured over a wide range of temperaturesi.e. 25 to 300 K. From the temperature dependence of the R0A product, it was established that at high temperatures (150-300 K) the carrier transport is dominated by a recombination-generation
mechanism. In low temperature region the excess current at forward bias is probably attributed to carrier tunneling via energy
states distributed randomly within the forbidden gap. At reverse bias the leakage surface or volume currents dominate in the
carrier transport. 相似文献
59.
In response to K. Danzinger's (see record 1986-00068-001) suggestion that the first use of the term subject in the English-language psychological literature occurred in 1886 in the context of experiments involving the hypnotic state, the present author points out that there are examples of the use of the term in discussions of experiments on thought transference published by the Society for Psychical Research in the 1880's. (8 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
60.
Maria Buuales Maria Cristina Ballesteros-Briones Manuela Gonzalez-Aparicio Sandra Hervas-Stubbs Eva Martisova Uxua Mancheo Ana Ricobaraza Sara Lumbreras Cristian Smerdou Ruben Hernandez-Alcoceba 《International journal of molecular sciences》2021,22(8)
Immune checkpoint inhibitors (ICIs) have demonstrated remarkable efficacy in a growing number of malignancies. However, overcoming primary or secondary resistances is difficult due to pharmacokinetics issues and side effects associated with high systemic exposure. Local or regional expression of monoclonal antibodies (mAbs) using gene therapy vectors can alleviate this problem. In this work, we describe a high-capacity adenoviral vector (HCA-EFZP-aPDL1) equipped with a mifepristone-inducible system for the controlled expression of an anti-programmed death ligand 1 (PD-L1) blocking antibody. The vector was tested in an immune-competent mouse model of colorectal cancer based on implantation of MC38 cells. A single local administration of HCA-EFZP-aPDL1 in subcutaneous lesions led to a significant reduction in tumor growth with minimal release of the antibody in the circulation. When the vector was tested in a more stringent setting (rapidly progressing peritoneal carcinomatosis), the antitumor effect was marginal even in combination with other immune-stimulatory agents such as polyinosinic-polycytidylic acid (pI:C), blocking mAbs for T cell immunoglobulin, mucin-domain containing-3 (TIM-3) or agonistic mAbs for 4-1BB (CD137). In contrast, macrophage depletion by clodronate liposomes enhanced the efficacy of HCA-EFZP-aPDL1. These results highlight the importance of addressing macrophage-associated immunoregulatory mechanisms to overcome resistance to ICIs in the context of colorectal cancer. 相似文献