压缩机厂房桥式起重机选型浅析

从工作环境、起升高度、额定起重量、工作级别、运行速度、跨度等方面论述了桥式起重机选型的国家标准、行业标准和运行参数;从起重机行程、操作方式和导电方式论述了桥式起重机的吊装方式以及吊装操作注意事项。     

薄膜太阳能电池研究进展

薄膜太阳能电池是缓解能源危机的新型光伏器件。综述了硅基薄膜太阳能电池、CdTe薄膜太阳能电池、CIS（CIGS）薄膜太阳能电池、TiO2薄膜太阳能电池、ZnO薄膜太阳能电池和有机薄膜太阳能电池的研究现状,展望了太阳能电池的发展趋势。     

染料敏化太阳能电池的研究进展

综述了染料敏化太阳能电池的研究背景和发展过程,包括了光阳极、光敏染料和电解质的研究进展,详细阐述了该电池国内外各项关键技术的实验和产业化研究最新成果,着重分析了染料敏化太阳电池的未来发展趋势,并展望了该电池的应用前景。     

Regulation of Cell Signaling Pathways and Non-Coding RNAs by Baicalein in Different Cancers

Landmark discoveries in molecular oncology have provided a wide-angle overview of the heterogenous and therapeutically challenging nature of cancer. The power of modern ‘omics’ technologies has enabled researchers to deeply and comprehensively characterize molecular mechanisms underlying cellular functions. Interestingly, high-throughput technologies have opened new horizons for the design and scientific fool-proof evaluation of the pharmacological properties of targeted chemical compounds to tactfully control the activities of the oncogenic protein networks. Groundbreaking discoveries have galvanized the expansion of the repertoire of available pharmacopoeia to therapeutically target a myriad of deregulated oncogenic pathways. Natural product research has undergone substantial broadening, and many of the drugs which constitute the backbone of modern pharmaceuticals have been derived from the natural cornucopia. Baicalein has gradually gained attention because of its unique ability to target different oncogenic signal transduction cascades in various cancers. We have partitioned this review into different sub-sections to provide a broader snapshot of the oncogenic pathways regulated by baicalein. In this review, we summarize baicalein-mediated targeting of WNT/β-catenin, AKT/mTOR, JAK/STAT, MAPK, and NOTCH pathways. We also critically analyze how baicalein regulates non-coding RNAs (microRNAs and long non-coding RNAs) in different cancers. Finally, we conceptually interpret baicalein-mediated inhibition of primary and secondary growths in xenografted mice.     

燃料电池发电技术在电力工业中的应用及展望

介绍燃料电池发电技术的原理及特点,综述国内外各种燃料电池发电技术的发展与现状,并对我国燃料电池发电技术在电力工业中的应用进行展望。     

GPU加速的二维流体实时流动仿真

Stable Fluids是计算机图形学领域标准的流体仿真技术,但其存在一定的数值耗散.针对这一问题,将计算流体动力学领域(CFD)成熟的SMAC法移植到计算机图形学领域,结合CFD领域合理的边界条件处理及其相关技术进行二维流体的实时流动模拟.基于2种技术在可编程图形硬件(GPU)上进行Kárman漩涡以及叶轮机械叶片尾流等算例仿真,试验表明SMAC法具有更强的视觉真实感和物理真实感,是纯CFD技术的移植和加速,因而具有一定的工程价值;所采用的噪声纹理混合技术能够准确反映流体流动的物理细节,适用于计算机图形学领域,并可应用于矢量场的数据可视化.     

采用栅格理论的多机器人系统任务元管理方法

以目标为研究对象以及传统的传感器管理方法已难以满足多机器人系统中的多传感器管理研究,但如果将目标与系统任务状态结合为目标任务状态,以其对应的任务元作为研究对象会使复杂系统简单化,而基于栅格理论的管理网络也可以有效地管理不同层次不同类别的任务元.并且可以实时地监测多机器人协同工作系统任务元权重的变化情况.首先将栅格网络中每一层的目标元素对应为多机器人系统不同级别的工作任务;其次从顶层开始,逐一确定上层任务包含哪些下层任务;然后采用基于离差最大化的多属性决策方法确定任务元的权重概率,最后以一简单算例验证该管理方法的简单有效.     

Fuzzy自调整PID的Smith预估主汽温控制系统

针对火电厂锅炉主汽温系统的大滞后、大惯性、非线性等特点,设计了Fuzzy自调整PID参数的Smith预估主汽温控制系统。运用Matlab对系统在多种工况下进行了仿真,结果表明所设计的控制系统在控制品质、鲁棒性方面明显优于常规的Smith预估控制系统。     

Glioblastoma Extracellular Vesicle-Specific Peptides Inhibit EV-Induced Neuronal Cytotoxicity

WHO Grade 4 IDH-wild type astrocytoma (GBM) is the deadliest brain tumor with a poor prognosis. Meningioma (MMA) is a more common “benign” central nervous system tumor but with significant recurrence rates. There is an urgent need for brain tumor biomarkers for early diagnosis and effective treatment options. Extracellular vesicles (EVs) are tiny membrane-enclosed vesicles that play essential functions in cell-to-cell communications among tumor cells. We aimed to identify epitopes of brain tumor EVs by phage peptide libraries. EVs from GBM plasma, MMA plasma, or brain tumor cell lines were used to screen phage-displayed random peptide libraries to identify high-affinity peptides. We purified EVs from three GBM plasma pools (23 patients), one MMA pool (10 patients), and four brain tumor cell lines. We identified a total of 21 high-affinity phage peptides (12 unique) specific to brain tumor EVs. The peptides shared high sequence homologies among those selected by the same EVs. Dose–response ELISA demonstrated that phage peptides were specific to brain tumor EVs compared to controls. Peptide affinity purification identified unique brain tumor EV subpopulations. Significantly, GBM EV peptides inhibit brain tumor EV-induced complement-dependent cytotoxicity (necrosis) in neurons. We conclude that phage display technology could identify specific peptides to isolate and characterize tumor EVs.     

A Fully-Human Antibody Specifically Targeting a Membrane-Bound Fragment of CADM1 Potentiates the T Cell-Mediated Death of Human Small-Cell Lung Cancer Cells

Small-cell lung cancer (SCLC) is the most aggressive form of lung cancer and the leading cause of global cancer-related mortality. Despite the earlier identification of membrane-proximal cleavage of cell adhesion molecule 1 (CADM1) in cancers, the role of the membrane-bound fragment of CAMD1 (MF-CADM1) is yet to be clearly identified. In this study, we first isolated MF-CADM1-specific fully human single-chain variable fragments (scFvs) from the human synthetic scFv antibody library using the phage display technology. Following the selected scFv conversion to human immunoglobulin G1 (IgG1) scFv-Fc antibodies (K103.1–4), multiple characterization studies, including antibody cross-species reactivity, purity, production yield, and binding affinity, were verified. Finally, via intensive in vitro efficacy and toxicity evaluation studies, we identified K103.3 as a lead antibody that potently promotes the death of human SCLC cell lines, including NCI-H69, NCI-H146, and NCI-H187, by activated Jurkat T cells without severe endothelial toxicity. Taken together, these findings suggest that antibody-based targeting of MF-CADM1 may be an effective strategy to potentiate T cell-mediated SCLC death, and MF-CADM1 may be a novel potential therapeutic target in SCLC for antibody therapy.